Abstract: This invention relates to methods and systems for reliable ultra-high purity (UHP) helium gas supply and maintaining dedicated onsite inventory. Specifically, the invention employs multiple ISO containers whereby vaporized UHP helium in the standby ISO container(s) is used to build-up pressure in the online ISO container. The thermal shields of the ISO containers can be used to decrease heat leaks into the backup ISO container thereby decreasing helium vaporation rate and the amount of gas needed to be withdrawn in order to maintain the maximum allowable working pressure (MAWP) of the vessel. An even lower supply rate is possible by drawing UHP helium gas using an economizer valve but maintaining liquid in the ISO container. This makes it possible to efficiently manage the supply rate, from low flows to higher flow requirements, and to optimize UHP helium draw rate from the storage vessels.

Abstract: A method for managing or treating an inflammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount effective to protect mucosal surfaces of the proximal digestive tract from erosion or ulceration induced by the NSAID.