Patents by Inventor John K. Walker
John K. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240116857Abstract: In one aspect, the present disclosure provides compounds such as those with one or more quaternary ammonium ions joined by one or more aromatic rings. These compounds may have a formula: These compounds may be used in the treatment of a microbial infection such as a bacterial infection including infections of drug resistant strains of bacteria.Type: ApplicationFiled: July 6, 2023Publication date: April 11, 2024Applicants: Saint Louis University, The Board of Regents of the University of OklahomaInventors: John K. WALKER, Valentin V. RYBENKOV, Ramakumar KINTHADA, Hang ZHAO, Elena I. ZGURSKAYA, Terri BOEHM, Zoya PETRUSHENKO
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Publication number: 20240002380Abstract: Disclosed are compounds that regulate REV-ERB nuclear receptors that would be useful for treatment of various diseases. These compounds may be used in therapeutic applications such as in the treatment of neurodegenerative disease such as anxiety disorder, autoimmune diseases or disorders, or muscular disorders such as sarcopenia.Type: ApplicationFiled: April 13, 2023Publication date: January 4, 2024Applicants: Saint Louis University, Pelagos Pharmaceuticals, Inc.Inventors: John K. Walker, Thomas Patrick Burris, Sadichha Sitaula, Arindam Chatterjee, Napoleon Clement D'Cunha, Eric Jon Jacobsen, James Robert Blinn
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Patent number: 11795162Abstract: In one aspect, the present disclosure describes new estrogen receptor-related orphan receptor (EER) inverse agonist compounds. Also described are pharmaceutical formulations, methods of synthesis and uses thereof.Type: GrantFiled: August 17, 2018Date of Patent: October 24, 2023Assignee: Saint Louis UniversityInventors: Thomas Burris, John K. Walker, Carissa S. Hampton, Keith McCormick Haynes, Kristine Griffett, Cyrielle Billon, Sadichha Sitaula
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Patent number: 11746097Abstract: In some aspects, the present disclosure provides compounds of the formula: (I) or (II) wherein the variables are as defined herein. In some embodiments, these compounds may be used to treat cancer or other hyperproliferative diseases, as well as atherosclerosis and coronary artery disease.Type: GrantFiled: June 23, 2017Date of Patent: September 5, 2023Assignee: Saint Louis UniversityInventors: Thomas Burris, John K. Walker, Colin Flaveny, Arindam Chatterjee
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Publication number: 20220267312Abstract: Provided herein are compounds of the formula: wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as an infection of an antibiotic resistant bacteria.Type: ApplicationFiled: January 19, 2022Publication date: August 25, 2022Applicants: Saint Louis University, United States Government as Represented by the Department of Veterans AffairsInventors: John K. WALKER, Feng CAO, Terri BOEHM, Kinthada RAMAKUMAR
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Patent number: 11092549Abstract: Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.Type: GrantFiled: May 22, 2019Date of Patent: August 17, 2021Assignees: Saint Louis University, The Board of Regents of the University of OklahomaInventors: John K. Walker, Keith Haynes, Narges Abdali, Valentin V. Rybenkov, Helen I. Zgurskaya
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Publication number: 20200308135Abstract: In some aspects, the present disclosure provides compounds of the formula: (I) or (II) wherein the variables are as defined herein. In some embodiments, these compounds may be used to treat cancer or other hyperproliferative diseases, as well as atherosclerosis and coronary artery disease.Type: ApplicationFiled: June 23, 2017Publication date: October 1, 2020Applicant: Saint Louis UniversityInventors: Thomas BURRIS, John K. WALKER, Colin FLAVENY, Arindam CHATTERJEE
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Publication number: 20200247792Abstract: In one aspect, the present disclosure describes new estrogen receptor-related orphan receptor (EER) inverse agonist compounds. Also described are pharmaceutical formulations, methods of synthesis and uses thereof.Type: ApplicationFiled: August 17, 2018Publication date: August 6, 2020Applicant: Saint Louis UniversityInventors: Thomas BURRIS, John K. WALKER, Carissa S. HAMPTON, Keith McCormick HAYNES, Kristine GRIFFETT, Cyrielle BILLON, Sadichha SITAULA
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Publication number: 20200018705Abstract: Described are compounds and methods useful in measuring membrane permeability and efflux transporter activity in bacteria, including multidrug resistance Gram negative bacteria.Type: ApplicationFiled: May 22, 2019Publication date: January 16, 2020Inventors: John K. WALKER, Keith HAYNES, Narges ABDALI, Valentin V. RYBENKOV, Helen I. ZGURSKAYA
