Abstract: The present invention is directed to the tartrate salt of a FAK inhibitor defined by formula (I) below, and the use of that inhibitor for treating a proliferative disease.

Abstract: The present invention is directed to the tartrate salt of a FAK inhibitor defined by formula I below, and the use of that inhibitor for treating a proliferative disease:

Abstract: A forestry machine includes a ground propulsion apparatus, a chassis supported by the ground propulsion apparatus, a cab, an engine and a work implement. The chassis includes a front chassis portion and a rear chassis portion. The front chassis portion includes an upper portion and a lower portion. The rear chassis portion has a wood basket supported thereon. The cab is rotatably supported on the front chassis portion by a rotatable connection about a cab rotation axis to be selectively rotated 360 degrees. The engine is integrated into the front chassis portion. At least a part of the engine is disposed below an upper most surface of the upper portion. The work implement is movably attached to the cab. The work implement includes a boom movably attached to the cab, an arm movably attached to the boom, and a work tool attached to the arm.

Abstract: Hydraulic displacement mechanisms, and methods of using hydraulic displacement mechanisms to remove cables jammed or stuck in a conduit or other passageways, are disclosed.

Abstract: A method of treating or preventing pulmonary fibrosis in a patient in need thereof by administering a FAK inhibitor defined by formula I or a pharmaceutically acceptable derivative thereof to said patient: (I)

Abstract: A manhole guard, methods of assembling the same, and methods of using the same, are described. The manhole guard generally includes a plurality of sections connected for movement, the sections being capable of being locked into a fixed rigid structure through the use of a first arm and second arm that act independently of each other. The manhole guard may include a safety net attached to one or more sections of the manhole guard. The manhole guard may include attachable mounting brackets designed to facilitate the attachment of a first hoist device and/or first winch and include attachable mounting members designed to facilitate the attachment of a second hoist device and/or second winch.

Abstract: The present invention is directed to the tartrate salt of a FAK inhibitor defined by formula (I) below, and the use of that inhibitor for treating a proliferative disease.

Abstract: Potentially malicious uniform resource locators and websites are safely and effectively investigated through live forensic browsing. Live data from an isolated browser feeds a security information and event management (SIEM) tool and other forensic tools during a browsing session, allowing investigators to direct the browsing in response to analysis results. Session data may be translated for SIEM ingestion. Browsing sessions may be manually or automatically customized to obscure their forensic nature, by routing selection, by bandwidth or latency adjustment, or by spoofing externally detectable characteristics such as geolocation, user agent, time zone, and language. Forensic activity by an investigator may also be obscured from discovery by an attacker as a result of spoofing the browser's context, such as plugin status and host machine physical characteristics.

Abstract: A cut resistant knife, and a method for stripping jacket or sheathing off of a cable, are described.

Abstract: Methods by which an autonomous vehicle or related system may determine when a high definition (HD) map is out of date are disclosed. As the vehicle moves in an area, it captures sensor data representing perceived features of the area. A processor will input the sensor data along with HD map data for the area into a neural network to generate an embedding that identifies differences between features in the map data and corresponding features in the sensor data. The system may convert the sensor data into a birds-eye view or ego view before doing this. The network will identify any differences that exceed a threshold. The network will report the features for which the differences that exceed the threshold as features of the HD map that require updating.

Abstract: The disclosure generally relates to antibodies and antibody fragments that specifically bind human EpCAM, EpCAM activatable antibodies, and immunoconjugates thereof, as well as, methods of making and using the antibodies, antibody fragments, activatable antibodies, and immunoconjugates, for the diagnosis and treatment of diseases such as cancer.

Abstract: Potentially malicious uniform resource locators and websites are safely and effectively investigated through live forensic browsing. Live data from an isolated browser feeds a security information and event management (SIEM) tool and other forensic tools during a browsing session, allowing investigators to direct the browsing in response to analysis results. Session data may be translated for SIEM ingestion. Browsing sessions may be manually or automatically customized to obscure their forensic nature, by routing selection, by bandwidth or latency adjustment, or by spoofing externally detectable characteristics such as geolocation, user agent, time zone, and language. Forensic activity by an investigator may also be obscured from discovery by an attacker as a result of spoofing the browser's context, such as plugin status and host machine physical characteristics.

Abstract: A cut resistant knife, and a method for stripping jacket or sheathing off of a cable, are described.

Abstract: Hydraulic displacement mechanisms, and methods of using hydraulic displacement mechanisms to remove cables jammed or stuck in a conduit or other passageways, are disclosed.

Abstract: A forestry machine includes a ground propulsion apparatus, a chassis supported by the ground propulsion apparatus, a cab, an engine and a work implement. The chassis includes a front chassis portion and a rear chassis portion. The front chassis portion includes an upper portion and a lower portion. The rear chassis portion has a wood basket supported thereon. The cab is rotatably supported on the front chassis portion by a rotatable connection about a cab rotation axis to be selectively rotated 360 degrees. The engine is integrated into the front chassis portion. At least a part of the engine is disposed below an upper most surface of the upper portion. The work implement is movably attached to the cab. The work implement includes a boom movably attached to the cab, an arm movably attached to the boom, and a work tool attached to the arm.

Abstract: A manhole guard, methods of assembling the same, and methods of using the same, are described. The manhole guard generally includes a plurality of sections connected for movement, the sections being capable of being locked into a fixed rigid structure through the use of a first arm and second arm that act independently of each other. The manhole guard may include a safety net attached to one or more sections of the manhole guard. The manhole guard may include attachable mounting brackets designed to facilitate the attachment of a first hoist device and/or first winch and include attachable mounting members designed to facilitate the attachment of a second hoist device and/or second winch.

Abstract: A manhole guard, methods of assembling the same, and methods of using the same, are described. The manhole guard generally includes a plurality of sections connected for movement, the sections being capable of being locked into a fixed rigid structure through the use of a first arm and second arm that act independently of each other. The manhole guard can include attachable mounting brackets designed to facilitate the attachment of a hoist device and/or winch.

Abstract: Systems, methods, and apparatus for space surveillance are disclosed herein. In one or more embodiments, the disclosed method involves scanning, by at least one sensor on at least one satellite in super-geostationary earth orbit (super-GEO), a raster scan over a field of regard (FOR). In one or more embodiments, the scanning is at a variable rate, which is dependent upon a target dwell time for detecting a target of interest. In at least one embodiment, the target dwell time is a function of a characteristic brightness of the target.

Abstract: Systems, methods, and apparatus for space surveillance are disclosed herein. In one or more embodiments, the disclosed method involves scanning, by at least one sensor on at least one satellite in inclined super-geostationary earth orbit (super-GEO), a raster scan over a field of regard (FOR). In one or more embodiments, the scanning is at a variable rate, which is dependent upon a target dwell time for detecting a target of interest. In at least one embodiment, the target dwell time is a function of a range from at least one sensor to the target of interest and a function of a solar phase angle. In some embodiments, the axis of inclination of the inclined super-GEO is a function of the solar phase angle.

Abstract: Systems, methods, and apparatus for space surveillance are disclosed herein. In one or more embodiments, the disclosed method involves scanning, by at least one sensor on at least one satellite in inclined super-geostationary earth orbit (super-GEO), a raster scan over a field of regard (FOR). In one or more embodiments, the scanning is at a variable rate, which is dependent upon a target dwell time for detecting a target of interest. In at least one embodiment, the target dwell time is a function of a range from at least one sensor to the target of interest and a function of a solar phase angle. In some embodiments, the axis of inclination of the inclined super-GEO is a function of the solar phase angle.