Abstract: This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by anti-body-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.

Abstract: Provided herein are methods of treating neuroendocrine prostate cancer (NEPC) with immune cells comprising a CEA-CAM5 chimeric antigen receptor (CAR). Also provided are methods of reducing or eliminating NEPC cancer cells with immune cells comprising a CEACAM5 CAR. Also provided are methods of treating a cancer with a molecular signature that is similar to a molecular signature of NEPC (e.g., small cell lung cancer (SCLC), small cell carcinoma of the pancreas (SCCP), or small cell prostate cancer).

Abstract: Disclosed are various embodiments for providing networked applications that are segmented into multiple client-cached executable modules. Multiple networked applications are provided by an application server, and a module cache is maintained in a client. The client obtains a user invocation of a particular functionality associated with a networked application. One of the modules associated with the particular functionality is obtained by the client from the application server over a network in response to determining that the module is not already in the module cache. The module is executed by the client to provide the particular functionality. A data cache may be implemented that includes data blocks that have been used, are being used, or are predicted to be used by the networked application.

Abstract: The present invention provides at least an electronic system for network conference. The electronic system includes a user right module for storing and maintaining a plurality of user rights associated to each user of the electronic system, and a meeting right module for creating a meeting having a plurality of meeting rights according to associated user rights of a meeting creator. A participant right module is presented for determining a plurality of participant rights according to the plurality of meeting rights of the meeting and the associated user rights of a participant of the meeting. The system includes a plurality of participant client modules for receiving and sending media stream according to the plurality of participant rights of corresponding participant, and a matrix module for processing and distributing media stream to and from the plurality of participant client modules according to the plurality of participant rights.

Abstract: Methods for fabricating contacts of semiconductor device structures include forming a dielectric layer over a semiconductor substrate with active-device regions spaced at a first pitch, forming a first plurality of substantially in-line apertures over every second active-device region of the active-device regions, and forming a second plurality of substantially in-line apertures laterally offset from apertures of the first plurality over active-device regions over which apertures of the first plurality are not located. Methods for designing semiconductor device structures include forming at least two laterally offset sets of contacts over a substrate including active-device regions at a first pitch, the contacts being formed at a second pitch that is about twice the first pitch.

Abstract: Methods for fabricating contacts of semiconductor device structures include forming a dielectric layer over a semiconductor substrate with active-device regions spaced at a first pitch, forming a first plurality of substantially in-line apertures over every second active-device region of the active-device regions, and forming a second plurality of substantially in-line apertures laterally offset from apertures of the first plurality over active-device regions over which apertures of the first plurality are not located. Methods for designing semiconductor device structures include forming at least two laterally offset sets of contacts over a substrate including active-device regions at a first pitch, the contacts being formed at a second pitch that is about twice the first pitch.

Abstract: Apparatus and method for packet redundancy and recovery are disclosed. In a transmitter, parity packets are generated by executing exclusive OR between the corresponding data packets, and are transmitted along with the data packets to a receiver. In the receiver, lost data packets are found out and are recovered by executing exclusive OR between the corresponding data packets and the corresponding parity packets. This invention enhances the reliability of streaming data transmission using loss-recovery packets. Data packets are grouped and transmitted with redundant packets to allow the receiver to recover a lost packet within the group. This will minimize the need and therefore the time and delay to request a retransmission of the damaged or lost packets.

Abstract: A semiconductor device structure includes staggered contacts to facilitate small pitches between active-device regions and conductive lines while minimizing one or both of misalignment during fabrication of the contacts and contact resistance between sections of the contacts. The contacts of one row communicate with every other active-device region and are staggered relative to the contacts of another row, which communicate with the remaining active-device regions. Each contact may include a relatively large contact plug with a relatively large upper surface to provide a relatively large amount of tolerance as a contact hole for an upper portion of the contact that is formed. The contact holes may be formed substantially simultaneously with trenches for conductive traces, such as bit lines, in a dual damascene process. Intermediate structures are also disclosed, as are methods for designing semiconductor device structures.

Abstract: An apparatus and method for stabilizing a threshold voltage in an active matrix field emission device are disclosed. The method includes formation of radiation-blocking elements between a cathodoluminescent display screen of an FED and semiconductor junctions formed on a baseplate of the FED.

