Abstract: The use of substituted amides for modulating the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11?HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

Abstract: The present invention relates to a curing assembly comprising at least two light sources combined into one light path, wherein the light sources are capable of curing a material exposed to the combined light path. The invention also relates to a method of curing a material or material in contact with a heat sensitive material comprising providing a curable material or a material associated with a heat sensitive material and exposing curable material to a combined light path from the curing assembly.

Abstract: The use of substituted amides for modulating the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11?HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.

Abstract: A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11?-hydroxysteroid dehydrogenase type 1 (11?HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.

Abstract: A display sheet comprises in order a substrate, transparent first conductors, a light-modulating material having different first and second field-changeable stable optical states, a light-absorbing layer that absorbs a portion of the visible spectrum and transmits a portion of the visible spectrum, substantially reflective second conductors forming conductive segments that operate in conjunction with the light-absorbing layer to provide reflective light additional to that provided by the light-modulating material, and substantially reflective non-conductive material, disposed over one or more background areas of light-absorbing layer not covered by second conductors, to provide reflective light additional to that provided by the light-modulating material such that the total reflected light in background areas more closely match the total reflected light in the segmented areas when both areas are in the same optical state

Abstract: A shelf talker for displaying short and longer term information includes a backplane including a plurality of electrical conductors; a plurality of single character display chips mounted on the backplane in electrical contact with the electrical conductors for displaying the short term information; and a graphic overlay located over the backplane bearing the longer term information and defining apertures for displaying the short term information displayed by the single character display chips.