Patents by Inventor John L. Middlebrook

John L. Middlebrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant vaccine against botulinum neurotoxin
    Patent number: 7786285
    Abstract: This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as well as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: August 31, 2010
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Leonard A. Smith, Michael P. Byrne, John L. Middlebrook, Hugh Lapenotiere, Michael A. Clayton, Douglas R. Brown
  • Recombinant vaccine against botulinum neurotoxin
    Patent number: 7214787
    Abstract: This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as weel as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: May 8, 2007
    Assignee: United States of America as Represented by the Secretary of the Army
    Inventors: Leonard A. Smith, Michael P. Byrne, John L. Middlebrook, Hugh Lapenotiere, Michael A. Clayton, Douglas R. Brown
  • Recombinant vaccine against botulinum neurotoxin
    Patent number: 7081529
    Abstract: This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as weel as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: July 25, 2006
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Leonard A. Smith, Michael P. Byrne, John L. Middlebrook, Hugh Lapenotiere, Michael A. Clayton, Douglas R. Brown
  • Recombinant vaccine against botulinum neurotoxin
    Publication number: 20030009025
    Abstract: This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as weel as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 9, 2003
    Inventors: Leonard A. Smith, Michael P. Byrne, John L. Middlebrook, Hugh Lapenotiere, Michael A. Clayton, Douglas R. Brown