Patents by Inventor John Lambourne

John Lambourne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Producing Genetically Modified Cells
    Publication number: 20250109413
    Abstract: The present disclosure relates to a new modular approach for the generation of genetically modified cells, particularly immune cells and iPSCs, enabling the simultaneous precise editing of defined nucleic acid targets (knock-out) and the introduction of an exogenous sequence of choice at a desired locus (knock-in) using a common Cas9 element.
    Type: Application
    Filed: August 5, 2022
    Publication date: April 3, 2025
    Applicants: Rutgers, The State University of New Jersey, Horizon Discovery Limited
    Inventors: Shengkan Jin, Juan-Carlos Collantes, John Lambourne, Immacolata Porreca, Tommaso Selmi
  • METHOD FOR PRODUCING GENETICALLY MODIFIED CELLS
    Publication number: 20240067954
    Abstract: The present invention relates to an RNA-mediated base editing system that enables recruitment of multiple effector proteins to a single target site, allowing for highly efficient base editing. The invention further relates to methods and kits for genetically modifying a cell.
    Type: Application
    Filed: January 5, 2022
    Publication date: February 29, 2024
    Inventors: John Lambourne, Immacolata Porreca, Amanda Smith
  • METHOD FOR PRODUCING GENETICALLY MODIFIED CELLS
    Publication number: 20230235315
    Abstract: A method for producing genetically engineered immune cells, e.g. T cells, or iPSCs which uses an RNA-scaffold mediated base editing system. The method enables precise modifications to be made to the genome whilst minimizing the possibility of off-target effects, making the method particularly suitable for therapeutic applications.
    Type: Application
    Filed: July 9, 2021
    Publication date: July 27, 2023
    Inventors: John Lambourne, Immacolata Porreca