Patents by Inventor John Kincaid

John Kincaid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Publication number: 20110092476
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: October 18, 2010
    Publication date: April 21, 2011
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20110065681
    Abstract: Compounds are provided according to formula 1: where A, B, W, X?, L, R1, R3, R4b, and m? are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 17, 2011
    Inventors: Zhi-Liang Wei, Sumithra Gowlugari, Carl Kaub, Zhan Wang, Yeyu Cao, John Kincaid
  • PYRID-2YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20110009432
    Abstract: Fused heterocyclic compounds are provided according to formula 1a or 1b: where R1, R2, and R3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Application
    Filed: March 31, 2008
    Publication date: January 13, 2011
    Inventors: Zhi-Liang Wei, John Kincaid, Michael G. Kelly, Donogh John Roger O'Mahony, Carl Kaub
  • Fused heterocyclic compounds, and compositions and uses thereof
    Publication number: 20100317676
    Abstract: Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4?, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Application
    Filed: March 1, 2010
    Publication date: December 16, 2010
    Inventors: Michael G. Kelly, John Kincaid, Carl J. Kaub
  • Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20100298285
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 25, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20100292235
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: November 18, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl compounds as P2Xmodulators and uses thereof
    Patent number: 7816371
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 19, 2010
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, legal representative, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
    Publication number: 20100184802
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: July 22, 2010
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • 2-Substituted and 4-substituted aryl nitrone compounds
    Publication number: 20100168112
    Abstract: The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.
    Type: Application
    Filed: July 15, 2009
    Publication date: July 1, 2010
    Inventors: Michael G. KELLY, John Kincaid, Satyanarayana Janagani
  • Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
    Patent number: 7745451
    Abstract: Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4?, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 29, 2010
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Carl J. Kaub
  • NOVEL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF
    Publication number: 20100022531
    Abstract: Compounds are disclosed that have a formula represented by the following (1), the compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: September 1, 2006
    Publication date: January 28, 2010
    Applicant: RENOVIS, INC.
    Inventors: John Kincaid, Yeyu Cao, Carl Kaub, David Lonergan, Michael G. Kelly
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20100004222
    Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 22, 2007
    Publication date: January 7, 2010
    Applicant: Renovis, Inc.
    Inventors: Michael G. Kelly, Carl J. Kaub, John Kincaid, Satyanarayana Janagani, Guoxian Wu, Zhi-Liang Wei, Kiran Sahasrabudhe, Matthew Duncton, Ravindra B. Upasani, Yunfeng Fang, Matthew Cox, Jianhua He
  • Heterocyclic compounds and their use as anticancer agents
    Publication number: 20090318438
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: September 25, 2008
    Publication date: December 24, 2009
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid
  • Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
    Publication number: 20090298825
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 16, 2007
    Publication date: December 3, 2009
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7576099
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: August 18, 2009
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, Jianhua He, legal representative, Zhi-Liang Wei, Carl Kaub, YunFeng Fang
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Publication number: 20090170838
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: July 16, 2008
    Publication date: July 2, 2009
    Inventors: Michael G. Kelly, John Kincaid
  • HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS
    Publication number: 20090048301
    Abstract: The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
    Type: Application
    Filed: July 9, 2004
    Publication date: February 19, 2009
    Applicant: IMCLONE SYSTEMS INCORPORATED
    Inventors: Xiaoling Chen, Hai-Ying He, Joel Kawakami, Alexander Kiselyov, Xiaohu Ouyang, Vatee Pattaropong, Evgueni Piatnitski, Maria Carolina Tuma, John Kincaid
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20080300243
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 24, 2006
    Publication date: December 4, 2008
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, YunFeng Fang, Zhi-Liang Wei, Carl Kaub, Jianhua He
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Publication number: 20080287415
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 20, 2008
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • 2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
    Publication number: 20080275037
    Abstract: Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Application
    Filed: March 31, 2008
    Publication date: November 6, 2008
    Inventors: Zhi-Liang Wei, Donogh John Roger O'Mahony, Matthew Duncton, John Kincaid, Michael G. Kelly, Zhan Wang