Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

Abstract: A reaction pathfinder system can leverage historical chemical reaction data and determine a synthesis route in a reaction network. The reaction pathfinder system can account for various performance criteria of chemical reactions such as a highest yield for a molecule or a minimal number of reaction steps. A reaction pathfinder system receives a user request for a synthesis route including one of a user-specified molecule or a user-specified reaction. The reaction pathfinder system may then query a reaction network that has various synthesis routes and represents reactions of reactants to produce respective molecules. The reaction network may be composed of molecule nodes and reaction nodes. The reaction pathfinder system determines, using the reaction network, the synthesis route from the synthesis routes to fulfill the user's request.

Abstract: A sample preparation blister pack can include a plurality of reservoirs formed as blisters. The reservoirs can have an actuatable barrier layer and a seal barrier layer with contents of the reservoirs between the actuatable barrier layer and the seal barrier layer. The contents can be to facilitate isolating a biological component from a biological sample. The individual reservoirs can be adapted to release the contents through the seal barrier layer upon actuation of the actuatable barrier layer. The blister pack can have a width and a length and the reservoirs can be lined up along the length. In this example, a first reservoir contains an inert mechanical fluid and a second reservoir contains a reagent, a buffer, or a combination thereof.

Abstract: A system and method that automatically monitors product use, such as the type and amount of agricultural and/or horticultural product stored in and dispensed from a cartridge over time and/or by geographic location. Monitored data are stored in memory such as a tag on the cartridge and may be transmitted to a server for storage, aggregation, and analysis. The cartridge may be authenticated before being authorized for use for the benefit of a current user in dispensing the product. The cartridge may be refilled after confirmation of authorization codes on the cartridge and refilling equipment tags. The cartridge may be calibrated automatically based on the bulk density or other parameter of the product in the cartridge. Data may be aggregated from a plurality of cartridges automatically. As-applied data from individual cartridges may be used to verify, independent of operator input, treated area coverage and product application rate.

Abstract: A method for a first UE to perform sidelink communication with a second UE is provided. The method receives a first resource set from a cell to establish a first sidelink channel with the second UE, the first resource set indicating at least a first distance between the first and second UEs. The method establishes the first sidelink channel with the second UE based on the first resource set and transmits a set of parameters associated with the first sidelink channel to the cell. The method also sets a first timer based on at least the first distance, the first timer for determining when to establish a second sidelink channel with the second UE. When the first timer is expired and no second resource set is received from the cell, the method establishes the second sidelink channel with the second UE based on the first resource set.

Abstract: A laundry appliance including a cabinet, a wash unit tub inside the cabinet, and a drum rotatably supported within the wash unit tub. The wash unit tub includes a front tub wall having a front tub opening. The drum defines a laundry compartment therein and includes a front drum opening that provides access to the laundry compartment. A front facia is mounted to the front tub wall of the wash unit tub. A recirculation hose extends between a pump that is positioned inside the cabinet at a location below the wash unit tub and a recirculation nozzle that is mounted to the wash unit tub at a position near the top of the front tub opening. The recirculation hose passes through a window in the front facia and is routed through a gap that is disposed between the front tub wall and the front facia to the recirculation nozzle.

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to allow for the mitigation of ransomware. For example, the system can determine that an application begins to execute, determine that the application attempts to modify a file, determine a file type for the file, and create a security event if the application is not authorized to modify the file type. In another example, the system determines an entropy value between the file and the attempted modification of the file, and create a security event if the entropy value satisfies a threshold or determine a system entropy value that includes a rate at which other files on the system are being modified by the application, and create a security event if the system entropy value satisfies a threshold.

Abstract: Disclosed herein is system for providing simultaneous machine vision illumination control and human vision illumination control. The system includes a first illumination control output that is configured to provide first illumination timing information for a first illumination source. The system also includes a second illumination control output configured to provide second illumination timing information for a second illumination source. The first illumination source is configured to provide a first frequency band of illumination for machine vision. The second illumination source is configured to provide a second frequency band of illumination for human vision. The first and second frequency bands are mutually exclusive. A related system is also disclosed herein.

Abstract: In some aspects, the techniques described herein relate to a method including: aggregating data for use in an interoperable P2P application; transferring funds from a user's account associated with a first disparate P2P funding application to fund an account associated with the interoperable P2P application; transferring the funds from the account associated with the interoperable P2P application to an account associated with a second disparate P2P application; initiating a transfer of the funds from the user's account associated with a second disparate P2P application to a colleague's account associated with the second disparate P2P application; and recording transactions carried out by the interoperable P2P application in a ledger system associated with the interoperable P2P application.

Abstract: Techniques control a utility vehicle. Such techniques involve storing electric power in a lithium battery of the utility vehicle. Such techniques further involve operating a motor controller of the utility vehicle in a normal mode in which the motor controller provides electric power from a lithium battery of the utility vehicle to an electric motor of the utility vehicle to turn one or more ground engaging members of the utility vehicle. Such techniques further involve, after operating the motor controller in the normal operating mode, operating the motor controller in a walkaway mode in which the motor controller configures the electric motor to provide braking torque.

Abstract: One embodiment provides a method, the method including: capturing, utilizing at least one image capture device coupled to an information handling device, video image data of a user; identifying, utilizing a gesture detection system and within the video image data, a location of hands of the user in relation to a gesture zone; and performing, utilizing the gesture detection system and based upon the location of the hands of the user in relation to the gesture zone, an action, wherein the producing the framed video stream comprises performing an action based upon the location of the hands of the user in relation to the gesture zone. Other aspects are claimed and described.

