Patents by Inventor John Knell

John Knell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo active erythropoietin produced in insect cells
    Patent number: 8026096
    Abstract: Disclosed and claimed is a human erythropoietin (EPO) expressed and produced in Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579) transfected with a baculovirus construct containing the EPO gene. The EPO has an in vivo activity of 200,000 U/mg to 500,000 U/mg.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: September 27, 2011
    Assignee: Protein Sciences Corporation
    Inventors: Gale E. Smith, John Knell, Andrei I. Voznesensky
  • Apparatus and methods for producing and using high-density cells and products therefrom
    Patent number: 7879601
    Abstract: Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579). Further disclosed is the infection of Sf900+ cells at high cell density with wild type and recombinant baculoviruses to produce baculovirus and DNA or gene or expression products.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: February 1, 2011
    Assignee: Protein Sciences Corporation
    Inventors: Gale E. Smith, John Knell, Andrei I. Voznesensky
  • APPARATUS AND METHODS FOR PRODUCING AND USING HIGH-DENSITY CELLS AND PRODUCTS THEREFROM
    Publication number: 20100159524
    Abstract: Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579). Further disclosed is the infection of Sf900+ cells at high cell density with wild type and recombinant baculoviruses to produce baculovirus and DNA or gene or expression products.
    Type: Application
    Filed: October 5, 2009
    Publication date: June 24, 2010
    Inventors: Gale E. Smith, John Knell, Andrei I. Voznesensky
  • Apparatus and methods for producing and using high-density cells and products therefrom
    Patent number: 7598075
    Abstract: Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579). Further disclosed is the infection of Sf900+ cells at high cell density with wild type and recombinant baculoviruses to produce baculovirus and DNA or gene or expression products.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 6, 2009
    Assignee: Protein Sciences Corporation
    Inventors: Gale E. Smith, John Knell, Andrei I. Voznesensky
  • Apparatus and methods for producing and using high-density cells and products therefrom
    Publication number: 20060019385
    Abstract: Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579). Further disclosed is the infection of Sf900+ cells at high cell density with wild type and recombinant baculoviruses to produce baculovirus and DNA or gene or expression products.
    Type: Application
    Filed: April 1, 2005
    Publication date: January 26, 2006
    Inventors: Gale Smith, John Knell, Andrei Voznesensky
  • Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
    Patent number: 6103526
    Abstract: Disclosed and claimed is a new insect cell line, Sf900+, ATCC CRL-12579. The insect cell line was established from Lepidoptera, Noctuidae, Spodoptera frugiperda Sf-9 (ATCC CRL-1771) through multiple rounds of limiting dilution and selection in a serum-free insect medium supplemented with added human insulin. The insect cell line is useful in BEVS or as an adjuvant and has many characteristics and advantages. Also disclosed and claimed are recombinant proteins from recombinant baculovirus expression in insect cells such as Sf900+ cells, for instance, HA, NA, EPO, CD4, CEA, and thrombospondin.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: August 15, 2000
    Assignee: Protein Sciences Corporation
    Inventors: Gale E. Smith, Harald G. Foellmer, John Knell, James DeBartolomeis, Andrei I. Voznesensky