Patents by Inventor John Jacob Hemperly
John Jacob Hemperly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7338778Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: October 4, 2004Date of Patent: March 4, 2008Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Patent number: 6967086Abstract: The invention provides a method and apparatus for determining the presence or absence of respiring cells, involving combining a three-dimensional biomimetic scaffold and cells onto a sensor composition.Type: GrantFiled: March 28, 2002Date of Patent: November 22, 2005Assignee: Becton Dickinson and CompanyInventors: Richard David Guarino, John Jacob Hemperly, Catherine A. Spargo, Andrea Liebmann-Vinson, Mohammad A. Heidaran
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Publication number: 20050191613Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: ApplicationFiled: October 4, 2004Publication date: September 1, 2005Inventors: J. Bruce Pitner, John Jacob Hemperly, Richard Guarino, Magdalena Wodnicka, David Stitt, Gregory Burrell, Timothy Foley, Patrick Shawn Beaty
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Patent number: 6900030Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: April 4, 2002Date of Patent: May 31, 2005Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Publication number: 20020192636Abstract: The present invention relates to cell culture. In particular, this invention is directed to methods and apparatuses used to observe or quantitate cell proliferation in the presence of potential growth promoting molecules in a two or three dimensional architecture.Type: ApplicationFiled: March 28, 2002Publication date: December 19, 2002Inventors: Richard David Guarino, John Jacob Hemperly, Catherine A. Spargo, Andrea Liebmann-Vinson, Mohammad A. Heidaran
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Publication number: 20020155424Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: ApplicationFiled: April 4, 2002Publication date: October 24, 2002Inventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Patrick Shawn Beaty
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Patent number: 6395506Abstract: The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches (diminishes) the compound's luminescent emission in a concentration dependent manner. Respiring eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed. Thus, this invention provides a convenient system to gather information on the presence, identification, quantification and cytotoxic activity of eukaryotic and/or prokaryotic cells by determining their effect on the oxygen concentration of the media in which they are present.Type: GrantFiled: June 29, 1999Date of Patent: May 28, 2002Assignee: Becton, Dickinson and CompanyInventors: J. Bruce Pitner, John Jacob Hemperly, Richard D. Guarino, Magdalena Wodnicka, David T. Stitt, Gregory J. Burrell, Timothy G. Foley, Jr., Patrick Shawn Beaty
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Patent number: 6017695Abstract: A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.Type: GrantFiled: March 26, 1993Date of Patent: January 25, 2000Assignee: Becton Dickinson and CompanyInventors: Robert Alan Reid, John Jacob Hemperly
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Patent number: 5739289Abstract: A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.Type: GrantFiled: September 17, 1996Date of Patent: April 14, 1998Assignee: Becton, Dickinson and CompanyInventors: Robert Alan Reid, John Jacob Hemperly
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Patent number: 5731154Abstract: A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules is provided. Also described are nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.Type: GrantFiled: March 21, 1995Date of Patent: March 24, 1998Assignee: Becton, Dickinson and CompanyInventors: Robert Alan Reid, John Jacob Hemperly
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Patent number: 5688916Abstract: A human brain glycoprotein homologous to the mouse F3 and the chicken contactin/F11 adhesion molecules, nucleic acid sequences encoding the human brain glycoprotein and antibodies directed against the human brain glycoprotein.Type: GrantFiled: March 21, 1995Date of Patent: November 18, 1997Assignee: Becton, Dickinson and CompanyInventors: Robert Alan Reid, John Jacob Hemperly
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Patent number: 5681931Abstract: Human restrictin proteins and nucleic acid sequences encoding them are provided. Antibodies which recognize human restrictin in human brain are disclosed. In the human brain, restrictin occurs as two major polypeptides of 180 and 160 kD located in fiber tracts. These polypeptides are similar to those seen in rat brain. Surprisingly, restrictin has also been found in the peripheral nerves of rats and humans. The antibodies also detect a 170 kD polypeptide in MATRIGEL, an extracellular matrix product of rat EHS sarcoma cells widely used as a tissue culture substrate. Monoclonal antibodies to human restrictin and assays using the human restrictin protein, antibodies and DNA sequences are also provided.Type: GrantFiled: March 15, 1995Date of Patent: October 28, 1997Assignee: Becton, Dickinson and CompanyInventors: Robert Alan Reid, Rhonda Lucille Ackley, John Jacob Hemperly
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Patent number: 5667978Abstract: The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.Type: GrantFiled: May 3, 1996Date of Patent: September 16, 1997Assignee: Becton, Dickinson and CompanyInventors: Duane David Bronson, John Jacob Hemperly
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Patent number: 5651969Abstract: The present invention provides an anti-N-CAM monoclonal antibody which enhances, rather than inhibits, neurite outgrowth both in vitro and in vivo. The antibody has positive regulatory effects on nerve cells of both the central and peripheral nervous systems, and is useful for enhancing neurite outgrowth in in vitro studies and for improving nerve regeneration and repair in vivo.Type: GrantFiled: May 3, 1996Date of Patent: July 29, 1997Assignee: Becton, Dickinson and CompanyInventors: Duane David Bronson, John Jacob Hemperly