Patents by Inventor John Knotts
John Knotts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11157837Abstract: A system can obtain observations from a dataset. The system can generate a set of training partitions based on the observations and generate an ensemble of machine-learning models based on the set of training partitions. The system can then receive new data and detect whether the new data is indicative of the event using the ensemble. In some cases, the system can update the ensemble by providing the new data as input to an unsupervised machine-learning model that is separate from the ensemble of machine-learning models; receiving an output from the unsupervised machine-learning model indicating whether or not the new data is indicative of the event; incorporating a new observation into the dataset indicating whether or not the new data is indicative of the event based on the output from the unsupervised machine-learning model; and updating the ensemble based on the dataset with the new observation.Type: GrantFiled: August 2, 2019Date of Patent: October 26, 2021Assignee: SAS INSTITUTE INC.Inventors: Yue Qi, Jeffrey Todd Miller, Jr., Thomas Francis Mutdosch, Rory David Ness MacKenzie, Iain Douglas Jackson, Peter Rowland Eastwood, Ryan Gillespie, Adam Michael Ames, Andrew John Knotts, Robert Wayne Thompson
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Publication number: 20200042904Abstract: A system can obtain observations from a dataset. The system can generate a set of training partitions based on the observations and generate an ensemble of machine-learning models based on the set of training partitions. The system can then receive new data and detect whether the new data is indicative of the event using the ensemble. In some cases, the system can update the ensemble by providing the new data as input to an unsupervised machine-learning model that is separate from the ensemble of machine-learning models; receiving an output from the unsupervised machine-learning model indicating whether or not the new data is indicative of the event; incorporating a new observation into the dataset indicating whether or not the new data is indicative of the event based on the output from the unsupervised machine-learning model; and updating the ensemble based on the dataset with the new observation.Type: ApplicationFiled: August 2, 2019Publication date: February 6, 2020Applicant: SAS Institute Inc.Inventors: Yue Qi, Jeffrey Todd Miller, JR., Thomas Francis Mutdosch, Rory David Ness MacKenzie, Iain Douglas Jackson, Peter Rowland Eastwood, Ryan Gillespie, Adam Michael Ames, Andrew John Knotts, Robert Wayne Thompson
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Publication number: 20200032324Abstract: Embodiments disclosed herein include devices, methods, and systems for direct, selective, and sensitive detection of single-stranded target RNA sequences from various sources using a programmed Cas13a protein. When activated by binding a target RNA sequence, the Cas13a cleaves a tether releasing a reporter molecule that may then be detected. In some embodiments, the systems, methods, and devices may include a filter or membrane that may help to separate the tethered and untethered reporter molecules. These devices, systems, and techniques allow a user to rapidly process samples that may contain the target RNA, without needing to amplify the target sequences. These devices and methods may be used to assay a wide variety of samples and target RNA sources, for the presence or absence of a specific target RNA sequence. Compositions and kits, useful in practicing these methods, for example detecting a target RNA in a biological sample, are also described.Type: ApplicationFiled: July 30, 2018Publication date: January 30, 2020Inventors: Ted A. Baughman, James Cate, Jennifer Doudna, Gavin John Knott, Damian Madan, Eric Nalefski, Anne-Laure M. Le Ny, Brittney Thornton
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Patent number: 8906140Abstract: A filtration module is provided that includes a filter member and a spacing member disposed in detached, contact engagement along a length of each member, such length extending about a longitudinal axis of a filtration module to define a concentric and detached plurality of filtration layers, and an interleaved, concentric and detached plurality of spacing layers, respectively. One or both of the plurality of spacing layers and plurality of filtration layers may provide a radially-inward directed force. The spacing member may be elastically deformed in the filtration module to apply a radially-inward directed force and a radially-outward directed force, wherein the filtration and spacing layers are retained in substantial fixed spatial relation. A retaining member may be located to engage an external side surface of the filtration module. A filtration module may be constructed by winding the filter member and spacing member about a longitudinal axis of the module.Type: GrantFiled: October 25, 2012Date of Patent: December 9, 2014Assignee: W.L. Gore & Associates, Inc.Inventors: Steve Stark, Richard Gebert, John Knotts, John Pasmore
