Abstract: In its various aspects and embodiments, the invention comprises a method for treating vitiligo in a patient comprising administering a composition comprising an effective amount of at least one Janus kinase inhibitor and phototherapy.

Abstract: A method of modifying a CAD system model performed on a data processing system includes receiving a dataset of co-ordinates representing an article in 2d, or in 3d and receiving 2d or 3d constraints respectively, to be applied to any changes to the dataset of co-ordinates for the article. A modification to be applied to the dataset is received and combined with the relevant 2d and 3d constraints to produce a constrained modification for each of the article and associated article. The constrained modification is solved in 2d and in 3d to determine whether a solution exists in which all constraints are met. If the solve is successful, the constrained modification is applied to each dataset simultaneously and, updated datasets are stored. If the solve fails, the constraints may be reduced and the solve step repeated, or the process is terminated.

Abstract: A mask system and an air delivery conduit for use in the treatment of respiratory disorders. The air delivery conduit may comprise a textile having an airtight arrangement. A support structure may be provided to the conduit to provide form.

Abstract: A method for annealing an absorber layer is disclosed, the method including contacting a surface of the absorber layer with an annealing material provided as a gel. The annealing material comprises cadmium chloride and a thickening agent. A viscosity of the gel of the annealing material is greater than or equal to 5 millipascal seconds.

Abstract: A display system comprising a steerable display having a monocular field of view of at least 1 degree, positioned within a scannable field of view of at least 20 degrees, the steerable display positioned for a user. In one embodiment, the steerable display is positioned for the user's fovea.

Abstract: Systems, methods, and computer-readable media are disclosed for an enhanced valet mode for vehicles. An example method may include receiving a request for a temporary valet passcode. The example method may also include generating a temporary valet passcode. The example method may also include displaying a request for entry of the temporary valet passcode. The example method may also include determining that an input has been received. The example method may also include determining that a mobile device is located within the vehicle or within a threshold distance from the vehicle. The example method may also include preventing the vehicle from starting based on authorization of the mobile device for a period of time subsequent to the input being received.

Abstract: Described herein are systems, devices, methods, and media for connecting a user for providing emergency response assistance to victims and emergency service providers. In some embodiments, a method for automatically populating an incident report includes the steps of: generating a victim code for display at a first electronic device; receiving an emergency data request comprising the victim code from a second electronic device associated with an emergency service provider (ESP) personnel; gathering emergency data associated with the victim code; transmitting the emergency data associated with the victim code to the second electronic device associated with the ESP personnel; and automatically populating, at the second electronic device associated with the ESP personnel, one or more fields of an incident report using the emergency data associated with the victim code.

Abstract: Examples of assessing susceptibility of a target pathogen based on autofluorescence, are described. In an example, a sample containing a target pathogen and a predefined concentration of a target drug may be obtained. Thereafter, autofluorescence features based on autofluorescence exhibited by the sample in response to the sample being subjected to excitation radiation, may be determined. Once the autofluorescence features are determined, they may be analyzed based on a susceptibility-detection model to determine susceptibility of the target pathogen with respect to the target drug. In an example, the susceptibility-detection model is trained based on a training autofluorescence features correlated with reference data, in which the reference data includes information pertaining to susceptibility or resistance of a reference pathogen with respect to a reference drug.

Abstract: Techniques are for detecting presence of a problematic cellular entity in a target. In an example, using an analysis model, a fluorescence-based image is analyzed. The analysis model is trained using a number of reference fluorescence-based images for detecting the presence of problematic cellular entities in targets. Based on the analysis, a problematic cellular entity present in the target is detected. To perform the detection, the analysis model is trained to differentiate between the fluorescence in the fluorescence-based image emerging from the problematic cellular entity and the fluorescence in the fluorescence-based image emerging from regions other than the problematic cellular entity.

Abstract: Techniques are for detecting presence of a problematic cellular entity in a target. In an example, using an analysis model, a fluorescence-based image is analyzed. The analysis model is trained using a number of reference fluorescence-based images for detecting the presence of problematic cellular entities in targets. Based on the analysis, a problematic cellular entity present in the target is detected. To perform the detection, the analysis model is trained to differentiate between the fluorescence in the fluorescence-based image emerging from the problematic cellular entity and the fluorescence in the fluorescence-based image emerging from regions other than the problematic cellular entity.