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Patent number: 9050334Abstract: The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.Type: GrantFiled: July 15, 2011Date of Patent: June 9, 2015Assignee: INNOV88 LLCInventors: Anderson Gaweco, John K. Walker, Joseph B. Monahan, Jerry W. Cubbage, Jeffery Carroll
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Publication number: 20120035150Abstract: The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.Type: ApplicationFiled: July 15, 2011Publication date: February 9, 2012Inventors: Anderson Gaweco, John K. Walker, Joseph B. Monahan, Jerry W. Cubbage, Jeffery Carroll
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Patent number: 7902195Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.Type: GrantFiled: April 20, 2007Date of Patent: March 8, 2011Assignee: Pharmacia & Upjohn Company LLCInventors: Robert O Hughes, Andrew Simon Bell, David Graham Brown, Dafydd Owen, Michael John Palmer, Christopher Phillips, David L. Brown, Yvette M. Fobian, John N. Freskos, Steven E. Heasley, E. Jon Jacobsen, Todd Maddux, Brent Mischke, John M. Molyneaux, Joseph B. Moon, D. Joseph Rogier, Jr., Michael B. Tollefson, John K. Walker
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Publication number: 20100234435Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.Type: ApplicationFiled: May 13, 2010Publication date: September 16, 2010Inventors: Samit K. Bhattacharya, Matthew F. Brown, Peter H. Dorff, Susan D. LaGreca, John W. Mickelson, Joseph A. Cornicelli, David L. Brown, Jennings Rex, John K. Walker, Rita Huff, Joseph W. Strohbach, Robert J. Maguire
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Publication number: 20090227641Abstract: The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.Type: ApplicationFiled: November 7, 2008Publication date: September 10, 2009Inventors: Samit K. Bhattacharya, Matthew F. Brown, Peter H. Dorff, Susan D. LaGreca, John W. Mickelson, Joseph A. Cornicelli, David L. Brown, Rex Jennings, John K. Walker, Rita Huff, Joseph W. Strohbach, Robert J. Maguire
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Patent number: 7057049Abstract: This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R3A, R3B, R3C, Y1, Y2, Y3, Y4, and Y5 are as defined in the specification.Type: GrantFiled: April 1, 2003Date of Patent: June 6, 2006Assignee: Pharmacia CorporationInventors: Kimberley C. Allen, Dennis K. Anderson, John E. Baldus, Todd Boehlow, Jerry D. Clark, Dan R. Dukesherer, Albert D. Edney, Tom Fevig, Sastry Kunda, Jon P. Lawson, Patrick H. Lau, Lisa L. McDermott, Michael K. Mao, Jodi L. Moe, Partha Mudipalli, Win Naing, Shaun R. Selness, Christine B. Seymour, Tobin C. Schilke, Shekhar Viswanath, John K. Walker, Gopichand Yalamanchili
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Patent number: 6897318Abstract: This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R3A, R3B, R3C, Y1, Y2, Y3, Y4, and Y5 are as defined in the specification.Type: GrantFiled: September 25, 2002Date of Patent: May 24, 2005Assignee: Pharmacia CorporationInventors: Kimberly K. Allen, Dennis K. Anderson, John E. Baldus, Jerry D. Clark, Albert D. Edeny, Patrick H. Lau, Daniel R. Dukesherer, Lisa McDermott, Michael K. Mao, Gopi Yalamanchili, Jodi L. Moe, Partha Mudipalli, Win Naing, Shaun R. Selness, Christine Seymour, Shekhar Viswanath, John K. Walker
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Publication number: 20040082551Abstract: This invention is directed generally to pyrazoles that, inter alia, inhibit p38 kinase, TNF, and/or cyclooxygenase-2 activity.Type: ApplicationFiled: June 5, 2003Publication date: April 29, 2004Inventors: Alan G. Benson, Thomas P. Fraher, Michael E. Hepperle, Kevin D. Jerome, Win Naing, Shaun R. Selness, John K. Walker
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Publication number: 20030225108Abstract: This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers.Type: ApplicationFiled: April 1, 2003Publication date: December 4, 2003Inventors: Kimberley C. Allen, Dennis K. Anderson, John E. Baldus, Todd Boehlow, Jerry D. Clark, Daniel R. Dukesherer, Albert D. Edney, Tom Fevig, Sastry Kundra, Jon P. Lawson, Patrick H. Lau, Lisa L. McDermott, Michael K. Mao, Jodi L. Moe, Partha Mudipalli, Win Naing, Shaun R. Selness, Christine B. Seymour, Tobin C. Schilke, Shekhar Viswanath, John K. Walker, Gopichand Yalamanchili
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Publication number: 20030144302Abstract: This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers.Type: ApplicationFiled: September 25, 2002Publication date: July 31, 2003Inventors: Kimberly K. Allen, Dennis K. Anderson, John E. Baldus, Jerry D. Clark, Albert D. Edeny, Patrick H. Lau, Dan R. Dukesherer, Lisa McDermott, Michael K. Mao, Gopi Yalamanchili, Jodi L. Moe, Partha Mudipalli, Win Naing, Shaun R. Selness, Christine Seymour, Shekhar Viswanath, John K. Walker
