Patents by Inventor John Kasianowicz

John Kasianowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of stabilization of functional nanoscale pores for device applications
    Publication number: 20050191616
    Abstract: A membrane is disclosed made from a compound having a hydrophilic head group, an aliphatic tail group, and a polymerizable functional group. The membrane spans an aperture and may be polymerized. The membrane may be useful for DNA sequencing when the membrane includes an ion channel.
    Type: Application
    Filed: February 28, 2005
    Publication date: September 1, 2005
    Inventors: Devanand Shenoy, Alok Singh, William Barger, John Kasianowicz
  • Designed protein pores as components for biosensors
    Publication number: 20050131211
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: September 21, 2004
    Publication date: June 16, 2005
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • Designed protein pores as components for biosensors
    Patent number: 6824659
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: November 30, 2004
    Assignee: University of Massachusetts
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • DESIGNED PROTEIN PORES AS COMPONENTS FOR BIOSENSORS
    Publication number: 20040191845
    Abstract: A mutant staphylococcal alpha hemolysin polypeptide containing a heterologous analyte-binding amino acid which assembles into an analyte-responsive heptameric pore assembly in the presence of a wild type staphylococcal alpha hemolysin polypeptide, digital biosensors, and methods of detecting, identifying, and quantifying analytes are described.
    Type: Application
    Filed: February 15, 2001
    Publication date: September 30, 2004
    Applicant: United States of America, as Represented by the Secrectary of Commerce
    Inventors: Hagan Bayley, Orit Braha, John Kasianowicz, Eric Gouaux
  • Characterization of individual polymer molecules based on monomer-interface interactions
    Patent number: 6015714
    Abstract: A method for sequencing a nucleic acid polymer by (1) providing two separate, adjacent pools of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage from one pool to the other pool of only one nucleic acid polymer at a time; (2) placing the nucleic acid polymer to be sequenced in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the nucleic acid polymer passes through the channel so as to sequence the nucleic acid polymer.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: January 18, 2000
    Assignees: The United States of America as represented by the Secretary of Commerce, The Regents of the University of California
    Inventors: Richard Baldarelli, Daniel Branton, George Church, David W. Deamer, Mark Akeson, John Kasianowicz
  • Characterization of individual polymer molecules based on monomer-interface interactions
    Patent number: 5795782
    Abstract: A method is disclosed for characterizing a linear polymer molecule by measuring physical changes across an interface between two pools of media as the linear polymer traverses the interface and monomers of the polymer interact with the interface, where the physical changes are suitable to identify characteristics of the polymer.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: August 18, 1998
    Assignees: President & Fellows of Harvard College, The Regents of the University of California
    Inventors: George Church, David W. Deamer, Daniel Branton, Richard Baldarelli, John Kasianowicz