Patents by Inventor John Jonas V. Duncia

John Jonas V. Duncia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiotensin II receptor blocking imidazoles
    Patent number: 5354867
    Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: October 11, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Substituted pyrazole angiotensin II antagonists
    Patent number: 5315013
    Abstract: Substituted pyrazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: May 24, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Gregory J. Wells
  • Fused aryl substituted imidazole angiotensin II receptor inhibitors
    Patent number: 5254546
    Abstract: Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: October 19, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert J. Ardecky, David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
    Patent number: 5210079
    Abstract: Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxy methyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imi dazole and pharmaceutically acceptable salts thereof are useful for treating chronic renal failure, mediated by angiotensin-II.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: May 11, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Pancras C. Wong
  • Substituted 1,2,3 triazole angiotensin II antagonists
    Patent number: 5189048
    Abstract: This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as a treatment for congestive heart failure in mammals. The heterocyclic compounds of the invention have the structural formula (I) ##STR1## or pharmaceutically suitable salts thereof.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: February 23, 1993
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Greogry J. Wells
  • Substituted 1,2,3-triazole angiotensin II antagonists
    Patent number: 5081127
    Abstract: Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: January 14, 1992
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Gregory J. Wells
  • Angiotensin II receptor blocking benzimidazoles
    Patent number: 4880804
    Abstract: Substituted benzimidazoles such as ##STR1## and pharmaceutically suitable salts thereof are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: November 14, 1989
    Assignee: E. I. Du Pont De Nemours and Company
    Inventors: David J. Carini, John Jonas V. Duncia, Sung-Eun Yoo
  • Tetrazole intermediates to antihypertensive compounds
    Patent number: 4874867
    Abstract: Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U.S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: ##STR1## wherein X.sup.1 and X.sup.2 are as described in the specification.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: October 17, 1989
    Assignee: E. I. Du Pont De Nemours and Company
    Inventors: Paul E. Aldrich, John Jonas V. Duncia, Michael E. Pierce
  • Tetrazole intermediates to antihypertensive compounds
    Patent number: 4820843
    Abstract: Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U.S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: ##STR1## wherein X.sup.1 and X.sup.2 are as described in the specification.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: April 11, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Paul E. Aldrich, John Jonas V. Duncia, Michael E. Pierce