Abstract: Techniques are described that allow an implantable device to sense activity data from a patient and estimate the patient's amount of energy expended based on the sensed data. The implantable device may alternatively determine an amount of time the patient has been active based on the activity data. For example, the implantable device may be an implantable gastric stimulator. A system may provide feedback to the patient, a family member, or a doctor about the patient's activity or energy expenditure. The data may be provided in table or graphical format, and may show daily or weekly energy data or may show a trend of the daily or weekly energy data.

Abstract: Techniques are described that allow an implantable device to sense gastric data and activity data from a patient, and estimate the patient's amount of energy consumed and energy expended based on the sensed data. A system provides feedback to the patient, a family member, or a doctor about the patient's energy consumed, energy expended, and net energy. The data may be provided in table or graphical format, and may show daily or weekly energy balance data or may show a trend of the daily or weekly energy data. The patient may receive feedback by an implanted alert module that provides and audio alert or a vibration alert. In addition, data acquired by the system may be used to adjust the patient's stimulation therapy parameters.

Abstract: The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.

Abstract: The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.

Abstract: A large surface electrode optimized for use as a subcutaneous defibrillation electrode. The electrode includes an insulative electrode pad carrying a large surface electrode. Both the upper and lower surfaces of the electrode pad are covered by a fabric mesh to reduce fluid build-up at the site of implantation. The defibrillation electrode is spaced at least 0.5" from the external periphery of the pad.