Abstract: The present disclosure provides SETD2 protein inhibitors, and methods, compositions, and kits for treating diseases, disorders, or conditions in a subject with a SETD2 protein inhibitor and, optionally, a second therapeutic agent, wherein the second therapeutic agent comprises one or more glucocorticoid receptor agonists, one or more immunomodulatory drugs, one or more proteasome inhibitors, one or more Bcl-2 inhibitors, one or more pleiotropic pathway modulators, one or more XPO1 inhibitors, one or more histone deacetylase inhibitors, or one or more EZH2 inhibitors, or a combination thereof.

Abstract: The present disclosure provides substituted indole compounds of Formula I: (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1e, G1, G2, Q1, Q2, Q3, and (II) are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disease, disorder, or condition such as cancer in a subject.

Abstract: The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

Abstract: This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.

Abstract: This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.

Abstract: An apparatus includes an outer rectangular tube and an inner rectangular tube. The inner rectangular tube and the outer rectangular tube are movable in relation to each other. In some versions a gas spring is positioned within the outer rectangular tube and the inner rectangular tube. In some versions, the apparatus further comprises a pair of inner bearing blocks operable to change the coefficient of friction between the inner rectangular tube and the outer rectangular tube. In some versions, the apparatus further comprises an outer bearing block assembly operable to change the coefficient of friction between the outer bearing block assembly and the inner rectangular tube.

Abstract: An apparatus includes an outer rectangular tube and an inner rectangular tube. The inner rectangular tube and the outer rectangular tube are movable in relation to each other. In some versions a gas spring is positioned within the outer rectangular tube and the inner rectangular tube. In some versions, the apparatus further comprises a pair of inner bearing blocks operable to change the coefficient of friction between the inner rectangular tube and the outer rectangular tube. In some versions, the apparatus further comprises an outer bearing block assembly operable to change the coefficient of friction between the outer bearing block assembly and the inner rectangular tube.

Abstract: Perforating a biological membrane by (i) obtaining a medical device having a longitudinally elongated shaft and a blunt tipped contact face disposed at the longitudinal distal end of the shaft, and (ii) concurrently pressing the contact face against a biological membrane and rotating the shaft about the longitudinal axis so as to effect rotation of the contact face and the biological membrane about a longitudinal centerpoint on the contact face until the membrane is perforated.

Abstract: The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.

Abstract: A device for organizing slack in a flexible line comprising a unitary element with clips formed in the top and bottom of the element for releasably retaining a flexible line at a point intermediate the ends of the line in the absence of an inwardly pinching bias. The device preferably has a saddle curved first major surface.

Abstract: In one embodiment, a display comprising: a sleeve having a first guide; a movable member that moves in relation to the sleeve, the movable member having a second guide; and a slider slidably secured to the first guide and slidably secured to the second guide; whereby movement of the member causes the first guide and the second guide to cooperate in directing movement of the slider. In another embodiment, a display comprising: a sheet having a front side and a back side; a rotatable member positioned on the front side of the sheet; a wheel positioned on the back side of the sheet; a shaft extending through the sheet, the shaft joining the rotatable member to the wheel; and a member slidable in relation to the sheet and to the wheel, the member having a surface for contacting the wheel and causing the wheel and the rotatable member to rotate when the member slides.

Abstract: The invention is a method of supporting tools and supplies atop a sloped roof. The method includes (a) obtaining a caddy with a base and a shelf pivotally connected to one another, (b) placing the base of the caddy into supportive contact with a sloped roof, (c) pivoting the shelf of the caddy relative to the base about a laterally extending axis until the shelf is substantially horizontal, (d) supporting the shelf at the substantially horizontal position with a support member, and (e) placing a plurality of individual tools or supplies upon the substantially horizontal shelf.

Abstract: The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.

Abstract: A bandage with (i) a supple backing layer having first and second major surfaces, and (ii) a longitudinally elongated elastic splint adhesively secured to the first major surface of the backing.

Abstract: The invention takes the form of various embodiments including: first, a receptacle for a beverage container with a temperature gauge affixed to the receptacle that takes and displays a temperature reading of the container in the receptacle; second, a receptacle for receiving a beverage container with a gauge affixed to the receptacle that registers movement of the beverage container within the receptacle; third, a receptacle for receiving a beverage container with an electrically powered device attached to the receptacle; and, fourth, a receptacle for receiving a beverage container with a gauge affixed to the receptacle that indicates whether the receptacle is level with a plane.

Abstract: A medical device, comprising (i) a longitudinally elongated shaft with a contact face disposed at one end of the shaft effective for perforating a biological membrane when the contact face is pressed against the biological membrane and rotated about the longitudinal axis.

Abstract: A door hanging assembly for hanging on a sectional garage door. The door hanging assembly includes a hung object with a top end and a bottom end and at least one hook configured and arranged for hanging the top end of the hung object on the top edge of the top section of the garage door. The door hanging assembly can further include at least one stabilizer affixed to the bottom end of the hung object to maintain the bottom end of the hung object between the top edge and the bottom edge of one section when the garage door opens and closes.

Abstract: Protective headguard comprising a protective pad and a retention element cooperatively attached to the protective pad wherein the headguard defines at least two separate and distinct, diametrically intersecting and inwardly influenced circumferential lines of retention when worn on the head.