Abstract: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

Abstract: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

Abstract: The present invention provides a method for testing an agent for its potential to inhibit heparanase catalytic activity, comprising the steps of: interacting immobilized heparanase substrate binding protein on a solid support with labeled heparanase substrate to provide immobilized labeled heparanase substrate, interacting a heparanase enzyme solution with the immobilized labeled heparanase substrate in the presence of the agent, and detecting the presence or absence of label in the solution remote from the solid support. The labeled heparanase substrate may be bound to an immobilization bridge which binds to immobilized molecules on a solid support, to provide bridge-immobilized labeled heparanase substrate.

Abstract: A tamper-proof locking mechanism for a rotatable control device, such as a quarter turn valve, including a valve member connected to a stem rotatably mounted in a body housing the valve member and an operating handle connected to the stem via an elongated extension for rotating the valve member between open and closed positions. The locking mechanism includes a bracket mounted on the body and having a flange spaced outwardly from the body and generally perpendicularly to the rotational axis of the stem and including an aperture through which the extension extends and a pair of circumferentially spaced projections extending radially outwardly relative to the rotational axis of the stem at locations corresponding to the open and closed positions of the valve member.

Abstract: A method and apparatus which provides a bearing design with an irregular or semi-rhythmic ball spacing. The method of the invention includes the steps of a) choosing an initial pattern for the position of the balls with an arbitrary irregular spacing therebetween; b) determining the degree to which the bearing is suitable for a given application with the chosen spacing between the balls; c) moving the balls in the pattern to change the spacing therebetween and d) repeating steps b) and c) until the bearing is suitable for a given application.

Abstract: A rotatable control device or valve including a body housing a control mechanism and a rotatably mounted control shaft connected to the control mechanism. Stops are spaced circumferentially relative to the control shaft. A stop arm is operably connected to the control shaft and engages the stops to limit rotational movement of the control mechanism between first and second positions. An elongated extension is drivingly connected to the stop arm, and an elongated operating handle is connected to the extension with the orientation of the longitudinal axis of the operating handle corresponding in a predetermined relationship to the position of the control member. A registration mechanism permits the extension to be drivingly connected to the stop arm only when the orientation of the longitudinal axis of the operating handle corresponds in the predetermined relationship to the position of the control means.

Abstract: A motor vehicle power steering gear having a spool shaft connected to a steering wheel, a pinion head connected to a steered wheel, a torsion bar between the spool shaft and the pinion head, a control valve for regulating a hydraulic steering assist boost pressure in response to rotation of the spool shaft from an on-center position relative to the pinion head against a restoring force of the torsion bar, and a quiet preload apparatus including a C-shaped spring around the spool shaft having a pair of resilient jaws, a drive pin on the spool shaft clamped with a preload between the resilient jaws, and a cushioned abutment on the pinion head clamped with the preload between the resilient jaws.

Abstract: A rotatable control device including a body housing a control structure and having an external box; a control shaft journalled in the boss for rotation about an axis and having an internal portion connected to the control structure and an external portion extending outwardly from the boss; an operating handle having an inner end portion connected to the external portion of the control shaft, a gripping end portion for rotating the control structure between first and second positions and an intermediate portion; first and second locking structure circumferentially spaced on the body at locations corresponding to the positions of the intermediate portion of the handle when the control structure is in the first and second positions, respectively; a slider member slidably mounted on the intermediate portion of the handle for reciprocative movement between locked and unlocked positions; interlocking structure for cooperating with the first and second locking structure, when the handle is in the first and second po

Abstract: Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity;R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.

Abstract: Antibacterial compounds of the formula ##STR1## in which R.sub.1 is a cyclic or secondary acyclic amino group which independently has antibacterial activity:R.sub.2 is hydrogen, lower alkoxy, lower alkylthio or formamido;R.sub.3 is hydrogen or an organic group bonded through carbon, oxygen, sulfur or nitrogen;R.sub.4 is an electronegative acidic group; or R.sub.3 and R.sub.4 together form a heterocycle; andR.sub.5 is a hydrogen or lower alkyl, except when R.sub.3 and R.sub.4 form a heterocycle, in which case R.sub.5 is hydrogen only; and methods of using same.

Abstract: A tamper-proof locking mechanism for a rotatable control device, such as a quarter turn valve including a valve member connected to a stem journalled in a body housing the valve member and an operating handle connected to the stem for rotating the valve member between open and closed positions. The locking mechanism includes a pair of lugs on the valve body at circumferentially spaced locations corresponding to the locations of an intermediate portion of the handle when the valve member is in the open and closed positions. A slider member is slidably mounted on the intermediate portion of the handle for reciprocative movement between a locked position and an unlocked position. The slider member includes a latch element having an open portion for receiving the lugs and arranged to restrain both rotational and axial movement of the handle when the handle is in the open or closed position and the slider member is in the locked position.

Abstract: An advertising or promotional item comprises a body (2) from one side of which extends a flag (3) carrying an advertising message, the body (2) having a foot (1) by which it may be adhered to a support. According to the invention the body (2) is a flattened mass of fibers (5), so that the item is small enough to be posted in an envelope in the mail. A face (4) may be adhered to the body (2) to keep the item flat.