Abstract: Piercing probes for fluidic applications may include a body portion including a distal end of the piercing probe. The piercing probes may also include a piercing portion opposite the distal end of the piercing probe. The piercing portion may include a conical portion, which may include a piercing tip. The piercing probe may also include a continuous lumen defined through the body portion and the piercing portion. The continuous lumen may be centered about a primary longitudinal axis of the piercing probe. A longitudinal tip axis may be defined through the piercing tip parallel to the primary longitudinal axis. The longitudinal tip axis may be offset from the primary longitudinal axis by an offset distance greater than zero. Fluid-sampling systems including the piercing probes may further include a device configured to draw or expel fluid through the continuous lumen.