Patents by Inventor John Knotts

John Knotts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11157837
    Abstract: A system can obtain observations from a dataset. The system can generate a set of training partitions based on the observations and generate an ensemble of machine-learning models based on the set of training partitions. The system can then receive new data and detect whether the new data is indicative of the event using the ensemble. In some cases, the system can update the ensemble by providing the new data as input to an unsupervised machine-learning model that is separate from the ensemble of machine-learning models; receiving an output from the unsupervised machine-learning model indicating whether or not the new data is indicative of the event; incorporating a new observation into the dataset indicating whether or not the new data is indicative of the event based on the output from the unsupervised machine-learning model; and updating the ensemble based on the dataset with the new observation.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: October 26, 2021
    Assignee: SAS INSTITUTE INC.
    Inventors: Yue Qi, Jeffrey Todd Miller, Jr., Thomas Francis Mutdosch, Rory David Ness MacKenzie, Iain Douglas Jackson, Peter Rowland Eastwood, Ryan Gillespie, Adam Michael Ames, Andrew John Knotts, Robert Wayne Thompson
  • Publication number: 20200042904
    Abstract: A system can obtain observations from a dataset. The system can generate a set of training partitions based on the observations and generate an ensemble of machine-learning models based on the set of training partitions. The system can then receive new data and detect whether the new data is indicative of the event using the ensemble. In some cases, the system can update the ensemble by providing the new data as input to an unsupervised machine-learning model that is separate from the ensemble of machine-learning models; receiving an output from the unsupervised machine-learning model indicating whether or not the new data is indicative of the event; incorporating a new observation into the dataset indicating whether or not the new data is indicative of the event based on the output from the unsupervised machine-learning model; and updating the ensemble based on the dataset with the new observation.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Applicant: SAS Institute Inc.
    Inventors: Yue Qi, Jeffrey Todd Miller, JR., Thomas Francis Mutdosch, Rory David Ness MacKenzie, Iain Douglas Jackson, Peter Rowland Eastwood, Ryan Gillespie, Adam Michael Ames, Andrew John Knotts, Robert Wayne Thompson
  • Publication number: 20200032324
    Abstract: Embodiments disclosed herein include devices, methods, and systems for direct, selective, and sensitive detection of single-stranded target RNA sequences from various sources using a programmed Cas13a protein. When activated by binding a target RNA sequence, the Cas13a cleaves a tether releasing a reporter molecule that may then be detected. In some embodiments, the systems, methods, and devices may include a filter or membrane that may help to separate the tethered and untethered reporter molecules. These devices, systems, and techniques allow a user to rapidly process samples that may contain the target RNA, without needing to amplify the target sequences. These devices and methods may be used to assay a wide variety of samples and target RNA sources, for the presence or absence of a specific target RNA sequence. Compositions and kits, useful in practicing these methods, for example detecting a target RNA in a biological sample, are also described.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 30, 2020
    Inventors: Ted A. Baughman, James Cate, Jennifer Doudna, Gavin John Knott, Damian Madan, Eric Nalefski, Anne-Laure M. Le Ny, Brittney Thornton
  • Patent number: 8906140
    Abstract: A filtration module is provided that includes a filter member and a spacing member disposed in detached, contact engagement along a length of each member, such length extending about a longitudinal axis of a filtration module to define a concentric and detached plurality of filtration layers, and an interleaved, concentric and detached plurality of spacing layers, respectively. One or both of the plurality of spacing layers and plurality of filtration layers may provide a radially-inward directed force. The spacing member may be elastically deformed in the filtration module to apply a radially-inward directed force and a radially-outward directed force, wherein the filtration and spacing layers are retained in substantial fixed spatial relation. A retaining member may be located to engage an external side surface of the filtration module. A filtration module may be constructed by winding the filter member and spacing member about a longitudinal axis of the module.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 9, 2014
    Assignee: W.L. Gore & Associates, Inc.
    Inventors: Steve Stark, Richard Gebert, John Knotts, John Pasmore
  • Patent number: 8712825
    Abstract: Web-based royalty system and user interface is described. In one embodiment, for example, a Web-based royalty system of the present invention is described that comprises: an interface for receiving product information comprising products subject to royalties; an interface for receiving sales data comprising sales records for the products; an interface for receiving royalty terms for the products; a calculation engine for calculating royalties due for the sales data, by matching each sales record with a given product listed in the product information, and determining for each matched product royalties due based on royalty terms applicable to sales of that product; and a statement generator for generating royalty reports of the calculated royalties.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: April 29, 2014
    Assignee: RoyaltyShare, Inc.
    Inventors: Scott A. Holcombe, Robert H. Kohn, John Knott, Ryan Daniels
  • Patent number: 8506998
    Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: August 13, 2013
    Assignee: Euro-Celtique S.A.
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
  • Publication number: 20100030607
    Abstract: A digital content management system with methodologies for lifecycle management of digital content is shown and described. In one embodiment, for example, a digital content management system is described that comprises: an ingestion module for receiving from clients various components used to create digital content releases; a polishing module for matching received components to a particular release being created; a packaging module for encoding the received components that were matched for the particular release into a digital package suitable for delivery to one or more digital content providers; and a delivery module for delivering the digital package of the particular release to one or more digital content providers.
    Type: Application
    Filed: March 24, 2009
    Publication date: February 4, 2010
    Applicant: RoyaltyShare, Inc.
    Inventors: Scott A. Holcombe, Kyle Wright, William French, Ryan Daniels, John Knott
  • Publication number: 20070098795
    Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 3, 2007
    Applicant: Euro-Celtique S.A.
