Abstract: A therapeutic molecule (single chain-based antibody or ligand-based) optimized for expression and secretion from engineered T cells, which may be gamma delta (gd) T cells. When expressed from engineered gdT cells, the STAR will be secreted and mediate engagement between gdT cells and antigen/receptor on target cells. Binding mediates the formation of a cytolytic synapse between the gdT cell and the target cell leading to activation the gdT cells to release proteolytic enzymes that kill target cells.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: The present invention relates to the use of an immunogenic composition that comprises a salmonella antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection, even more preferably PCVAD. The use relates to a method comprising the steps of administering the composition to an animal in need thereof, preferably prior to disease exposure. Administration of salmonella antigen, preferably a salmonella vaccine, lessens the incidence and reduces the severity of PCVAD.

Abstract: A system for cooling charge air from a turbo- or supercharger and exhaust gas recirculated from an exhaust gas recirculation valve in an internal combustion engine. The system includes a rdiator and parallel charge air and exhaust gas heat exchanger units, the charge air heat exchanger unit having aluminum tubes and fins for air cooling the charge air, and the exhaust gas heat exchanger unit having stainless steel tubes and fins. The charge air heat exchanger and the exhaust gas heat exchanger units are each disposed adjacent the radiator, on the same or opposite sides. Alternatively, there is provided a pair of combined charge air cooler and exhaust gas cooler heat exchanger units, with a first heat exchanger unit having stainless steel tubes and fins, and a second heat exchanger unit having aluminum tubes and fins. The heat exchanger units are disposed on opposites sides of the radiator.

Abstract: A combined radiator and charge air cooler package comprises a radiator for cooling engine coolant, and a charge air cooler for cooling charge air having upper and lower portions. The upper charge air cooler portion is disposed in overlapping relationship and adjacent to the upper end of the radiator, and the lower charge air cooler portion is disposed in overlapping relationship and adjacent to the lower end of the radiator, on the face side thereof. Ambient air may flow in series through the upper end of the radiator and the upper charge air cooler portion, and through the lower charge air cooler portion and the lower end of the radiator. The charge air cooler portions are operatively connected such that the charge air may flow between the lower manifold of the upper charge air cooler portion and the upper manifold of the lower charge air cooler portion.

Abstract: A radiator includes a core for cooling a fluid, and a tank connected to the core having a side surface with a depression extending between the front and rear surfaces adapted to receive a hose and a plurality of integral ribs formed on the tank external surfaces. The radiator further includes an elongated support member having a body portion removably connected to the core and extending along a side thereof, an end portion removably connected to the tank, and a flexible expansion portion permitting relative movement between the body and end portions to reduce stress during thermal expansion and contraction of the core.

Abstract: A combined radiator and charge air cooler package includes a radiator having upper and lower portions for cooling engine coolant and a charge air cooler having upper and lower portions for cooling charge air. The upper charge air cooler portion is disposed in overlapping relationship and adjacent to the upper radiator portion, and the lower charge air cooler portion is disposed in overlapping relationship and adjacent to the lower radiator portion. The upper charge air cooler portion and the lower radiator portion are aligned in a first plane, and the lower charge air cooler portion and the upper radiator portion are aligned in a second plane, behind the first plane. Ambient cooling air may flow in series through the upper charge air cooler portion and the upper radiator portion, and also through the lower charge air cooler portion and the lower radiator portion.

Abstract: A combined radiator and charge air cooler package includes a radiator having upper and lower portions for cooling engine coolant and a charge air cooler having upper and lower portions for cooling charge air. The upper charge air cooler portion is disposed in overlapping relationship and adjacent to the upper radiator portion, and the lower charge air cooler portion is disposed in overlapping relationship and adjacent to the lower radiator portion. The upper radiator portion and the lower charge air cooler portion are aligned in a first plane, and the lower radiator portion and the upper charge air cooler portion are aligned in a second plane, behind the first plane. Ambient cooling air may flow in series through the upper radiator portion and the upper charge air cooler portion, and also through the lower charge air cooler portion and the lower radiator portion.

Abstract: A combined radiator and charge air cooler package comprises a radiator for cooling engine coolant, and a charge air cooler for cooling charge air having upper and lower portions. The upper charge air cooler portion is disposed in overlapping relationship and adjacent to the upper end of the radiator, and the lower charge air cooler portion is disposed in overlapping relationship and adjacent to the lower end of the radiator, on the face side thereof. Ambient air may flow in series through the upper end of the radiator and the upper charge air cooler portion, and through the lower charge air cooler portion and the lower end of the radiator. The charge air cooler portions are operatively connected such that the charge air may flow between the lower manifold of the upper charge air cooler portion and the upper manifold of the lower charge air cooler portion.