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Patent number: 8712825Abstract: Web-based royalty system and user interface is described. In one embodiment, for example, a Web-based royalty system of the present invention is described that comprises: an interface for receiving product information comprising products subject to royalties; an interface for receiving sales data comprising sales records for the products; an interface for receiving royalty terms for the products; a calculation engine for calculating royalties due for the sales data, by matching each sales record with a given product listed in the product information, and determining for each matched product royalties due based on royalty terms applicable to sales of that product; and a statement generator for generating royalty reports of the calculated royalties.Type: GrantFiled: July 2, 2008Date of Patent: April 29, 2014Assignee: RoyaltyShare, Inc.Inventors: Scott A. Holcombe, Robert H. Kohn, John Knott, Ryan Daniels
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Patent number: 8506998Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.Type: GrantFiled: December 18, 2006Date of Patent: August 13, 2013Assignee: Euro-Celtique S.A.Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
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Publication number: 20100030607Abstract: A digital content management system with methodologies for lifecycle management of digital content is shown and described. In one embodiment, for example, a digital content management system is described that comprises: an ingestion module for receiving from clients various components used to create digital content releases; a polishing module for matching received components to a particular release being created; a packaging module for encoding the received components that were matched for the particular release into a digital package suitable for delivery to one or more digital content providers; and a delivery module for delivering the digital package of the particular release to one or more digital content providers.Type: ApplicationFiled: March 24, 2009Publication date: February 4, 2010Applicant: RoyaltyShare, Inc.Inventors: Scott A. Holcombe, Kyle Wright, William French, Ryan Daniels, John Knott
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Publication number: 20070098795Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.Type: ApplicationFiled: December 18, 2006Publication date: May 3, 2007Applicant: Euro-Celtique S.A.Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Santa Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
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Patent number: 6882296Abstract: A method of encoding a digital data stream which comprises providing a first stream of clock pulses at a first rate; deriving a second stream of clock pulses from the first stream at a second rate which is an integer sub-multiple of the first rate and less than the minimum bit rate in the data stream; monitoring the data stream for changes in level therein; counting pulses in the first stream starting with the occurrence of a pulse in the second stream; capturing the pulse count when a change in level in the data stream is detected or when the next pulse in the second stream of clock pulses occurs; and upon the occurrence of this pulse in the second stream producing a time domain descriptor of the data by combining the count obtained with information as to the direction of the change in level in the data input stream.Type: GrantFiled: November 6, 2003Date of Patent: April 19, 2005Inventor: John Knott
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Publication number: 20040174277Abstract: A method of encoding a digital data stream which comprises providing a first stream of clock pulses at a first rate; deriving a second stream of clock pulses from the first stream at a second rate which is an integer sub-multiple of the first rate and less than the minimum bit rate in the data stream; monitoring the data stream for changes in level therein; counting pulses in the first stream starting with the occurrence of a pulse in the second stream; capturing the pulse count when a change in level in the data stream is detected or when the next pulse in the second stream of clock pulses occurs; and upon the occurrence of this pulse in the second stream producing a time domain descriptor of the data by combining the count obtained with information as to the direction of the change in level in the data input stream.Type: ApplicationFiled: November 6, 2003Publication date: September 9, 2004Inventor: John Knott
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Publication number: 20020102300Abstract: A solid, oral, controlled release pharmaceutical dosage form comprising a pharmaceutically active ingredient having a solubility in water of greater than 1 gm in 250 ml water at 25° C., the active ingredient dispersed in a matrix wherein the dosage form provides, as tested by the Ph. Eur. Basket method at 100 rpm 900 ml aqueous buffer (pH 6.5) containing 0.05% w/w Polysorbate 80 at 37° C., an essentially zero order rate of release of the pharmaceutically active ingredient over a period of 8 hours, the amount of pharmaceutically active ingredient released over eight hours being in the range of 15% to 45%, and when tested in a group of at least five healthy humans the median tmax, based on blood sampling at half hourly intervals, is in the range of from about 2.5 to about 6 hours, and the ratio of mean Cmax to the mean plasma level at 24 hours is in the range of about 1.5 to about 3.5.Type: ApplicationFiled: February 5, 2002Publication date: August 1, 2002Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Theresc Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
