Abstract: Equipotent indolocarbazole-derived analogs of staurosporine identified herein are prepared through C—H borylation chemistry. Functionality resides at C2 and C10 of the indolocarbazole aromatic region. Introducing functionality in this previously inaccessible region does not abrogate kinase activity and is shown to change the selectivity profile.

Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: Equipotent indolocarbazole-derived analogs of staurosporine identified herein are prepared through C—H borylation chemistry. Functionality resides at C2 and C10 of the indolocarbazole aromatic region. Introducing functionality in this previously inaccessible region does not abrogate kinase activity and is shown to change the selectivity profile.

Abstract: A multi-layered therapy pad is provided having a comfortable and supportive structure that houses heat therapy and electrotherapy means for treating back injuries and sores while an individual lies thereon. The pad comprises a first and second outermost layer of low-resilience polyurethane foam sandwiching an internal layer of higher density foam, which also supports electrical connections between the therapy controller, the power source, and the two therapy means within the pad. The electrotherapy means comprises static or tethered electrodes that apply pulsing electric current directly onto the user's back for stimulation and easing of back pain, while the heat therapy is applied using a resistance heating element within the pad, which heats a majority of the pad for applying heat to the user's back. The operation of the therapy means is controlled by an external controller, while power in received through an external source or an internal battery pack.

Abstract: A multi-layered therapy pad is provided having a comfortable and supportive structure that houses heat therapy and electrotherapy means for treating back injuries and sores while an individual lies thereon. The pad comprises a first and second outermost layer of low-resilience polyurethane foam sandwiching an internal layer of higher density foam, which also supports electrical connections between the therapy controller, the power source, and the two therapy means within the pad. The electrotherapy means comprises static or tethered electrodes that apply pulsing electric current directly onto the user's back for stimulation and easing of back pain, while the heat therapy is applied using a resistance heating element within the pad, which heats a majority of the pad for applying heat to the user's back. The operation of the therapy means is controlled by an external controller, while power in received through an external source or an internal battery pack.

Abstract: Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11) are prepared via ring expansion of the furanosylated congeners (e.g.

Abstract: A portable wheel assembly for use with bicycles and other wheeled vehicles. The wheel assembly comprises a centrally positioned hub which is adapted for rotatable movement about an axis. A plurality of pie shaped disk segments are coupled together along their radial side edges to form a circular support disk with a central opening. Each disk segment is adapted to removably couple with the hub at its innermost radial edge and extends radially outwardly to form a portion of a circular rim at its outermost radial edge. The rim is adapted for supporting a tire. The tire comprises a non-pneumatic tire with an annular ridge which is adapted to couple with the circular rim formed by the disk. During assembly, each of the pie shaped disk segments is coupled together and then coupled to the hub assembly at the inside radial edge or central opening. As the disk segments are coupled to the hub, the tire is assembled onto the outer radial edge or rim.

Abstract: A shared bus system having a bus and a set of client modules coupled to the bus. Each client module is capable of sending transactions on the bus to other client modules and receiving transactions on the bus from other client modules for processing. Each module has a queue for storing transactions received by the module for processing. A bus controller limits the types of transactions that can be sent on the bus to prevent any module's queue from overflowing.

Abstract: A shared bus system having a bus and a set of client modules coupled to the bus. Each client module is capable of sending transactions on the bus to other client modules and receiving transactions on the bus from other client modules for processing. Each module has a queue for storing transactions received by the module for processing. A bus controller limits the types of transactions that can be sent on the bus to prevent any module's queue from overflowing.

Abstract: Tertiary alcohols containing the structural features illustrated in 3 or 4 below (Scheme I) are prepared by reacting at least one diazo carbonyl compound, e.g., 1 in Scheme I) and at least one allylic alcohol (e.g., 2 in Scheme I) in a coupling reaction run under conditions that produce carbene or carbenoid intemediates from the diazo containing substrate such as transition metal catalysis or either thermal or photochemical decomposition. In some preferred embodiments, Rh.sub.2 (OAc).sub.4 is employed to catalyze the coupling reaction. ##STR1## Indolocarbazoles (e.g., 7 below) are prepared by coupling of diazo carbonyl compounds (e.g., 5) and biindoles (e.g., 6). Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g.

Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.

Abstract: A bus system having a bus arbitration scheme. The bus system includes a bus and a plurality of client modules coupled to the bus. Each of the client modules is capable of transmitting information on the bus to another of client module, and only one client module is entitled to transmit information on the bus at any time. A module entitled to transmit information on the bus has control of the bus for a minimum period of time defining a cycle. To determine which module is entitled to use the bus, each client module generates an arbitration signal when it seeks to transmit information on the bus. Each client module has an arbitration signal processor responsive to the arbitration signals for determining whether the module is entitled to transmit information on said bus. The system preferably also contains a host module that informs the client modules what types of transactions allowed on the bus in a given cycle.

Abstract: Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.

Abstract: Improvements to a skateboard comprise a board having a complete string of LED's embedded in a groove around the periphery of the skateboard in the first embodiment, powered by a microcontroller and a battery mounted to the underside of the board. In the second embodiment, along the same lines, a kit is provided wherein skid bars have the LED's mounted in them, connected by wiring leading to the microcontroller and battery. The kit can be sold for after-market use, and may consist of just the two side boards, or the rear skid board as well, often called the kick board.

Abstract: A portable rock drill rig includes a pair of telescoping struts for supporting and positioning a mast or feed beam. The struts are connected at their upper ends to a support bracket which is connected to an elongated mast support member by a hydraulic cylinder to provide relative sliding movement between the bracket and support member. The drill rig includes a crawler undercarriage having spaced apart and pivotally mounted crawler assemblies. The lower ends of the struts are each connected to an arm which is fixed to the main frame of the undercarriage. The arms are also connected to respective track oscillation cylinders. The mounting arrangement of the struts provides for improved positioning of the mast for drilling, tramming and transport operations.