Abstract: An example system for treatment of a vessel lesion, the system comprising a catheter shaft; a balloon having an exterior surface, where the balloon is configured to move between a deflated condition and an inflated condition; and a sheathed scoring element that is separate from the balloon and includes: a scoring member having a proximal end region, a distal end region, and a body portion therebetween; and a sheath including a channel, where the sheath is configured to move relative to the scoring member between: a delivery condition where at least a portion of the scoring member is located in the channel; and a scoring condition where the portion of the scoring member is located distal to a distal end of the channel and is configured to contact a target site.

Abstract: A side branch stent includes a main body portion, an extension portion extending from the main body portion circumferentially around less than a full circumference of the main body portion, and an eyelet extending from the main body portion. A stent system includes a main branch stent and a side branch stent configured to engage a side wall of the main branch stent such that the main branch stent supports a main branch and the side branch stent supports a side branch. A method includes positioning first and second guidewires in side and main branches of a body lumen, advancing the side branch stent over the first guidewire into the side branch while the second guidewire is positioned through the eyelet and extends into the main branch distal of the bifurcation, and deploying the side branch stent in the side branch with the extension portion extending into the body lumen.

Abstract: A perfusion catheter for drug delivery to tissue, the perfusion catheter comprising: an elongate catheter shaft having a proximal end region and a distal end region and including an inflation lumen extending between the proximal end region and the distal end region; a balloon positioned adjacent to the distal end region of the elongate catheter shaft and in fluid communication with the inflation lumen, the balloon being configured to move between an collapsed configuration and an expanded configuration where a first region of a surface of the balloon defines a perfusion channel; and a therapeutic coating disposed on a second region of the surface of the balloon, wherein the second region is configured to contact the tissue in the expanded configuration.

Abstract: Drug delivery systems for delivering a therapeutic agent to a lumen while allowing for fluid perfusion. An illustrative drug delivery system may comprise an inner elongate shaft extending from a proximal end to a distal end and including a lumen extending from the proximal end to the distal end thereof and an outer elongate shaft extending from a proximal end to a distal end and including a lumen extending from the proximal end to the distal end thereof. The outer elongate shaft may be disposed over and axially movable relative to the inner elongate shaft. A self-expanding drug delivery device may include a plurality of longitudinally extending struts and may be movable between a radially collapsed configuration and a radially expanded configuration. A drug coating may be disposed on at least a portion of a radially outward surface of the longitudinally extending struts.

Abstract: An ostial stent delivery device may include a first elongate shaft including a first lumen and extending along a central longitudinal axis, wherein the first elongate shaft includes a first inflatable balloon fixedly attached proximate a distal end of the first elongate shaft; and a second elongate shaft including a second lumen, the first elongate shaft being at least partially disposed within the second lumen. The second elongate shaft includes a second inflatable balloon fixedly attached proximate a distal end of the second elongate shaft. The second inflatable balloon is disposed at least partially proximal of the first inflatable balloon. The first inflatable balloon has a substantially cylindrical shape along a majority of its length in the deployed configuration. The second inflatable balloon has a substantially biconical shape having a central axis oriented parallel to the central longitudinal axis in the deployed configuration.

Abstract: A replacement heart valve system may include a delivery sheath and a replacement heart valve. The replacement heart valve may include a mesh anchor member disposed within the delivery sheath in an elongated delivery configuration, the mesh anchor member being expandable to a deployed configuration when unconstrained by the delivery sheath. The mesh anchor member may include an upstream chamber, a downstream chamber, and a tubular middle portion extending between the upstream chamber and the downstream chamber. The replacement heart valve may include a diaphragm disposed within the downstream chamber of the mesh anchor member, wherein the diaphragm is configured to selectively prevent fluid flow through the replacement heart valve.

Abstract: The present disclosure, in its various aspects, is directed to instrument accessory devices, implementation methods, and related delivery systems. Embodiments according to the present disclosure, including as described herein, may increase the effectiveness and efficiency of colonoscopy procedures, such as the removal of polyps. In one example, an embodiment includes an instrument accessory device with an expandable member, the device configured to receive an instrument through an instrument lumen, wherein the inner surface of the expandable member comprises a material characterized by a first elasticity and the outer surface of the expandable member comprises a material characterized by a second elasticity, the second elasticity being more elastic than the first elasticity.

Abstract: An injection catheter system that includes (a) an actuator; (b) an outer needle comprising a sharp tip and a tubular body defining a lumen, and extending distally from the actuator; and (c) an inner needle at least partially disposed within the lumen and extending distally from the actuator, the inner needle having a distal tip configured such that at least a portion of the distal tip has a surface contour with an interstitial cavity adapted to receive a therapeutic gel. The system is configured such that (a) in a first position, the distal tip is fully disposed within the lumen to temporarily retain the therapeutic gel in the interstitial cavity and (b) in a second position, the outer needle is retracted proximally, exposing the interstitial cavity to deliver the therapeutic gel to a target area in a body.

Abstract: A replacement heart valve system may include a delivery sheath and a replacement heart valve. The replacement heart valve may include a mesh anchor member disposed within the delivery sheath in an elongated delivery configuration, the mesh anchor member being expandable to a deployed configuration when unconstrained by the delivery sheath. The mesh anchor member may include an upstream chamber, a downstream chamber, and a tubular middle portion extending between the upstream chamber and the downstream chamber. The replacement heart valve may include a diaphragm disposed within the downstream chamber of the mesh anchor member, wherein the diaphragm is configured to selectively prevent fluid flow through the replacement heart valve.

Abstract: An injection catheter system that includes (a) an actuator; (b) an outer needle comprising a sharp tip and a tubular body defining a lumen, and extending distally from the actuator; and (c) an inner needle at least partially disposed within the lumen and extending distally from the actuator, the inner needle having a distal tip configured such that at least a portion of the distal tip has a surface contour with an interstitial cavity adapted to receive a therapeutic gel. The system is configured such that (a) in a first position, the distal tip is fully disposed within the lumen to temporarily retain the therapeutic gel in the interstitial cavity and (b) in a second position, the outer needle is retracted proximally, exposing the interstitial cavity to deliver the therapeutic gel to a target area in a body.

Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating.

Abstract: In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating.