Abstract: An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, and an end effector. The actuation assembly includes an activation member that is operable to move in a first direction to select a mode of operation. The shaft assembly extends distally from the body and includes an acoustic waveguide. The end effector includes an ultrasonic blade that is in acoustic communication with the acoustic waveguide. The activation member is operable to move in a second direction to activate the end effector in a mode of operation selected by movement of the activation member in the first direction.

Abstract: Certain aspects of the present disclosure provide a monitoring system comprising a continuous analyte sensor configured to generate a first set of analyte measurements associated with analyte levels of a host, and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the first set of analyte measurements.

Abstract: Certain aspects of the present disclosure provide a monitoring system comprising a continuous analyte sensor configured to generate a first set of analyte measurements associated with analyte levels of a patient, and a sensor electronics module coupled to the continuous analyte sensor and configured to receive and process the first set of analyte measurements.

Abstract: Provided is a process for producing a reaction product, the process comprising reacting polyisobutylene with a radical initiator and an ethylenically unsaturated acylating agent at a reaction temperature of from 150° C. to 225° C. to produce the reaction product, wherein the polyisobutylene is brought to the reaction temperature prior to addition of the radical initiator; and wherein the ethylenically unsaturated acylating agent is added at any time prior to or during addition of the radical initiator.

Abstract: A vascular anastomotic coupling device includes, for each of two vessels prepared for anastomosis, an inner ring sized to slide over an outer diameter of one of the two vessels. An outer ring is configured to trap an everted portion of the one of the two vessels between itself and the inner ring. Interface features on the inner ring and outer ring are configured to trap and hold the everted portion of the one of the two vessels between them and fix a position of the inner ring and outer ring with respect to each other. A connection interface on the outer ring is configured, when mounted on the one of the two vessels, to join with the outer ring of the other of the two vessels to join the two vessels and complete anastomosis of the two vessels.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present disclosure describes a system and method for holding or storing items. The system includes a pad, a weight sensor, a shape sensor, a memory, and a processor communicatively coupled to the memory. The weight sensor detects a weight of an item when the item is positioned on the pad. The shape sensor detects a shape of the item when the item is positioned on the pad. The processor verifies that the item is positioned on the pad based on the detected weight and the detected shape and communicates a message that the item is positioned on the pad.

Abstract: A transmitter including a frequency synthesizer with a voltage-controlled oscillator that provides an oscillating signal, a programmable delay circuit that delays the oscillating signal to provide a delayed oscillating signal, a power amplifier that is configured to amplify the delayed oscillating signal for transmission sufficient to produce interference, and a delay controller that programs the delay circuit with a delay time that reduces interference caused by coupling from the power amplifier to the voltage-controlled oscillator. The delay circuit may be programmed to reduce control voltage change of the voltage-controlled oscillator as a function of delay change, and/or to reduce phase noise degradation at an output of the transmitter as a function of delay change. The delay may be adjusted based on detected operating temperature. A calibration value may be determined at a calibration frequency, in which a frequency offset may be determined based on a selected channel frequency.

Abstract: An earth boring cutting insert including a cemented carbide comprising metal carbide grains dispersed in a metallic binder including at least one of platinum, palladium, rhenium, rhodium, and ruthenium.

Abstract: Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5?-untranslated and 3?-untranslated region, which is substituted with a 5-? and 3?-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described.

Abstract: A network for managing account addresses (such as for credit card accounts) where correspondence and other communications mailed to account holders may have different purposes (e.g., credit card statement, new credit card, marketing correspondence). The network has a database for storing addresses and a database management system for retrieving those addresses. A default address is provided when there is no address stored in the database for the intended purpose of a mailing. The addresses are in categories, with each category associated with a different communication purpose, and with multiple addresses in each category. The multiple addresses within each category may be permanent, temporary or repeating. If temporary or repeating, effective start and end dates are associated with the addresses. There may be multiple cardholders for each account, in which case the address categories (and multiple addresses within each category) are associated with each cardholder.

Abstract: A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.

Abstract: Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5?-untranslated and 3?-untranslated region, which is substituted with a 5-? and 3?-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described.

Abstract: A network for managing account addresses (such as for credit card accounts) where correspondence and other communications mailed to account holders may have different purposes (e.g., credit card statement, new credit card, marketing correspondence). The network has a database for storing addresses and a database management system for retrieving those addresses. A default address is provided when there is no address stored in the database for the intended purpose of a mailing. The addresses are in categories, with each category associated with a different communication purpose, and with multiple addresses in each category. The multiple addresses within each category may be permanent, temporary or repeating. If temporary or repeating, effective start and end dates are associated with the addresses. There may be multiple cardholders for each account, in which case the address categories (and multiple addresses within each category) are associated with each cardholder.

Abstract: A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.

Abstract: An optical system utilizing phosphors to perform mathematical operations without the direct or necessary use of an electronic component or electrical power source is disclosed. The luminenscent and quenching properties of phosphors are combined with at least one first-order relaxation subsystem such that when the optical system achieves equilibrium, it will have performed certain mathematical operations. The precise mathematical operation to be performed is determined by controlling the materials utilized, light inputs, and certain variables within the optical system.

Abstract: A method and an apparatus for measuring the density variations, static and dynamic, in substances that are at least partially transparent to electromagnetic waves is disclosed. A special birefringement crystal phase shifting assembly encodes the angle of incidence resulting from the refractive effects of the electromagnetic waves having passed through a density variation. The angle of incidence is encoded as a poralization phase shift. Specifically, the poralization phase shift is between the ordinary and the extraordinary rays. That poralization phase shift has a known and definable relationship to the gas density experienced by the electromagnetic wave during its path.

Abstract: A method and an apparatus for measuring the density variations, static and dynamic, in substances that are at least partially transparent to electromagnetic waves is disclosed. A special birefringement crystal phase shifting assembly encodes the angle of incidence resulting from the refractive effects of the electromagnetic waves having passed through a density variation. The angle of incidence is encoded as a poralization phase shift. Specifically, the poralization phase shift is between the ordinary and the extraordinary rays. That poralization phase shift has a known and definable relationship to the gas density experienced by the electromagnetic wave during its path.

Abstract: A network for managing account addresses (such as for credit card accounts) where correspondence and other communications mailed to account holders may have different purposes (e.g., credit card statement, new credit card, marketing correspondence). The network has a database for storing addresses and a database management system for retrieving those addresses. A default address is provided when there is no address stored in the database for the intended purpose of a mailing. The addresses are in categories, with each category associated with a different communication purpose, and with multiple addresses in each category. The multiple addresses within each category may be permanent, temporary or repeating. If temporary or repeating, effective start and end dates are associated with the addresses. There may be multiple cardholders for each account, in which case the address categories (and multiple addresses within each category) are associated with each cardholder.