Patents by Inventor John L. Markley

John L. Markley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for determining compound concentrations in a mixture using regression of NMR intensity peak values
    Patent number: 7847547
    Abstract: A method of determining a concentration level of a compound in a mixture is provided. A plurality of compounds are identified in the mixture based on intensity peaks identified from NMR data generated from the mixture. A compound is selected from the identified plurality of compounds for a concentration determination. A concentration equation associated with the selected compound is determined. A first peak associated with the selected compound is selected from the NMR data. The selected first peak does not overlap with a peak associated with another compound of the identified plurality of compounds. An intensity value associated with the selected first peak is determined. A concentration of the selected compound in the mixture is calculated using the determined concentration equation and the determined intensity value.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: December 7, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John L. Markley, Ian A. Lewis, William M. Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli
  • METHOD AND SYSTEM FOR DETERMINING COMPOUND CONCENTRATIONS IN A MIXTURE
    Publication number: 20090192725
    Abstract: A method of determining a concentration level of a compound in a mixture is provided. A plurality of compounds are identified in the mixture based on intensity peaks identified from NMR data generated from the mixture. A compound is selected from the identified plurality of compounds for a concentration determination. A concentration equation associated with the selected compound is determined. A first peak associated with the selected compound is selected from the NMR data. The selected first peak does not overlap with a peak associated with another compound of the identified plurality of compounds. An intensity value associated with the selected first peak is determined. A concentration of the selected compound in the mixture is calculated using the determined concentration equation and the determined intensity value.
    Type: Application
    Filed: January 30, 2008
    Publication date: July 30, 2009
    Inventors: John L. Markley, Ian A. Lewis, William M. Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli
  • Protein sweetener
    Patent number: 7153535
    Abstract: Disclosed herein are sweet proteins that are variants of Brazzein, and nucleotide sequences capable of expressing them. Through a replacement of a particular amino acid in the naturally occurring Brazzein sequence with Lys or Asn, the taste profile and sweetness strength are improved.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: December 26, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zheyuan Jin, John L. Markley, Fariba M. Assadi-Porter, Bengt G. Hellekant
  • Protein sweetener
    Publication number: 20040018290
    Abstract: Disclosed herein are sweet proteins that are variants of Brazzein, and nucleotide sequences capable of expressing them. Through a replacement of a particular amino acid in the naturally occurring Brazzein sequence with Lys or Asn, the taste profile and sweetness strength are improved.
    Type: Application
    Filed: April 3, 2003
    Publication date: January 29, 2004
    Inventors: Zheyuan Jin, John L. Markley, Fariba M. Assadi-Porter, Bengt G. Hellekant
  • Protein sweetener
    Patent number: 6274707
    Abstract: Disclosed herein are sweet proteins that are variants of Brazzein, and nucleotide sequences capable of expressing them. Through a replacement of an amino acid in the naturally occurring Brazzein sequence with Arg or Ala (or the addition of Arg or Ala), the taste profile and sweetness strength can be changed.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: August 14, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John L. Markley, Fariba M. Assadi-Porter