Patents by Inventor John Kokai-Kun

John Kokai-Kun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria
    Publication number: 20080014202
    Abstract: The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.
    Type: Application
    Filed: December 19, 2006
    Publication date: January 17, 2008
    Applicant: Biosynexus Incorporated
    Inventors: Richard Schuman, John Kokai-Kun, Simon Foster, Jeffrey Stinson, Gerald Fischer
  • Neutralization of bacterial spores
    Publication number: 20070238652
    Abstract: The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., a lantibiotic-based spore decontaminant (e.g., comprising nisin)) and methods of neutralizing (e.g., killing or inhibiting growth or inhibiting germination of) bacteria (e.g., cells and spores). For example, the present invention provides nisin-based compounds (e.g., for bacterial spore decontamination) and methods of using the same in research, therapeutic and drug screening applications.
    Type: Application
    Filed: February 8, 2007
    Publication date: October 11, 2007
    Applicant: Biosynexus Incorporated
    Inventors: John Kokai-Kun, James Mond, Jonathan de la Harpe
  • Methods for testing vaccine candidates against bacterial infection in rodents
    Publication number: 20070071682
    Abstract: Methods and a rodent model to test the effectiveness of vaccine candidates against bacteria, e.g., Staphylococcus aureus by systemically immunizing a rodent, particularly a cotton rat, with a vaccine candidate, intranasally challenging the cotton rat with the selected bacteria, and detecting a response with respect to an immune response, nasal colonization as a measure of the protective effect of the vaccine candidate, or both.
    Type: Application
    Filed: August 22, 2006
    Publication date: March 29, 2007
    Inventors: John Kokai-Kun, James Mond
  • Truncated lysostaphin molecule with enhanced staphylolytic activity
    Publication number: 20050118159
    Abstract: This invention relates to the production of recombinant lysostaphin in a homogenous form through the use of recombinant DNA molecules that express homogenous lysostaphin and host cells transformed with these DNA molecules. This invention also relates to the production of truncated forms of lysostaphin. The resulting lysostaphin preparations can be administered to those at infected or risk for infection by staphylococcal bacteria.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 2, 2005
    Inventors: Jeffrey Stinson, Liouboy Grinberg, James Mond, John Kokai-Kun