Patents by Inventor John KASTELEIN

John KASTELEIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250228852
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Application
    Filed: December 4, 2024
    Publication date: July 17, 2025
    Applicant: NewAmsterdam Pharma B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Patent number: 12186315
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: January 7, 2025
    Assignee: NewAmsterdam Pharma B.V.
    Inventors: John Ford, Patrick Round, John Kastelein, Atsuhiro Kawaguchi, Koichi Tomiyasu, Kozo Oka
  • Publication number: 20240024315
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Application
    Filed: April 3, 2023
    Publication date: January 25, 2024
    Applicant: NewAmsterdam Pharma B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Patent number: 11642344
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: May 9, 2023
    Assignee: NewAmsterdam Pharma B.V.
    Inventors: John Ford, Patrick Round, John Kastelein, Atsuhiro Kawaguchi, Koichi Tomiyasu, Kozo Oka
  • Publication number: 20230041138
    Abstract: The present invention relates to the treatment of cardiovascular disease, more particularly to the treatment of subjects suffering from or at risk of suffering from atherosclerotic cardiovascular disease that are hypo-responsive to HIS treatment. The present inventors have found that HIS hypo-responders show remarkable improvements in their blood lipid profiles when their statin therapy is combined with treatment with the CETP inhibitor obicetrapib. In a general aspect, the present invention thus provides methods of treating subjects that are hypo-responsive to high intensity statin (HIS) therapy, said method comprising the administration of a composition comprising obicetrapib or a pharmaceutically acceptable salt, hydrate or solvate thereof.
    Type: Application
    Filed: July 25, 2022
    Publication date: February 9, 2023
    Inventors: John KASTELEIN, Marc DITMARSCH, Michael DAVIDSON
  • Publication number: 20210228580
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Patent number: 11013742
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: May 25, 2021
    Assignee: DEZIMA PHARMA B.V.
    Inventors: John Ford, Patrick Round, John Kastelein, Atsuhiro Kawaguchi, Koichi Tomiyasu, Kozo Oka
  • Publication number: 20200230138
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said CETP inhibitor.
    Type: Application
    Filed: April 9, 2020
    Publication date: July 23, 2020
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA
  • Patent number: 10653692
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: May 19, 2020
    Assignee: DEZIMA PHARMA BV
    Inventors: John Ford, Patrick Round, John Kastelein, Atsuhiro Kawaguchi, Koichi Tomiyasu, Kozo Oka
  • Patent number: 10300059
    Abstract: The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (CETP) inhibitor and a HMG CoA Reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: May 28, 2019
    Assignee: DEZIMA PHARMA B.V.
    Inventors: John Ford, Patrick Round, John Kastelein
  • Publication number: 20180000818
    Abstract: The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (CETP) inhibitor and a HMG CoA Reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
    Type: Application
    Filed: August 3, 2015
    Publication date: January 4, 2018
    Applicant: DEZIMA PHARMA B.V.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN
  • Publication number: 20170182048
    Abstract: The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 29, 2017
    Applicant: AMGEN INC.
    Inventors: John FORD, Patrick ROUND, John KASTELEIN, Atsuhiro KAWAGUCHI, Koichi TOMIYASU, Kozo OKA