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Patent number: 6399096Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.Type: GrantFiled: July 27, 1998Date of Patent: June 4, 2002Assignee: Euro-Celtique S.A.Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
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Patent number: 6310777Abstract: Data recording apparatus including the plurality of removable hard disk drives (3) for recording data thereon, at least two said drives (3) being located on a removable carrier (2) which facilitates the insertion and removal thereof from the apparatus, a zero insertion force connector (4, 6) which provides electrical connections between the drives (3) on the carrier (2) and the apparatus, a switch (22) for connecting an disconnecting power to the disc drives (3) on the carrier (2), and interlock (12) for preventing the zero insertion force connector (4, 6) being connected or disconnected without the switch (22) having first been operated to disconnect power fron the disc drives (3).Type: GrantFiled: April 14, 2000Date of Patent: October 30, 2001Inventor: John Knott
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Publication number: 20010025256Abstract: A system, method, and apparatus for integrating a user's access to electronic works from multiple services or sources. The invention is preferably practiced at a content location, a host location and/or a user location. In a preferred embodiment, the user has access to works at the host through an account and access to additional works at the content location. To integrate access to works available from the host location and the content location, the content location searches its own memory for electronic works available to the user. When the search is complete, the content location transmits a message to the host. The message preferably includes user identification information needed to access the user's account with the host, an address of the content location and an identifier or work code for each work identified in the search. The message may also include some meta-data. In response, the host links the information received with the user's account.Type: ApplicationFiled: January 17, 2001Publication date: September 27, 2001Inventors: Mike Oliphant, Dan Kaplan, John Knott
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Publication number: 20010019725Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.Type: ApplicationFiled: December 19, 2000Publication date: September 6, 2001Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis
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Patent number: 6162467Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.Type: GrantFiled: August 9, 1999Date of Patent: December 19, 2000Assignee: Euro-Celtique, S.A.Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis
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Patent number: 6143328Abstract: Sustained release pharmaceutical formulations containing morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, suitable for administration on a once daily basis, are disclosed. In a first aspect, an orally administrable sustained release unit dosage form gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation provides a W.sub.50 for the M-6-G metabolite for morphine of between 4 and 12 hours. A third aspect concerns the pharmaceutical unit dosage form obtained by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35 to 150.degree. C.Type: GrantFiled: March 8, 1999Date of Patent: November 7, 2000Assignee: Euro-Celtique, S.A.Inventors: Joanne Heafield, Trevor John Knott, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Ronald Brown Miller, Derek Allan Prater, Kevin John Smith
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Patent number: 6077532Abstract: A process is provided for preparing a granular pharmnaceutical ion exchange resin composition that is readily dispersible in water by granulating an ion exchange resin, having a pharmacologically active ingredient bound thereto, with a particulate sugar or sugar alcohol. The process is characterised by the use of an aqueous solution of a sugar or sugar alcohol as a granulating medium.Type: GrantFiled: May 8, 1998Date of Patent: June 20, 2000Assignee: Euro-Celtique, S.A.Inventors: Sandra Therese Antoinette Malkowska, Derek Allan Prater, Stewart Thomas Leslie, Adrian Brown, Trevor John Knott
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Patent number: 6068855Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.Type: GrantFiled: August 18, 1997Date of Patent: May 30, 2000Assignee: Euro-Celtique S. A.Inventors: Stewart Thomas Leslie, Trevor John Knott, Hasssan Mohammad, Derek Allan Prater
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Patent number: 5965163Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.Type: GrantFiled: September 30, 1997Date of Patent: October 12, 1999Assignee: Euro-Celtique, S.A.Inventors: Ronald Brown Miller, Stewart Thomas Leslie, Sandra Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Joanne Heafield, Deborah Challis