Abstract: A power unit with manual override control for a hydraulic system having an initial state and at least one operational state is provided, comprising: a tank for storing hydraulic fluid that moves between a first chamber and a second chamber of a hydraulic cylinder; a pump that routes the hydraulic fluid in and out of the tank; a first relief valve; a first solenoid valve configured to shift between a plurality of positions based on the at least one operational state of the hydraulic system; a first check valve connected to the first solenoid valve; a manual override control unit comprising: a second check valve; and a second solenoid valve configured to shift between a plurality of positions based on activation of a manual override control, wherein the activation of the manual override control returns the hydraulic system from the at least one operational state to the initial state.

Abstract: A system and method for performing a desired verb action involves administering units of memory having a set of non-mutable components in a knowledge base. The components are organized as a graph with nodes and edges extending between the nodes. The nodes correspond to the components and are representative of definitional knowledge and procedural knowledge of a model. The model has a component representative of a vocabulary of components including components representative of performable actions and components a performable action can act upon. A verb is located in the vocabulary satisfying a criteria of the desired verb action. The verb action is performed in a context of a domain of discourse. The domain of discourse includes a set of components the performable action can act upon. The domain of discourse includes the vocabulary.

Abstract: A mask system and an air delivery conduit for use in the treatment of respiratory disorders. The air delivery conduit may comprise a textile having an airtight arrangement. A support structure may be provided to the conduit to provide form.

Abstract: An oxygen concentrator (100) may have a moisture conditioning system. In some implementations, the concentrator includes a compressor to induce feed gas into the concentrator. A first pathway may receive the feed gas from the compression system. The first pathway may be configured to draw moisture to produce moisture reduced feed gas. The first pathway may lead the moisture reduced feed gas to sieve bed(s) which produce oxygen enriched air with the moisture reduced feed gas. An accumulator may be configured to receive the produced oxygen enriched air from the sieve bed(s). A second pathway from the accumulator may apply the drawn-out moisture to the produced enriched air to produce humidified enriched air. A third pathway may transfer the drawn-out moisture from the first pathway to the second pathway. An outlet coupled with the second pathway may release the humidified enriched air from the concentrator for a user.

Abstract: A compound has the following formula: The compound is a p38 MAP kinase inhibitor. The compound and its pharmaceutically acceptable salts can be used for treatment of conditions, such as inflammatory diseases.

Abstract: The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof: The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

Abstract: A method for administering a plurality of Things in a knowledge base includes receiving a statement. A first verb action parses the statement into a parsed Thing. A second verb action evaluates the parsed Thing using a vocabulary, and computes and sets a performable statement Thing having a verb in the vocabulary representing a performable action. A third verb action performs the performable action upon a target Thing, wherein the vocabulary encompasses a set of performable action Things and a set of target Things a performable action Thing can act upon.

Abstract: A method for calibrating a quantum-computing operation comprises: (a) providing a trial control-parameter value to the quantum computer; (b) receiving from the quantum computer a result of a characterization experiment enacted according to the trial control-parameter value; (c) computing a decoder estimate of an objective function evaluated at the trial control-parameter value based on decoding the result of the characterization experiment; (d) consuming the trial control-parameter value and the decoder estimate in a machine trained to return a model estimate of the objective function evaluated at the trial control-parameter value; and (e) selecting a new trial control-parameter value based on the model estimate.

Abstract: There is described a system comprising mechanical equipment and an apparatus for monitoring and/or controlling the mechanical equipment. The mechanical equipment vibrates at a frequency fvibration in use, and the apparatus is attached to the mechanical equipment such that the apparatus also vibrates when the mechanical equipment is in use. The apparatus comprises an electronics module and a resonant electric generator. The resonant electric generator has a resonant frequency f0 comparable to the vibrational frequency fvibration of the mechanical equipment. The resonant electric generator comprises a magnet having an associated a magnetic field, a coil electrically coupled to the electronics module, and a resilient member. The resilient member is configured, when the apparatus is vibrated at or around the resonant frequency f0, to cause relative oscillation of the coil and the magnet so as to induce an electric current in the coil to thereby power the electronics module.

Abstract: A power unit with manual override control for a hydraulic system having an initial state and at least one operational state is provided, comprising: a tank for storing hydraulic fluid that moves between a first chamber and a second chamber of a hydraulic cylinder; a pump that routes the hydraulic fluid in and out of the tank; a first relief valve; a first solenoid valve configured to shift between a plurality of positions based on the at least one operational state of the hydraulic system; a first check valve connected to the first solenoid valve; a manual override control unit comprising: a second check valve; and a second solenoid valve configured to shift between a plurality of positions based on activation of a manual override control, wherein the activation of the manual override control returns the hydraulic system from the at least one operational state to the initial state.