Abstract: Provided are methods for long term drug delivery by tattoo. The bioactive agent, which comprises the drug, is delivered to a layer, or multiple layers, of the skin. Such a method allows for long-term drug activity the bioactive agent has a longer residence time within the skin when compared to routine delivery methods. Moreover, the bioactive agent may also be combined and mixed with a coloring composition, which signals the amount of bioactive agent that has been administered and if a reapplication of the bioactive agent is necessary. Also described are methods of utilizing such a drug delivery mechanism in order to effect cosmetic changes, such as enhancing hair growth by utilizing bioactive agents suited for enabling hair growth.

Abstract: A topical composition for controlling the metabolism and/or distribution of subcutaneous fat and/or moderating the appearance of cellulite, comprising, as an active ingredient, phosphatidylcholine together with a solvent operative to maintain the phosphatidylcholine in solution, and a buffer which maintains the composition in the range of pH 7.5-9.0. Typically, the composition includes less than 10% by weight water. The composition may include further active ingredients such as xanthines. Also disclosed are methods for using the composition.

Abstract: A topical composition for controlling the metabolism and/or distribution of subcutaneous fat and/or moderating the appearance of cellulite, comprising, as an active ingredient, phosphatidylcholine together with a solvent operative to maintain the phosphatidylcholine in solution, and a buffer which maintains the composition in the range of pH 7.5-9.0. Typically, the composition includes less than 10% by weight water. The composition may include further active ingredients such as xanthines. Also disclosed are methods for using the composition.