Patents by Inventor John L. Klepeis

John L. Klepeis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of ab initio prediction of &agr; helices, &bgr; sheets, and polypeptide tertiary structures
    Patent number: 6832162
    Abstract: The present invention provides a novel four stage ab initio approach for predicting the tertiary structure of polypeptides. The methods of the invention combine the classical and modern views of protein folding, while using free energy calculations and integer linear optimization to predict helical and &bgr;-sheet structures. Derivation of restraints, detailed atomistic modeling, and a deterministic global optimization method, &agr;BB, coupled with torsion angle dynamics, form the basis for the final tertiary structure prediction. The performance of the methods of the invention is illustrated using several different polypeptides.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: December 14, 2004
    Assignee: The Trustees of Princeton University
    Inventors: Christodoulos A. Floudas, John L. Klepeis
  • Methods of ab initio prediction of alpha helices, beta sheets, and polypeptide tertiary structures
    Publication number: 20030036093
    Abstract: The present invention provides a novel four stage ab initio approach for predicting the tertiary structure of polypeptides. The methods of the invention combine the classical and modem views of protein folding, while using free energy calculations and integer linear optimization to predict helical and &bgr;-sheet structures. Derivation of restraints, detailed atomistic modeling, and a deterministic global optimization method, &agr;BB, coupled with torsion angle dynamics, form the basis for the final tertiary structure prediction. The performance of the methods of the invention is illustrated using several different polypeptides.
    Type: Application
    Filed: February 16, 2001
    Publication date: February 20, 2003
    Inventors: Christodoulos A. Floudas, John L. Klepeis