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Santa Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
  • Patent number: 6882296
    Abstract: A method of encoding a digital data stream which comprises providing a first stream of clock pulses at a first rate; deriving a second stream of clock pulses from the first stream at a second rate which is an integer sub-multiple of the first rate and less than the minimum bit rate in the data stream; monitoring the data stream for changes in level therein; counting pulses in the first stream starting with the occurrence of a pulse in the second stream; capturing the pulse count when a change in level in the data stream is detected or when the next pulse in the second stream of clock pulses occurs; and upon the occurrence of this pulse in the second stream producing a time domain descriptor of the data by combining the count obtained with information as to the direction of the change in level in the data input stream.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: April 19, 2005
    Inventor: John Knott
  • Publication number: 20040174277
    Abstract: A method of encoding a digital data stream which comprises providing a first stream of clock pulses at a first rate; deriving a second stream of clock pulses from the first stream at a second rate which is an integer sub-multiple of the first rate and less than the minimum bit rate in the data stream; monitoring the data stream for changes in level therein; counting pulses in the first stream starting with the occurrence of a pulse in the second stream; capturing the pulse count when a change in level in the data stream is detected or when the next pulse in the second stream of clock pulses occurs; and upon the occurrence of this pulse in the second stream producing a time domain descriptor of the data by combining the count obtained with information as to the direction of the change in level in the data input stream.
    Type: Application
    Filed: November 6, 2003
    Publication date: September 9, 2004
    Inventor: John Knott
  • Publication number: 20020102300
    Abstract: A solid, oral, controlled release pharmaceutical dosage form comprising a pharmaceutically active ingredient having a solubility in water of greater than 1 gm in 250 ml water at 25° C., the active ingredient dispersed in a matrix wherein the dosage form provides, as tested by the Ph. Eur. Basket method at 100 rpm 900 ml aqueous buffer (pH 6.5) containing 0.05% w/w Polysorbate 80 at 37° C., an essentially zero order rate of release of the pharmaceutically active ingredient over a period of 8 hours, the amount of pharmaceutically active ingredient released over eight hours being in the range of 15% to 45%, and when tested in a group of at least five healthy humans the median tmax, based on blood sampling at half hourly intervals, is in the range of from about 2.5 to about 6 hours, and the ratio of mean Cmax to the mean plasma level at 24 hours is in the range of about 1.5 to about 3.5.
    Type: Application
    Filed: February 5, 2002
    Publication date: August 1, 2002
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Theresc Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
  • Patent number: 6399096
    Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: June 4, 2002
    Assignee: Euro-Celtique S.A.
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
  • Patent number: 6310777
    Abstract: Data recording apparatus including the plurality of removable hard disk drives (3) for recording data thereon, at least two said drives (3) being located on a removable carrier (2) which facilitates the insertion and removal thereof from the apparatus, a zero insertion force connector (4, 6) which provides electrical connections between the drives (3) on the carrier (2) and the apparatus, a switch (22) for connecting an disconnecting power to the disc drives (3) on the carrier (2), and interlock (12) for preventing the zero insertion force connector (4, 6) being connected or disconnected without the switch (22) having first been operated to disconnect power fron the disc drives (3).
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: October 30, 2001
    Inventor: John Knott
  • Publication number: 20010025256
    Abstract: A system, method, and apparatus for integrating a user's access to electronic works from multiple services or sources. The invention is preferably practiced at a content location, a host location and/or a user location. In a preferred embodiment, the user has access to works at the host through an account and access to additional works at the content location. To integrate access to works available from the host location and the content location, the content location searches its own memory for electronic works available to the user. When the search is complete, the content location transmits a message to the host. The message preferably includes user identification information needed to access the user's account with the host, an address of the content location and an identifier or work code for each work identified in the search. The message may also include some meta-data. In response, the host links the information received with the user's account.
    Type: Application
    Filed: January 17, 2001
    Publication date: September 27, 2001
    Inventors: Mike Oliphant, Dan Kaplan, John Knott
  • Publication number: 20010019725
    Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
    Type: Application
    Filed: December 19, 2000
    Publication date: September 6, 2001
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis
  • Patent number: 6162467
    Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: December 19, 2000
    Assignee: Euro-Celtique, S.A.
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis
  • Patent number: 6143328
    Abstract: Sustained release pharmaceutical formulations containing morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, suitable for administration on a once daily basis, are disclosed. In a first aspect, an orally administrable sustained release unit dosage form gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation provides a W.sub.50 for the M-6-G metabolite for morphine of between 4 and 12 hours. A third aspect concerns the pharmaceutical unit dosage form obtained by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150.degree. C.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: November 7, 2000
    Assignee: Euro-Celtique, S.A.
    Inventors: Joanne Heafield, Trevor John Knott, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Ronald Brown Miller, Derek Allan Prater, Kevin John Smith
  • Patent number: 6077532
    Abstract: A process is provided for preparing a granular pharmnaceutical ion exchange resin composition that is readily dispersible in water by granulating an ion exchange resin, having a pharmacologically active ingredient bound thereto, with a particulate sugar or sugar alcohol. The process is characterised by the use of an aqueous solution of a sugar or sugar alcohol as a granulating medium.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: June 20, 2000
    Assignee: Euro-Celtique, S.A.
    Inventors: Sandra Therese Antoinette Malkowska, Derek Allan Prater, Stewart Thomas Leslie, Adrian Brown, Trevor John Knott
  • Patent number: 6068855
    Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: May 30, 2000
    Assignee: Euro-Celtique S. A.
    Inventors: Stewart Thomas Leslie, Trevor John Knott, Hasssan Mohammad, Derek Allan Prater
  • Patent number: 5965163
    Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: October 12, 1999
    Assignee: Euro-Celtique, S.A.
    Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis