Patents by Inventor John Kehoe

John Kehoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8536113
    Abstract: Short oligopeptides are provided which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: September 17, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Mohit Trikha, Wang Bryan, Frank Shi, John Kehoe
  • Patent number: 8394378
    Abstract: The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: March 12, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: John Kehoe, Jennifer Lee Gardiner, Tatiana Ort, Kristen Picha, Mary Ryan, John Wheeler
  • Publication number: 20120108795
    Abstract: The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.
    Type: Application
    Filed: September 26, 2011
    Publication date: May 3, 2012
    Inventors: John Kehoe, Jennifer Lee Gardiner, Tatiana Ort, Kristen Picha, Mary Ryan, John Wheeler
  • Publication number: 20110230406
    Abstract: We have disclosed affinity peptides toward BMP-2. More specifically we have disclosed an affinity biomatrix where the affinity peptide is covalently attached to a biocompatible, biodegradable polymer. The affinity biomatrix is useful in preparing controlled release devices for BMP-2.
    Type: Application
    Filed: March 10, 2011
    Publication date: September 22, 2011
    Applicant: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: John Kehoe, Daphne A. Salick, Carrie H. Fang, Chunlin Yang, Abla Creasey
  • Patent number: 7868152
    Abstract: The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: January 11, 2011
    Assignee: Los Alamos National Security, LLC
    Inventors: Carolyn R. Bertozzi, John Kehoe, Andrew M. Bradbury
  • Publication number: 20100151003
    Abstract: Short oligopeptides are provided which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 17, 2010
    Inventors: Mohit Trikha, Wang Bryan, Frank Shi, John Kehoe
  • Publication number: 20100009441
    Abstract: The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin.
    Type: Application
    Filed: September 15, 2009
    Publication date: January 14, 2010
    Applicant: LOS ALAMOS NATIONAL LABORATORY
    Inventors: Carolyn R. Bertozzi, John Kehoe, Andrew M. Bradbury
  • Patent number: 7589182
    Abstract: The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: September 15, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Carolyn R. Bertozzi, John Kehoe, Andrew M. Bradbury