Abstract: The present invention is an accelerated conformational sampling method for predicting target peptide and protein structures comprising a process of determining energy minimized synthetic templates using a simple system for modeling individual molecular bonds within the subject peptide or protein. Use of these synthetic templates greatly reduces the computational resources necessary for optimally determining structural features of the target peptide or protein. The present invention also provides methods for rapid and efficient analysis of the effect of mutations on target peptides and proteins.

Abstract: The present invention is an accelerated conformational sampling method for predicting target peptide and protein structures comprising a process of determining energy minimized synthetic templates using a simple system for modeling individual molecular bonds within the subject peptide or protein. Use of these synthetic templates greatly reduces the computational resources necessary for optimally determining structural features of the target peptide or protein. The present invention also provides methods for rapid and efficient analysis of the effect of mutations on target peptides and proteins.

Abstract: The present invention is an accelerated conformational sampling method for predicting target peptide and protein structures comprising a process of determining energy minimized synthetic templates using a simple system for modeling individual molecular bonds within the subject peptide or protein. Use of these synthetic templates greatly reduces the computational resources necessary for optimally determining structural features of the target peptide or protein. The present invention also provides methods for rapid and efficient analysis of the effect of mutations on target peptides and proteins.

Abstract: A computing network uses Time Division Multiplexing (TDM) to divide the time on a bus into a plurality of frames, each frame having a plurality of time slots. Each time slot is assigned no more than one of the plurality of devices within a collision domain, the assignments indicating the identity of the device permitted to transmit packets onto the network during the assigned time slot. A bus cadence unit simultaneously sends an epoch packet initiating the frame. The epoch packet contains a time slot assignment table containing the time slot assignments, the device identification, as well as a time slot offset and duration. Each device on the network is configured to measure a frame interval between repeating epoch packets. The measured frame interval is further processed in each receiving node to obtain a calibrated frame interval. The calibrated frame interval is used to accurately synchronize transmissions of data from the various devices onto the network.

Abstract: A computing network uses Time Division Multiplexing (TDM) to divide the time on a bus into a plurality of frames, each frame having a plurality of time slots. Each time slot is assigned no more than one of the plurality of devices within a collision domain, the assignments indicating the identity of the device permitted to transmit packets onto the network during the assigned time slot. A bus cadence unit simultaneously sends an epoch packet initiating the frame. The epoch packet contains a time slot assignment table containing the time slot assignments, the device identification, as well as a time slot offset and duration. Each device on the network is configured to measure a frame interval between repeating epoch packets. The measured frame interval is further processed in each receiving node to obtain a calibrated frame interval. The calibrated frame interval is used to accurately synchronize transmissions of data from the various devices onto the network.

Abstract: A method for preparing carbon materials having high surface area and high macropore volume to provide high permeability. These carbon materials are prepared by dissolving a carbonizable polymer precursor, in a solvent. The solution is cooled to form a gel. The solvent is extracted from the gel by employing a non-solvent for the polymer. The non-solvent is removed by critical point drying in CO.sub.2 at an elevated pressure and temperature or evaporation in a vacuum oven. The dried product is heated in an inert atmosphere in a first heating step to a first temperature and maintained there for a time sufficient to substantially cross-link the polymer material. The cross-linked polymer material is then carbonized in an inert atmosphere.

Abstract: A display system for use on a digital computer is specifically designed to display information about nucleotide sequences, such as DNA sequences and the protein or amino acid sequences associated with those nucleotide sequences. The system uses a specially adapted font which includes special three letter characters representing the amino acids. The letters in the special characters are kerned for compact presentation. The use of such three letter characters, created to be of a width three times that of the remaining monospace characters in the font, allows amino acid sequences to be stored and presented with the corresponding nucleotide sequences in such a fashion that they are properly aligned and also usually legible.

Abstract: A system and method for the construction of one-dimensional maps from fragmentation data is disclosed. Particularly useful for construction of restriction maps of DNA, the system and method completely permutes sites, single digest fragments, and any available multiple digest fragments, and displays maps in rank-order according to a quality factor. Display of constructed maps includes information about relative ordering of all fragments, sites, and particularly about closely-spaced sites and fragments.