Abstract: The present invention provides at least an electronic system for network conference. The electronic system includes a user right module for storing and maintaining a plurality of user rights associated to each user of the electronic system, and a meeting right module for creating a meeting having a plurality of meeting rights according to associated user rights of a meeting creator. A participant right module is presented for determining a plurality of participant rights according to the plurality of meeting rights of the meeting and the associated user rights of a participant of the meeting. The system includes a plurality of participant client modules for receiving and sending media stream according to the plurality of participant rights of corresponding participant, and a matrix module for processing and distributing media stream to and from the plurality of participant client modules according to the plurality of participant rights.

Abstract: Apparatus and method for packet redundancy and recovery are disclosed. In a transmitter, parity packets are generated by executing exclusive OR between the corresponding data packets, and are transmitted along with the data packets to a receiver. In the receiver, lost data packets are found out and are recovered by executing exclusive OR between the corresponding data packets and the corresponding parity packets. This invention enhances the reliability of streaming data transmission using loss-recovery packets. Data packets are grouped and transmitted with redundant packets to allow the receiver to recover a lost packet within the group. This will minimize the need and therefore the time and delay to request a retransmission of the damaged or lost packets.

Abstract: A system for sharing display information comprising a network apparatus for connecting to a receiver of display information, and a memory for storing at least one program, a first graphics driver, a second graphics driver, and a network sharing program. A processor configured to execute the program, the first graphics driver, and the second graphics driver stored in the memory. The program is executed for generating display information to the first graphics driver. The first graphics driver is executed for forwarding display information to the second graphics driver and the network sharing program. The network sharing program is executed for processing display information and for sending the processed display information to the receiver through the network apparatus. The second graphics driver is executed for translating display information. The system also includes a graphics apparatus for generating display information of a whole desktop according to display information sent from the second graphics driver.

Abstract: A semiconductor device structure includes staggered contacts to facilitate small pitches between active-device regions and conductive lines while minimizing one or both of misalignment during fabrication of the contacts and contact resistance between sections of the contacts. The contacts of one row communicate with every other active-device region and are staggered relative to the contacts of another row, which communicate with the remaining active-device regions. Each contact may include a relatively large contact plug with a relatively large upper surface to provide a relatively large amount of tolerance as a contact hole for an upper portion of the contact is formed. The contact holes may be formed substantially simultaneously with trenches for conductive traces, such as bit lines, in a dual damascene process. Intermediate structures are also disclosed, as are methods for designing semiconductor device structures.

Abstract: An active matrix display that does not require a transistor or similar current switching device at each pixel. Instead, the display employs in each pixel a temperature-controlled current source that provides to the field emitters of the pixel an amount of electrical current which varies in response to the temperature of a temperature sensor. Each pixel further includes a thermoelectric heat transfer circuit which transfers heat to or from the sensor in an amount which varies in response to the video signal. Consequently, the video signal controls the temperature of the sensor within a pixel's temperature-controlled current source, which controls the current flow through the pixel's field emitters.

Abstract: An apparatus for stabilizing the threshold voltage in an active matrix field emission device is disclosed. The apparatus includes the formation of radiation-blocking elements between a cathodoluminescent display screen of the FED and semiconductor junctions formed on a baseplate of the FED.

Abstract: A layer of polyimide or polysilicon is used as a mask in vapor hydrogen fluoride etching. Both non-photosensitive and photosensitive type polyimide may be used. A non-photosensitive polyimide mask requires the use of photoresist for patterning with a lithographic mask. Alternatively, photosensitive type polyimide may be patterned directly with the use of a lithographic mask. The resulting polyimide mask enables the etching of very small features with great uniformity. Such etching may be used to expose micropoint emitters of field emission devices.

Abstract: An apparatus and a method for stabilizing the threshold voltage in an active matrix field emission device are disclosed. The method includes the formation of radiation-blocking elements between a cathodoluminescent display screen of the FED and semiconductor junctions formed on a baseplate of the FED.

Abstract: An apparatus for stabilizing the threshold voltage in an active matrix field emission device is disclosed. The apparatus includes the formation of radiation-blocking elements between a cathodoluminescent display screen of the FED and semiconductor junctions formed on a baseplate of the FED.

Abstract: An apparatus and a method for stabilizing the threshold voltage in an active matrix field emission device. The method includes the formation of radiation-blocking elements between a cathodoluminescent display screen of the FED and semiconductor junctions formed on a baseplate of the FED.

Abstract: An apparatus and a method for stabilizing the threshold voltage in an active matrix field emission device. The method includes the formation of radiation-blocking elements between a cathodoluminescent display screen of the FED and semiconductor junctions formed on a baseplate of the FED.