Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A surgical stringer includes a pair of bases, each of the pair of bases having a flat bottom surface, a pivot coupling the pair of bases together, the pair of bases being rotatable with respect to one another, and a pair of poles, each of the pair of poles being coupled to a one of the pair of bases and extending orthogonally thereto, the distance between the pair of poles being variable.

Abstract: A surgical stringer includes a pair of bases, each of the pair of bases having a flat bottom surface, a pivot coupling the pair of bases together, the pair of bases being rotatable with respect to one another, and a pair of poles, each of the pair of poles being coupled to a one of the pair of bases and extending orthogonally thereto, the distance between the pair of poles being variable.

Abstract: There is disclosed an integrated system for converting content provided by an operator of multiple cable television systems (e.g. a MSO) to content suitable for distribution within a multi-dwelling unit (MDU). A chassis is provided comprising slots for receiving cableCARDs, an input for receiving a cable feed, and an output for transmitting the RF signal. Circuitry within the chassis is configured to extract selected encrypted programs from the cable feed, forward these encrypted programs to the cableCARDs for decryption, and encrypt the decrypted programs using an encryptor such as a Pro:Idiom™ encryptor. A control unit is provided for controlling the operation of at least some of the circuitry within the chassis. The control unit is responsive to instructions sent over a network cable to allow for remote control of the circuitry.

Abstract: A multi-channel encoder, demodulator, modulator and transmission system for digital video insertion in network edge applications includes a circuit comprising slots for receiving a plurality of plug-in demodulator and encoder cards, a transmission stream multiplexer in communication with the slots, a QAM modulator in communication with the transmission stream modulator, a optical transmission section in communication with the QAM modulator, and a monitor and control system for monitoring and controlling the circuit. The system also includes a power supply for powering the circuit, and a lockable cabinet for enclosing the circuit, the plug-in demodulator and encoder cards, and the power supply, the lockable cabinet enclosing space for a cable modem connectable to the circuit.

Abstract: There is disclosed an integrated system for converting content provided by an operator of multiple cable television systems (e.g. a MSO) to content suitable for distribution within a multi-dwelling unit (MDU). A chassis is provided comprising slots for receiving cableCARDs, an input for receiving a cable feed, and an output for transmitting the RF signal. Circuitry within the chassis is configured to extract selected encrypted programs from the cable feed, forward these encrypted programs to the cableCARDs for decryption, and encrypt the decrypted programs using an encryptor such as a Pro:Idiom™ encryptor. A control unit is provided for controlling the operation of at least some of the circuitry within the chassis. The control unit is responsive to instructions sent over a network cable to allow for remote control of the circuitry.

Abstract: In order to determine the nature of fluid passing through a pipe, for example whether material being pumped through a pipe is sludge or liquid phase, high frequency ultrasonic pulses from a generator are caused to propagate around a peripheral wall of the pipe to produce ringing in the pipe, and the characteristics of the ringing are measured and compared in a controller with stored data to determine the nature of the fluid content of the pipe. A sludge pump may be controlled according to whether the data obtained shows that the material passing through the pipe is sludge or liquid tunnelling through the sludge.