Patents by Inventor John L. Knopf

John L. Knopf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf
  • Arachidonic acid releasing phospholipase A2 enzyme and methods of use
    Patent number: 5622832
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 22, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Recombinant phospholipase A.sub.2 enzyme
    Patent number: 5593878
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Recombinant phospholipase A.sub.2 enzyme
    Patent number: 5527698
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: June 18, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Intracellular phospholipase A.sub.2 enzyme
    Patent number: 5354677
    Abstract: The-invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: October 11, 1994
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • DNA sequences encoding phospholipase A.sub.2 enzyme and processes for producing enzyme
    Patent number: 5322776
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: June 21, 1994
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark