Patent number: 5256781
Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is O, S, NR.sup.6, --CR.sup.7 .dbd.CR.sup.8 --;Z is O, S, NR.sup.6, --CR.sup.7 .dbd.CR.sup.8 --;X is H, NR.sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;when Z=--CR.sup.7 .dbd.CR.sup.8 -- then Y is NR.sup.13, NR.sup.13 CR.sup.12 R.sup.14 ; CR.sup.12 R.sup.14 NR.sup.13 ;when Z.dbd.O, S, NR.sup.6 then Y is NR.sup.13 CR.sup.12 R.sup.14 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3, R.sup.4, R.sup.7, R.sup.8 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11, F, Cl, Br, I, NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.
Type:
Grant
Filed:
March 22, 1993
Date of Patent:
October 26, 1993
Assignee:
American Home Products Corporation
Inventors:
John L. Primeau, Lloyd M. Garrick
Patent number: 5236925
Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is O, S, NR.sup.6 ;Z is O, S, NR.sup.6 ;X is H, NR.sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;Y is NR.sup.13 CR.sup.12 R.sup.14 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3, R.sup.4, R.sup.7, R.sup.8 is H, alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11, F, Cl, Br, I, NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;R.sup.6 is H, alkyl, aralkyl;R.sup.9, R.sup.10 is H, alkyl, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl;R.sup.11 is H, alkyl, aralkyl, alkoxyalkyl;R.
Type:
Grant
Filed:
August 6, 1992
Date of Patent:
August 17, 1993
Assignee:
American Home Products Corporation
Inventors:
John L. Primeau, Lloyd M. Garrick
Patent number: 5234936
Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein X is H, NR.sup.12 R.sup.13, OR.sup.14, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13 ;Y is NR.sup.15, NR.sup.18 CR.sup.16 R.sup.17, CR.sup.16 R.sup.17 NR.sup.15 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.14, SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2, R.sup.3 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.19, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13, OR.sup.14, F, Cl, Br, I, NR.sup.12 R.sup.13 ;R.sup.4 -R.sup.11 is H, F, alkyl, alkoxy, alkoxyalkyl, --OCOR.sup.14, alkyl-OH, perfluoroalkyl, aralkyl, aryl, CN, NO.sub.2, SO.sub.2 R.sup.19, --(CH.sub.2).sub.n CO.sub.2 R.sup.14, --(CH.sub.2).sub.n CONR.sup.12 R.sup.13, OH, OR.sup.14, --NR.sup.12 R.sup.13, any two geminal groups can be O or CH.sub.2 ;R.sup.12, R.sup.
Type:
Grant
Filed:
October 24, 1991
Date of Patent:
August 10, 1993
Assignee:
American Home Products Corporation
Inventors:
John L. Primeau, Lloyd M. Garrick, Timothy D. Ocain, Richard M. Soll, Paul J. Dollings
Patent number: 5187168
Abstract: There are disclosed compounds of the general formula I: ##STR1## wherein A is --CR.sup.7 .dbd.CR.sup.8 --;Z is --CR.sup.7 .dbd.CR.sup.8 --;X is H, NR .sup.9 R.sup.10, OR.sup.11, CN, F, Cl, I, Br, perfluoroalkyl, alkyl,alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.11,--(CH.sub.2).sub.n CONR.sup.9 R.sup.10 ;Y is NR.sup.13,NR.sup.13 CR.sup.12 R.sup.14, CR.sup.12 R.sup.14 NR.sup.13 ;R.sup.1 is 5-tetrazolyl, CO.sub.2 R.sup.11,SO.sub.3 H, NHSO.sub.2 CH.sub.3, NHSO.sub.2 CF.sub.3 ;R.sup.2,R.sup.3,R.sup.4,R.sup.7 R.sup.8 is H, alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, CN, NO.sub.2, SO.sub.2 R.sup.13, --(CH.sub.2).sub.n CO.sub.2 R.sup.11,--(CH.sub.2).sub.n CONR.sup.9 R.sup.10, OR.sup.11,F,Cl,Br,I,NR.sup.9 R.sup.10 ;R.sup.5 is alkyl, alkoxy, alkoxyalkyl, alkyl-OH, perfluoroalkyl, aralkyl, H, --CN, NO.sub.2, SO.sub.2 R.sup.13,--(CH.sub.2).sub.n CO.sub.2 R.sup.11, --(CH.sub.2).sub.n CONR.sup.9 R.sup.10, --OH,OR.sup.11,F,Cl,Br,I,NR.sup.9 R.sup.10 ;R.sup.9,R.sup.
Type:
Grant
Filed:
October 24, 1991
Date of Patent:
February 16, 1993
Assignee:
American Home Products Corporation
Inventors:
John L. Primeau, Lloyd M. Garrick