Patents by Inventor John L. Rubenstein

John L. Rubenstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro production of medial ganglionic eminence precursor cells
    Patent number: 11884932
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: January 30, 2024
    Assignee: The Regents of the University of California
    Inventors: Cory R. Nicholas, John L. Rubenstein, Arnold R. Kriegstein, Arturo Alvarez-Buylla
  • In Vitro Production of Medial Ganglionic Eminence Precursor Cells
    Publication number: 20210040443
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Application
    Filed: July 24, 2020
    Publication date: February 11, 2021
    Inventors: Cory R. NICHOLAS, John L. RUBENSTEIN, Arnold R. KRIEGSTEIN, Arturo ALVAREZ-BUYLLA
  • In vitro production of medial ganglionic eminence precursor cells
    Patent number: 10760048
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Cory R. Nicholas, John L. Rubenstein, Arnold R. Kriegstein, Arturo Alvarez-Buylla
  • In Vitro Production of Medial Ganglionic Eminence Precursor Cells
    Publication number: 20190062700
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Application
    Filed: September 10, 2018
    Publication date: February 28, 2019
    Inventors: Cory R. NICHOLAS, John L. RUBENSTEIN, Arnold R. KRIEGSTEIN, Arturo ALVAREZ-BUYLLA
  • In vitro production of medial ganglionic eminence precursor cells
    Patent number: 10100279
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 16, 2018
    Assignee: The Regents of the University of California
    Inventors: Cory R. Nicholas, John L. Rubenstein, Arnold R. Kriegstein, Arturo Alvarez-Buylla
  • Transplantation of neural cells
    Patent number: 9713628
    Abstract: Restoration or increase of inhibitory interneuron function in vivo is achieved by transplantation of MGE cells into the brain. Compositions containing MGE cells are provided as are uses to treat various diseases characterized by abnormal inhibitory interneuron function or in cases where increase inhibition may ameliorate neural circuits that are abnormally activated.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: July 25, 2017
    Assignee: The Regents of the University of California
    Inventors: Scott C. Baraban, John L. Rubenstein, Arturo Alvarez-Buylla
  • Transplantation of Neural Cells
    Publication number: 20160008403
    Abstract: Restoration or increase of inhibitory interneuron function in vivo is achieved by transplantation of MGE cells into the brain. Compositions containing MGE cells are provided as are uses to treat various diseases characterised by abnormal inhibitory interneuron function or in cases where increase inhibition may ameliorate neural circuits that are abnormally activated.
    Type: Application
    Filed: September 8, 2015
    Publication date: January 14, 2016
    Inventors: Scott C. Baraban, JOHN L. RUBENSTEIN, Arturo Alvarez-Buylla
  • In Vitro Production of Medial Ganglionic Eminence Precursor Cells
    Publication number: 20150361393
    Abstract: Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems provide efficient production of MGE precursors. The methods and systems disclosed herein provide functional MGE precursors which differentiate into functional GABAergic interneurons.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 17, 2015
    Inventors: Cory R. NICHOLAS, John L. RUBENSTEIN, Arnold R. KRIEGSTEIN, Arturo ALVAREZ-BUYLLA
  • Transplantation of neural cells
    Patent number: 9192630
    Abstract: Restoration or increase of inhibitory interneuron function in vivo is achieved by transplantation of MGE cells into the brain. Compositions containing MGE cells are provided as are uses to treat various diseases characterised by abnormal inhibitory interneuron function or in cases where increase inhibition may ameliorate neural circuits that are abnormally activated.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: November 24, 2015
    Assignee: The Regents of the University of California
    Inventors: Scott C. Baraban, John L. Rubenstein, Arturo Alvarez-Buylla
  • TRANSPLANTATION OF NEURAL CELLS
    Publication number: 20090311222
    Abstract: Restoration or increase of inhibitory interneuron function in vivo is achieved by transplantation of MGE cells into the brain. Compositions containing MGE cells are provided as are uses to treat various diseases characterised by abnormal inhibitory interneuron function or in cases where increase inhibition may ameliorate neural circuits that are abnormally activated.
    Type: Application
    Filed: January 18, 2007
    Publication date: December 17, 2009
    Inventors: Scott C. Baraban, John L. Rubenstein, Arturo Alvarez-Buylla
  • Production of gabaergic cells
    Patent number: 6602680
    Abstract: The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: August 5, 2003
    Assignee: The Regents of the University of California
    Inventors: John L. Rubenstein, Marina Mione, Stewart Anderson, Thorsten Stuehmer, Kyuson Yun
  • Production of gabaergic cells
    Publication number: 20020151066
    Abstract: The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx gene (e.g., DLX1, DLX2, or DLX5) in an immature neuronal cell. The increase in Dlx activity causes differentiation of the immature neuronal cell into a neuronal cell exhibiting the GABAergic phenotype. The invention also encompasses use of GABAergic cells produced by the method of the invention in, for example, identification of agents that affect GABAergic cell activity and survival, and in replacement therapy.
    Type: Application
    Filed: July 5, 2001
    Publication date: October 17, 2002
    Inventors: John L. Rubenstein, Marina Mione, Stewart Anderson, Thorsten Stuehmer, Kyuson Yun