Abstract: Systems and techniques are described for robust radar-based gesture-recognition. A radar system detects radar-based gestures on behalf of application subscribers. A state machine transitions between multiple states based on inertial sensor data. A no-gating state enables the radar system to output radar-based gestures to application subscribers. The state machine also includes a soft-gating state that prevents the radar system from outputting the radar-based gestures to the application subscribers. A hard-gating state prevents the radar system from detecting radar-based gestures altogether. The techniques and systems enable the radar system to determine when not to perform gesture-recognition, enabling user equipment to automatically reconfigure the radar system to meet user demand. By so doing, the techniques conserve power, improve accuracy, or reduce latency relative to many common techniques and systems for radar-based gesture-recognition.

Abstract: An implement for use with an excavator includes a lightweight housing, a first coupling feature, a ground penetrating radar antenna, a controller, a wireless communication circuit and a rotation unit. The lightweight housing has an upper surface, a lower surface and a cavity. The first coupling feature is located on the upper surface and cooperates with a second coupling feature on an excavator arm. The ground penetrating radar antenna is mounted near the lower surface. The controller is mounted within the cavity and provides outgoing signals to the radar antenna, receives incoming signals from the radar antenna and interprets the incoming signals so as to provide implement output information. The wireless communication circuit is mounted within the cavity and transmits the implement output information. The rotation unit is mounted within the cavity and rotates the housing vis-à-vis the excavator arm.

Abstract: The techniques described herein relate to methods and apparatus for firearm safety mechanisms, visual safety indicators, and related techniques. A firearm includes a handle comprising one or more buttons disposed at least partially within a surface of the handle, such that the one or more buttons can be in contact with an operator's hand when the operator grasps the handle; a safety mechanism in mechanical communication with the trigger. The safety mechanism comprises: a first position that blocks actuation of the trigger; and a second position that does not block actuation of the trigger; and at least one processor configured to: upon determining an input code matches a stored code, transmits a signal to the safety mechanism to change the safety mechanism from the first position to the second position so that the firearm can be fired by the operator.

Abstract: The techniques described herein relate to methods and apparatus for firearm safety mechanisms, visual safety indicators, and related techniques. A firearm includes a handle comprising one or more buttons disposed at least partially within a surface of the handle, such that the one or more buttons can be in contact with an operator's hand when the operator grasps the handle; a safety mechanism in mechanical communication with the trigger. The safety mechanism comprises: a first position that blocks actuation of the trigger; and a second position that does not block actuation of the trigger; and at least one processor configured to: upon determining an input code matches a stored code, transmits a signal to the safety mechanism to change the safety mechanism from the first position to the second position so that the firearm can be fired by the operator.

Abstract: An electronic key may include a partial capacitor comprising a capacitive metal plate in communication with a processor. The capacitive metal plate of the partial capacitor is configured to form a capacitor with a corresponding capacitive metal plate of a lock when brought into proximity with the metal plate of the lock. Data may be transferred from the key to the lock using a capacitor formed by combining the two metal plates, wherein a common ground is established between the metal plate of the key and the metal plate of the lock through a parasitic capacitance present between the key and lock circuitry. Audit trail data may be recorded based on usage of the key.

Abstract: Various examples described herein are directed to systems and methods for providing a user interface at a plurality of computing devices. A first interface application executing at a first computing device may determine a first state for a user interface. The first interface application may detect a set of user computing devices for providing the user interface to a user and select a second computing device that is in the set of user computing devices based at least in part on the first state of the user interface. The first interface application may send a description of the user interface to the second computing device.

Abstract: Systems and methods are provided that use a trained process to reply to a request comprising query data defining a query and context data defining contextual factors for the query from a device. The query is answered by one or more selected APIs of a plurality of APIs that invoke respective services to prepare a response. The trained process determines an execution plan responsive to the query data and the context data and is configured using training to define execution plans comprising selected APIs where a particular API is selected for the plan if it answers at least a portion of the query and the selected APIs together prepare the response optimized for the device according to the context data. The plan is provided to an execution component to execute the plan using the selected APIs and send the response to the requesting device.

Abstract: Access points can be mounted in a variety of locations or orientations and can support multiple communications protocols. In some embodiments, an access point includes a main housing and a front housing. The main and front housing are connected by a hinge. A Wi-Fi antenna is included in the front housing in some embodiments. The access point is configured for use in either an open or closed position. When mounted in a vertical position, the front housing can be lowered into a horizontal position, which facilitates a preferred orientation of an antenna with respect to the ground. A first set of cooling fins serves to maintain components of the access point offset from a wall to which the access point is mounted. This facilitates airflow. Additional fins act as a spacer between the main housing and the front housing when the access point is used in a closed position. This facilitates air flow around both sides of the main housing.

Abstract: Methods, systems, and apparatus for receiving, by a voice action system, data specifying trigger terms that trigger an application to perform a voice action and a context that specifies a status of the application when the voice action can be triggered. The voice action system receives data defining a discoverability example for the voice action that comprises one or more of the trigger terms that trigger the application to perform the voice action when a status of the application satisfies the specified context. The voice action system receives a request for discoverability examples for the application from a user device having the application installed, and provides the data defining the discoverability examples to the user device in response to the request. The user device is configured to provide a notification of the one or more of the trigger terms when a status of the application satisfies the specified context.