Abstract: Sensors and systems for determining a physiological parameter such as blood pressure using external pressure are disclosed. Such sensors and/or systems may be embodied in a wearable user device. The wearable user device may include a cuff configured to apply a pressure to a portion of a user at one or more substantially constant pressure levels; a photoacoustic sensor configured to obtain photoacoustic signals generated from light incident on a blood vessel; and a wearable structure including the cuff and the photoacoustic sensor. Techniques involving the wearable user device may include: obtaining photoacoustic signals from a portion of the user; determining a curve associated with the user, the curve including a plurality of spatial measurements of the blood vessel as a function of a plurality of discrete pressures, the curve enabling determination of a characteristic of the blood vessel; and determining the physiological parameter based at least on the characteristic.

Abstract: A computing system and method can be used to implement a version of federated learning (FL) that incorporates adaptivity (e.g., leverages an adaptive learning rate). In particular, the present disclosure provides a general optimization framework in which (1) clients perform multiple epochs of training using a client optimizer to minimize loss on their local data and (2) a server system updates its global model by applying a gradient-based server optimizer to the average of the clients' model updates. This framework can seamlessly incorporate adaptivity by using adaptive optimizers as client and/or server optimizers. Building upon this general framework, the present disclosure also provides example specific adaptive optimization techniques for FL which use per-coordinate methods as server optimizers. By focusing on adaptive server optimization, the use of adaptive learning rates is enabled without increase in client storage or communication costs and compatibility with cross-device FL can be ensured.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: A system for cooling plungers which operate in high pressure pumps. The system uses a plunger having a blind bore formed therein. The blind bore may receive a number of different objects, some of which are fixed to the plunger. A heat exchanger may be installed within the blind bore. The heat exchanger may have internal passages or openings which allow for the circulation of fluid within the blind bore, thus cooling the plunger. The heat exchanger may be formed of a material having a higher thermal conductivity than the material used to form the plunger. This allows the heat exchanger to cool the plunger more effectively than if the plunger were solid or filled with an empty air space. The heat exchanger may be sealed within the bore of the plunger, or exposed.

Abstract: A manifold assembly configured for use with a fluid end used in oil and gas operations. The manifold assembly comprises upper and lower manifolds supported on side posts such that the manifolds and posts define a central opening. In operation, the fluid end is positioned within the central opening such that the manifold assembly surrounds the fluid end. The manifold assembly is not attached to the fluid end other than flexible conduits interconnecting the fluid and the manifolds. The manifold assembly is modular and when assembled, may be moved together as a single unit.

Abstract: A high pressure pump. The pump comprises a fluid end assembly supported on a power end assembly. The power end assembly is modular and held together by a first set of stay rods. The fluid end assembly comprises a plurality of fluid end sections positioned in a side-by-side relationship. Each fluid end section comprises a housing made of multiple-piece construction. One or more pieces of the housing are configured to having a second set of stay rods attached thereto. The second set of stay rods interconnect the fluid end assembly and a power end assembly and a vertically offset from the first set of stay rods.

Abstract: An aspect of the present disclosure is directed to a connector. The connector is suited to connectorizing exactly two conductors. The connector includes a forward connector body, a rear connector body, a metal frame and exactly two electrical contacts. The rear connector body interfaces with the forward connector body. Further, the metal frame, which includes a shielding interface, surrounds at least a portion of both the forward and rear connector bodies. The electrical contacts extend from the rear connector body into the forward connector body. A first of the electrical contacts is electrically coupled to a first conductor of a shielded cable and the second of the electrical contacts is electrically coupled to a second conductor of the shielded cable. The shield interface of the metal frame is electrically coupled to the shield of the shielded cable.

Abstract: Embodiments of secondary batteries having electrode assemblies are provided. A secondary battery can comprise an electrode assembly having a stacked series of layers, the stacked series of layers having an offset between electrode and counter-electrode layers in a unit cell member of the stacked series. A set of constraints can be provided with a primary constraint system with first and second primary growth constraints separated from each other in a longitudinal direction, and connected by at least one primary connecting member, and a secondary constraint system comprises first and second secondary growth constraints separated in a second direction and connected by members of the stacked series of layers. The primary constraint system may at least partially restrain growth of the electrode assembly in the longitudinal direction, and the secondary constraint system may at least partially restrain growth in the second direction that is orthogonal to the longitudinal direction.

Abstract: An apparatus for generating a highly energetic plasma employs a low-energy neutral beam injected into a magnetically contained mirror plasma to produce plasma ions boosted in energy to fusion levels by a coordinated radiofrequency field.

Abstract: A fluid end assembly made of a plurality of fluid end sections positioned in a side-by-side relationship. Each fluid end section comprises a plurality of individual components joined together in a row. Two sets of fasteners are used to secure various components of each fluid end section together. When the fluid end section is assembled, a first set of fasteners is in a spaced relationship with and faces a second set of fasteners. At least one component making up the multi-piece fluid end section is configured to have a plurality of stay rods attached thereto. The stay rods interconnect the fluid end assembly and a power end assembly.

