Patents by Inventor John L. Killmer

John L. Killmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230416744
    Abstract: The invention provides methods and compositions for improved production of large quantities of unencapsidated double strand RNA (dsRNA) in vivo. The disclosed methods and compositions, comprising co-expression of genes encoding orotate phosporibosyl transferase, bacteriophage coat protein and dsRNA produce a significant improvement over current in vivo methods of producing unencapsidated dsRNA.
    Type: Application
    Filed: June 27, 2023
    Publication date: December 28, 2023
    Applicant: RNAISSANCE AG LLC
    Inventors: John L. KILLMER, Patrick D. McLAUGHLIN, Juan Pedro Humberto ARHANCET
  • Patent number: 11718851
    Abstract: The invention provides methods and compositions for improved production of large quantities of unencapsidated double strand RNA (dsRNA) in vivo. The disclosed methods and compositions, comprising co-expression of genes encoding orotate phosporibosyl transferase, bacteriophage coat protein and dsRNA produce a significant improvement over current in vivo methods of producing unencapsidated dsRNA.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: August 8, 2023
    Inventors: John L. Killmer, Patrick D. McLaughlin, Juan Pedro Humberto Arhancet
  • Publication number: 20220304315
    Abstract: Methods and materials for improved delivery of dsRNA are presented. In particular, methods for controlling an insect pest by stably delivering large quantities of dsRNA to the insect pest are provided. Compositions comprising a bacterium containing a large quantity of dsRNA targeting an insect gene in which the dsRNA exhibits increased stability and activity are also provided.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 29, 2022
    Applicant: RNAISSANCE AG LLC
    Inventors: John L. Killmer, Anil Kumar
  • Publication number: 20220145294
    Abstract: The invention provides methods and compositions for improved production of large quantities of unencapsidated double strand RNA (dsRNA) in vivo. The disclosed methods and compositions, comprising co-expression of genes encoding orotate phosporibosyl transferase, bacteriophage coat protein and dsRNA produce a significant improvement over current in vivo methods of producing unencapsidated dsRNA.
    Type: Application
    Filed: July 7, 2020
    Publication date: May 12, 2022
    Applicant: APSE, INC.
    Inventors: John L. KILLMER, Patrick D. McLAUGHLIN, Juan Pedro Humberto ARHANCET
  • Publication number: 20210127683
    Abstract: The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming Virus Like Particles (VLPs) suitable for insect control applications.
    Type: Application
    Filed: October 20, 2020
    Publication date: May 6, 2021
    Applicant: APSE, INC.
    Inventors: John L. Killmer, Juan Pedro Humberto Arhancet, Patrick D. McLaughlin
  • Patent number: 10806150
    Abstract: The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming Virus Like Particles (VLPs) suitable for insect control applications. Specifically, the disclosure provides a method for controlling target insects comprising, transforming a microbial host with a first DNA sequence comprising a gene encoding a bacteriophage capsid protein and a second DNA sequence encoding an RNA transcript comprising at least one bacteriophage pac sequence coupled to an RNAi precursor sequence, inducing the microbial host to express the first and second DNA sequences, isolating virus-like-particles (VLPs) comprising the capsid protein and RNAi precursor from the microbial host, and contacting the isolated VLPs with the target insects.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: October 20, 2020
    Assignee: APSE, INC.
    Inventors: John L. Killmer, Juan Pedro Humberto Arhancet, Patrick D. McLaughlin
  • Patent number: 10704045
    Abstract: Methods and materials for improved in vivo production of dsRNA are presented. Yields of dsRNA are significantly increased in the presence of capsid protein. The improved yield of dsRNA is not dependent on the presence of specific cognate binding sites for capsid protein associated with the dsRNA, but is dependent on capsid protein.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 7, 2020
    Assignee: APSE, INC.
    Inventors: John L. Killmer, Patrick D. McLaughlin, Juan Pedro Humberto Arhancet
  • Publication number: 20190093108
    Abstract: Methods and materials for improved in vivo production of dsRNA are presented. Yields of dsRNA are significantly increased in the presence of capsid protein. The improved yield of dsRNA is not dependent on the presence of specific cognate binding sites for capsid protein associated with the dsRNA, but is dependent on capsid protein.
    Type: Application
    Filed: March 9, 2017
    Publication date: March 28, 2019
    Applicant: APSE, INC.
    Inventors: John L. KILLMER, Patrick D. McLAUGHLIN, Juan Pedro Humberto ARHANCET
  • Publication number: 20190029265
    Abstract: The invention describes recombinant sequences and methods for producing RNAs suitable for controlling proliferation of ant species, including Solenopsis, Camponotus, Linepithema, Tapinoma, Tetramorium, and Monomorium spp.
    Type: Application
    Filed: January 31, 2017
    Publication date: January 31, 2019
    Applicant: APSE, INC.
    Inventors: John L. KILLMER, Anil KUMAR, Patrick D. McLAUGHLIN, Juan Pedro Humberto ARHANCET
  • Publication number: 20180368422
    Abstract: The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming Virus Like Particles (VLPs) suitable for insect control applications. Specifically, the disclosure provides a method for controlling target insects comprising, transforming a microbial host with a first DNA sequence comprising a gene encoding a bacteriophage capsid protein and a second DNA sequence encoding an RNA transcript comprising at least one bacteriophage pac sequence coupled to an RNAi precursor sequence, inducing the microbial host to express the first and second DNA sequences, isolating virus-like-particles (VLPs) comprising the capsid protein and RNAi precursor from the microbial host, and contacting the isolated VLPs with the target insects.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 27, 2018
    Applicant: APSE, INC.
    Inventors: John L. Killmer, Juan Pedro Humberto Arhancet, Patrick D. McLaughlin
  • Patent number: 6127318
    Abstract: A composition comprising N-(phosphonomethyl)glycine or a salt thereof and a triazolinone herbicide is described. The composition can optionally comprise inert ingredients such as a surfactant, an emulsifier, a solvent, or a carrier. Triazolinone herbicides of particular interest in this composition include carfentrazone-ethyl and sulfentrazone.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 3, 2000
    Assignee: Monsanto Company
    Inventors: Tatsuo Sato, Masuo Kuchikata, Yoo Yong-Man, Kathleen S. Cearnal, John L. Killmer