Patents by Inventor John Kitteringham

John Kitteringham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitrosation process
    Patent number: 6596869
    Abstract: A process for preparing compounds of formula (I), by nitrosating compounds of formula (II), compounds of formula (I) having pharmaceutical activity.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Mark Jason Hughes, John Kitteringham
  • Nitrosation process
    Publication number: 20020143185
    Abstract: 1
    Type: Application
    Filed: May 30, 2002
    Publication date: October 3, 2002
    Inventors: Mark Jason Hughes, John Kitteringham
  • Novel process
    Publication number: 20020010155
    Abstract: A process for the preparation of a 4-aryl-3-oxymethyl-piperidine of structure (1) 1
    Type: Application
    Filed: August 3, 2001
    Publication date: January 24, 2002
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Mark Jason Hughes, John Kitteringham, Victor Witold Jacewicz, Gillian Elizabeth Smith, Martyn Voyle, Evgeny Shapiro
  • Enantiomer of carbazole derivative as 5-HT1-like agonists
    Patent number: 5962501
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate, or hydtrate thereof, processes for preparing said compounds and pharmaceutical compostions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: October 5, 1999
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Process for preparing enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
    Patent number: 5917054
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: January 6, 1997
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Process for the preparation of azabicyclic derivatives
    Patent number: 5808075
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R.sub.1 represents (a) in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; and R.sub.3 is CN; said process comprising reacting a compound of formula (II) wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: September 15, 1998
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Process for the preparation of azabicycloc derivatives
    Patent number: 5773619
    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; andR.sub.3 is CN;said process comprising reacting a compound of formula (II): ##STR3## wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 30, 1998
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Mark Bromidge, Martyn Voyle, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Gary Thomas Borrett
  • Derivatives of quinuclidine n-oxide as muscarinic receptor ligands
    Patent number: 5675007
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof (I) wherein R.sub.1 represents (a), R.sub.2 is a group OCH.sub.3, and R.sub.3 is cyano, for use in the treatment and/or prophylaxis of dementia in mammals.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: October 7, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventors: John Keogh, Gary Thomas Borrett, Steven Mark Bromidge, Erol Ali Faruk, Mark Jason Hughes, John Kitteringham, Martyn Voyle
  • Enantiomers of carbazole derivatives as 5-HT.sub. 1-like agonists
    Patent number: 5650426
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 22, 1997
    Assignee: SmithKline Beecham plc
    Inventors: Gary Thomas Borrett, John Kitteringham, Roderick Alan Porter, Mark Ralph Shipton, Mythily Vimal, Rodney Christopher Young
  • Process of preparing enantiomers of carbazole derivatives
    Patent number: 5618947
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: April 8, 1997
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Gary T. Borrett, John Kitteringham, Roderick A. Porter, Mark R. Shipton, Mythily Vimal, Rodney C. Young
  • Process for preparing an enantiomer of a carbazole derivative
    Patent number: 5618948
    Abstract: A (+) or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: April 8, 1997
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Gary T. Borrett, John Kitteringham, Roderick A. Porter, Mark R. Shipton, Mythily Vimal, Rodney C. Young
  • Enantiomers of carbazole derivatives as 5-HT.sub.1 -like agonists
    Patent number: 5616603
    Abstract: A (+)or (-) enantiomer of a compound of formula (I) wherein R.sup.4 is methyl or ethyl, or a salt, solvate or hydrate thereof, processes for preparing said compounds and pharmaceutical compositions containing them. Compounds of formula (+) are 5-HT.sub.1 -like agonists.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: April 1, 1997
    Assignee: SmithKline Beecham plc
    Inventors: Gary T. Borrett, John Kitteringham, Roderick A. Porter, Mark R. Shipton, Mythily Vimal, Rodney C. Young
  • Nitrosation process
    Patent number: 5545740
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: August 13, 1996
    Assignee: SmithKLine Beecham, p.l.c.
    Inventors: Mark J. Hughes, John Kitteringham
  • Process for asymmetric total synthesis of camptothecin analogues
    Patent number: 5468859
    Abstract: The present invention provides a process for the asymmetric synthesis of camptothecin analogs as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analog, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analog.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 21, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Fortunak, John Kitteringham, Nicholas Sisti, Jeffery Wood
  • Process for asymmetric total synthesis of camptothecin analogues
    Patent number: 5405963
    Abstract: The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: April 11, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Fortunak, John Kitteringham, Nicholas Sisti, Jeffery Wood
  • Process for preparing substituted pyrimidinones
    Patent number: 4569996
    Abstract: This invention provides a process for the preparation of pyrimidinone compounds with a group R.sup.2 CH(OH)-- at the 5-position thereof, wherein R.sup.2 is an optionally substituted acid-stable 5- or 6-membered nitrogen-containing heteroaryl group. The pyrimidinone ring is further substituted by a side-chain of a H.sub.1 -antagonist or H.sub.2 -antagonist or a precursor thereof.The compounds are convertible to 5-heteroaryl methyl compounds which are either useful H.sub.1 - or H.sub.2 -antagonists or precursors thereof.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: February 11, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: John Kitteringham, Brian P. Slingsby