Abstract: A therapeutic molecule (single chain-based antibody or ligand-based) optimized for expression and secretion from engineered T cells, which may be gamma delta (gd) T cells. When expressed from engineered gdT cells, the STAR will be secreted and mediate engagement between gdT cells and antigen/receptor on target cells. Binding mediates the formation of a cytolytic synapse between the gdT cell and the target cell leading to activation the gdT cells to release proteolytic enzymes that kill target cells.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: A tube-to-header sealing system for a heat exchanger comprises a pair of mating header plates, each header plate having a wall with a plurality of openings therein and including a continuous depression along the circumference of each header plate opening which forms one-half of an O-ring groove. Each of a plurality of O-rings is positioned in each O-ring groove and the header plates are secured together such that the header plate plurality of openings are aligned and trap each of the plurality of O-rings in O-ring grooves. A plurality of spaced-apart tubes each having a tube end secured in an opening in the wall of the header to form a tube-to-header joint are expanded outwardly to provide sufficient O-ring deformation to obtain a seal. In service, the resiliency of the O-ring seal allows for expansion and contraction of the tubes without the build-up of high stresses at the tube-to-header joint.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: A modular heat exchanger assembly for ultra-large radiator applications. At least two heat exchanger cores are arranged in parallel flow, each core including inlet and outlet tanks sealingly attached to opposing headers at each end of a plurality of tubes. Each header is formed by securing mating header plates having mating openings. A plurality of O-rings are trapped within O-ring grooves formed by continuous depressions around each of the mating openings, and a portion of each tube is disposed within one of the O-rings and expanded outwardly to form a seal at each tube-to-header joint. A common tank is connected between tanks at adjacent ends of each heat exchanger core, and separate tanks are connected to the tank at the opposing ends of each core. The separate tanks may be inlet tanks and the common tank may be an outlet tank for fluid, or the flow path may be reversed.

Abstract: An industrial controller that controls operation of an industrial system. The industrial controller comprises a processor and a memory storing instruction, wherein the instructions cause the processor to perform certain functions. In particular, the instructions cause the processor to communicate high speed data in a first industrial protocol between the industrial controller and a high speed device during a first frame section but not during a second frame section of a controller frame of the industrial controller and communicate linking device data in a second industrial protocol between the industrial controller and a linking device during the second frame section but not during the first frame section or during the third frame section of the controller frame.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.

Abstract: A header for a heat exchanger manifold comprises a header plate with a periphery, a plurality of tube openings within the header plate periphery adapted to connect to tubes of a heat exchanger core, a groove around the periphery of the header plate to receive a foot of a tank, the groove comprising inner and outer vertical walls and a lower wall disposed therebetween, and a header groove reinforcement member secured to and extending along an outer surface of the header groove and along at least a portion of the length of the header plate in a direction transverse to the header groove. The header groove reinforcement member comprises a first portion extending along at least a portion of a length of the outer vertical wall in the direction of a distal end, and a second portion extending past a proximal end of the inner vertical wall and along at least a portion of the length of the header plate.

Abstract: An industrial controller that controls operation of an industrial system. The industrial controller comprises a processor and a memory storing instruction, wherein the instructions cause the processor to perform certain functions. In particular, the instructions cause the processor to communicate high speed data in a first industrial protocol between the industrial controller and a high speed device during a first frame section but not during a second frame section of a controller frame of the industrial controller and communicate linking device data in a second industrial protocol between the industrial controller and a linking device during the second frame section but not during the first frame section or during the third frame section of the controller frame.

Abstract: A tube-to-header sealing system for a heat exchanger comprises a pair of mating header plates, each header plate having a wall with a plurality of openings therein and including a continuous depression along the circumference of each header plate opening which forms one-half of an O-ring groove. Each of a plurality of O-rings is positioned in each O-ring groove and the header plates are secured together such that the header plate plurality of openings are aligned and trap each of the plurality of O-rings in O-ring grooves. A plurality of spaced-apart tubes each having a tube end secured in an opening in the wall of the header to form a tube-to-header joint are expanded outwardly to provide sufficient O-ring deformation to obtain a seal. In service, the resiliency of the O-ring seal allows for expansion and contraction of the tubes without the build-up of high stresses at the tube-to-header joint.

Abstract: A header for a heat exchanger manifold comprises a header plate with a periphery, a plurality of tube openings within the header plate periphery adapted to connect to tubes of a heat exchanger core, a groove around the periphery of the header plate to receive a foot of a tank, the groove comprising inner and outer vertical walls and a lower wall disposed therebetween, and a header groove reinforcement member secured to and extending along an outer surface of the header groove and along at least a portion of the length of the header plate in a direction transverse to the header groove. The header groove reinforcement member comprises a first portion extending along at least a portion of a length of the outer vertical wall in the direction of a distal end, and a second portion extending past a proximal end of the inner vertical wall and along at least a portion of the length of the header plate.

Abstract: A heat exchanger tube has a tube end having two extended portions substantially opposite the other around the periphery of the tube end, and two shortened portions, each positioned between the two extended portions and substantially opposite the other around the periphery of the tube end. The tube end may be formed by removing opposite portions of the tube by cutting a disc-shaped portion with a generally smoothly curving periphery along a major portion of the width of the tube. Each tube is oriented within an opening in the header wall of a heat exchanger assembly having a header portion integral with a tank portion, such that the tube end two extended portions are oriented substantially perpendicular to the direction of fluid flow within the header and the tube end two shorter portions are oriented substantially in the direction of fluid flow in order to reduce interference with fluid flow.

Abstract: A tube-to-header sealing system for a heat exchanger comprises a pair of mating header plates, each header plate having a wall with a plurality of openings therein and including a continuous depression along the circumference of each header plate opening which forms one-half of an O-ring groove. Each of a plurality of O-rings is positioned in each O-ring groove and the header plates are secured together such that the header plate plurality of openings are aligned and trap each of the plurality of O-rings in O-ring grooves. A plurality of spaced-apart tubes each having a tube end secured in an opening in the wall of the header to form a tube-to-header joint are expanded outwardly to provide sufficient O-ring deformation to obtain a seal. In service, the resiliency of the O-ring seal allows for expansion and contraction of the tubes without the build-up of high stresses at the tube-to-header joint.

Abstract: A modular heat exchanger assembly comprises at least two heat exchanger cores arranged in parallel flow, each heat exchanger core including a plurality of tubes, fins between the tubes and opposing headers sealingly attached at each end of the tubes. A common tank is positioned between the heat exchanger cores and is connected to a header at one end of each heat exchanger core, and separate tanks are connected to a header at the other end of each of the heat exchanger cores. The separate tanks may be inlet tanks for fluid passing into the heat exchanger assembly and the common tank may be an outlet tank, or the flow path may be reversed. A core support member may be disposed between each pair of heat exchanger cores to force entering air to either side of the core support member and direct air flow to the fins and tubes of the heat exchanger cores.

Abstract: Aspects of the invention include methods and systems for a testing mechanism to be utilized when repairing and replacing a valve utilized on a tank car. The testing mechanism may comprise a pipe plug device configured to plug a siphon pipe located on a tank car and a pressure test device to conduct a leak detect test after the pipe plug device is removed from the siphon pipe. The pipe plug device may include a pipe plug bladder and a pipe plug pressure fitting to inflate and deflate the pipe plug bladder against a wall of the siphon pipe. The pressure test device may include a pressure test valve cap with a test valve bladder located on the pressure test valve cap, a bladder pressure fitting to inflate and deflate the test valve bladder, and a test pressure fitting to pressurize a valve, the test pressure fitting located on the pressure test valve cap.