Patents by Inventor John Karanicolas

John Karanicolas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODULATION OF ANTIBODY ACTIVITY
    Publication number: 20220175918
    Abstract: Compositions and methods for modulating antibody activity are disclosed.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 9, 2022
    Inventors: John Karanicolas, Jittasak Khowsathit, Daniel Pushparaju Yeggoni
  • Structure-based design of peptide inhibitors of amyloid fibrillation
    Patent number: 8754034
    Abstract: The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 17, 2014
    Assignees: The Regents of the University of California, University of Washington
    Inventors: David S. Eisenberg, Stuart A. Sievers, John Karanicolas, David Baker
  • STRUCTURE-BASED DESIGN OF PEPTIDE INHIBITORS OF AMYLOID FIBRILLATION
    Publication number: 20100204085
    Abstract: The invention provides methods for designing peptides that inhibit aggregation in target polypeptides. The candidate inhibitory peptidic compounds have an oligomeric sequence that forms energetically-favorable interactions with the amino acid sequence of the steric zipper region of the target protein, and also possess a zipper-disrupting feature that disrupt the peptide stacking at the steric zipper region. This method can be used to obtain inhibitory peptides to disrupt fibril formation involving any protein for which a steric zipper sequence can be identified. The invention also provides inhibitory peptidic compounds, which can be used in pharmaceutical compositions and methods for treating polypeptide aggregation-associated diseases or conditions.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 12, 2010
    Inventors: David S. Eisenberg, Stuart A. Sievers, John Karanicolas, David Baker