Abstract: Multi-sensor devices and systems are disclosed. A multi-sensor user device may include a first acoustic sensor and a second acoustic sensor disposed at a first distance from each other, the first and second acoustic sensors each configured to obtain respective first and second acoustic signals associated with a blood vessel of a user; a first motion sensor and a second motion sensor disposed at a second distance from each other, the first and second motion sensors each configured to obtain respective first and second motion signals associated with the blood vessel; a photoacoustic sensor configured to obtain a photoacoustic signal generated from light incident on the blood vessel; and a wearable structure securable to the user and comprising the first acoustic sensor, the second acoustic sensor, the first motion sensor, the second motion sensor, and the photoacoustic sensor.

Abstract: Some disclosed examples involve directing two or more pulse groups of light towards a target object during a total light transmission time interval, each pulse group time interval within the total light transmission time interval being separated from a successive pulse group time interval by an off time interval. The target object may be part of a human body or an animal body. In some examples, no light is transmitted towards the target object during the off time interval. Some disclosed examples involve receiving acoustic signals corresponding to photoacoustic (PA) responses of a target object to the two or more pulse groups and determining one or more heart rate waveforms of the human or animal body based on the acoustic signals.

Abstract: Some disclosed examples pertain to an apparatus that can include a platen, a light source system, a receiver system, and an electromagnetic interference (EMI) shield. The light source system can include light source system circuitry, a light-emitting component, and a light guide component having a substantially uniform cross-section. The light-emitting component provides light to an area of the platen via the light guide component. The receiver system can include at least two receiver stack portions residing proximate on either side of the light guide component. The receiver system detects acoustic waves corresponding to a photoacoustic response of a target object proximate the area of the platen, to light emitted by the light source system. The EMI shield shields the receiver system from at least some of the EMI produced by the light source system circuitry. The light guide component conveys light through a portion of the EMI shield.

Abstract: Multi-sensor devices and systems are disclosed. A multi-sensor user device may include a first acoustic sensor and a second acoustic sensor disposed at a first distance from each other, the first and second acoustic sensors each configured to obtain respective first and second acoustic signals associated with a blood vessel of a user; a first motion sensor and a second motion sensor disposed at a second distance from each other, the first and second motion sensors each configured to obtain respective first and second motion signals associated with the blood vessel; at least one optical sensor configured to obtain reflected optical signals from the blood vessel; and a wearable structure securable to the user and comprising the first acoustic sensor, the second acoustic sensor, the first motion sensor, the second motion sensor, and the at least one optical sensor.

Abstract: An induction welding coil includes a spine having a planar body with opposing ends, and a pair of prongs extending perpendicularly from the opposing ends of the spine. Each of the prongs has a planar body, wherein the spine and the pair of prongs are formed from a ferrite material to define a ferrite core. The induction welding coil further includes a coil wire having a plurality of winding that surround the planar body of the spine.

Abstract: A process for packaging a product including the steps of providing a cleaning wipe that includes nonwoven strips and moving the cleaning wipe in a direction aligned with the longitudinal axis of the cleaning wipe. A gas is moved from positions on opposite sides of the longitudinal axis and beyond the longitudinal edges of the cleaning wipe to bend the free ends of the nonwoven strips out of plane relative to the fixed ends of the strips.

Abstract: An apparatus and associated method may include a light source system that includes a light-emitting component, and a receiver system configured to detect an acoustic wave that corresponds to a photoacoustic response of a blood vessel to light emitted by the light source system. A control system may be configured to determine a wave characteristic from the acoustic wave and to estimate a tensive state classification based on the determined wave characteristic. The tensive state classification may be one of a plurality of tensive state classifications that each include different ranges of diastolic and systolic values.

Abstract: Synchronized sensors and systems are disclosed. Techniques involving a synchronized sensor system for determining a physiological parameter of a user may include: obtaining one or more first measurements at a first location of the user via a first sensor; obtaining one or more second measurements at a second location of the user via a second sensor; and determining the physiological parameter of the user based on the one or more first measurements, the one or more second measurements, and a distance between the first location and the second location, the distance between the first location and the second location determined based on acoustic communication between the first sensor and the second sensor. In some implementations, acoustic communication may include ultrasound signals between the first sensor and the second sensor, which may be time synchronized by exchanging timestamps.

Abstract: An apparatus may include a platen, a light source system, an ultrasonic receiver system and a control system, the light source system being configured for providing first light and second light having first and second wavelengths to a target object on an outer surface of the platen and including one or more light guides configured to convey light parallel to a surface of the platen. The control system may be configured to: cause the light source system to provide the first light and the second light to the target object at a first time and a second time, respectively; receive first and second ultrasonic receiver signals from the ultrasonic receiver system corresponding to photoacoustic responses of the target object to the first light and the second light, respectively; and estimate one or more blood vessel features based on at least one of the first or the second ultrasonic receiver signals.

Abstract: Some disclosed examples involve obtaining, via a sensor system of a wearable device, first heart rate waveforms at a first wearable device configuration corresponding with a first position at least a portion of the sensor system. Some examples involve prompting, via a user interface of the wearable device, a user to change the wearable device configuration to a second wearable device configuration, the second wearable device configuration corresponding with a second position of one or more sensors of the sensor system. Some examples involve obtaining second heart rate waveforms at the second wearable device configuration and determining, based at least in part on the first heart rate waveforms and the second heart rate waveforms, whether to change a wearable device configuration or maintain a current wearable device configuration. Some examples involve prompting the user either to change the wearable device configuration or maintain the current wearable device configuration.