Abstract: The disclosure provides methods of using certain morphinans of Formula (I) that are partial kappa opioid receptor agonists, weak mu opioid receptor agonists, and partial or weak delta opioid receptor agonists in the treatment of kappa opioid receptor-associated diseases and conditions. The disclosure provides methods of treating pruritus, acute seizures, and seizure disorders. The disclosure also provides a method of treating cocaine addiction by administering a particular compound of Formula I, PPL-103, to a cocaine addicted patient.

Abstract: Some aspects of the present disclosure relate to systems and processes for the conversion of lithium phosphate into a low-phosphate solution containing lithium which may be suitable as feedstock for the production of saleable lithium products.

Abstract: There is provided a method of manufacturing a nutritional composition comprising carbohydrate in an amount of at least 250 g l?1 of composition. The method comprises the steps of: (i) combining a first gelling agent and water; (ii) heating the mixture produced in step (i) to a temperature of between 60° C. and 100° C.; (iii) combining a second gelling agent with the heated mixture of step (ii) with mixing; and (iv) maintaining the mixture produced in step (iii) at a temperature of between 70° C. and 100° C. for between 10 and 120 minutes; with a carbohydrate component being combined with the mixture during one or more of said steps. Also provided is a nutritional composition.

Abstract: Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

Abstract: A display apparatus 10 and a support arrangement 16 and flexible display member 14. A support arrangement 16 includes an elongate support member 44 with an upper transverse member 54 at its upper end, and urge resiliently upwardly therefrom. A lower transverse member 48 is provided the lower end of the elongate support member 44. The upward resilient urging of the upper transverse members 54 applies tension to a display member extending between the lower and upper transverse members 48, 54.

Abstract: Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

Abstract: A display apparatus 10 and a support arrangement 16 and flexible display member 14. A support arrangement 16 includes an elongate support member 44 with an upper transverse member 54 at its upper end, and urge resiliently upwardly therefrom. A lower transverse member 48 is provided the lower end of the elongate support member 44. The upward resilient urging of the upper transverse members 54 applies tension to a display member extending between the lower and upper transverse members 48, 54.

Abstract: A customizable modular storage unit organizer apparatus with a pair of slides, a pair of slide covers, a pair of cross bars, a pair of retainer clips, and a container for storing articles within the apparatus. The cross bars extend between, are affixed to the slide covers, and have two distal ends, top, bottom, first and second side portions, a slot extending longitudinally along the length of the exterior surface of cross bars for accommodating attachments. The retainer clips allow the slide covers to be selectively, repeatedly, and releasably retained to the slides. The size of the enclosure formed between the slide covers and cross bars may be modified by adjusting the positions of the cross bars on the slide covers.

Abstract: A connection assembly 10 usable for interconnecting two elongate frame members 12 which each include a channel 14. An elongate link member 22 is locatable in the channels 14 of the adjacent members 12 and extending therebetween. A respective connection assembly 20 is locatable in each of the channels 14 to engage against the link member 22 and retain same in the respective channel 14. Each connection assembly 20 is selectively movable between an engaged and a disengaged condition to respectively connect the two frame members 12, or permit the frame members 12 to be pulled apart.

Abstract: A base made of a composite material supports a generator assembly. The base may support a number of components of the generator assembly, including an alternator, an engine, a control panel, a fuel tank, and a lifting frame. The base may include first and second tiers that are in two different horizontal planes for mounting of the alternator on one tier and the engine on the second tier, with a drive shaft of the alternator being aligned with a drive shaft of the engine. The base may include ribs extending from an under side of a support surface of the base in order to distribute loads and withstand stresses that result from the weight of the generator assembly.

Abstract: There is provided a method of manufacturing a nutritional composition comprising carbohydrate in an amount or at least 250 g l?1 of composition. The method comprises the steps of: (i) combining a first gelling agent and water; (ii) heating the mixture produced in step (i) to a temperature of between 60° C. and 100° C.; (iii) combining a second gelling agent with the heated mixture of step (ii) with mixing and (iv) maintaining the mixture produce in step (iii) at a temperature of between 70° C. and 100° C. for between 10 and 120 minutes; with a carbohydrate component being combined with the mixture during one or more of said steps. Also provided is a nutritional composition.

Abstract: A gate valve assembly having a through bore adapted for fluid communication with a well bore and prepared for receiving an elongated member. The gate valve assembly comprises a gate element which is movably arranged in a gate valve housing, wherein the gate element has a gate bore arranged for receiving the elongated member, wherein a cutting tool is arranged in the gate bore first and second seats, wherein at least one of the first or second seat is arranged to provide sealing contact with a sealing surface of the gate element.

Abstract: A connection assembly 10 usable for interconnecting two elongate frame members 12 which each include a channel 14. An elongate link member 22 is locatable in the channels 14 of the adjacent members 12 and extending therebetween. A respective connection assembly 20 is locatable in each of the channels 14 to engage against the link member 22 and retain same in the respective channel 14. Each connection assembly 20 is selectively movable between an engaged and a disengaged condition to respectively connect the two frame members 12, or permit the frame members 12 to be pulled apart.

Abstract: The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules.

Abstract: A generator assembly may include a base made of a composite material for supporting a plurality of components including an alternator, and engine, and a fuel tank for storing the fuel for the operation of the engine. The base may include a recess formed in a support surface of the base, and a lid configured to be detachably mounted to the support surface to close the recess and form the fuel tank. The lid may include a baffle configured to extend into the recess and separate and define a fuel feed chamber and a return flow chamber in the recess.

Abstract: A base made of composite material is configured for supporting a generator. The base may experience some vibrations transferred from the generator. The base may include one or more mounting members to secure the generator to the base. The mounting members are located at least partially over each of a plurality of access pockets provided in the base. The mounting members are arranged over the access pockets to provide an access to the underneath of the mounting member.

Abstract: A customizable modular storage unit organizer apparatus with a pair of slides, a pair of slide covers, a pair of cross bars, a pair of retainer clips, and a container for storing articles within the apparatus. The cross bars extend between, are affixed to the slide covers, and have two distal ends, top, bottom, first and second side portions, a slot extending longitudinally along the length of the exterior surface of cross bars for accommodating attachments. The retainer clips allow the slide covers to be selectively, repeatedly, and releasably retained to the slides. The size of the enclosure formed between the slide covers and cross bars may be modified by adjusting the positions of the cross bars on the slide covers.

Abstract: A base made of a composite material supports a generator assembly. The base may support a number of components of the generator assembly, including an alternator, an engine, a control panel, a fuel tank, and a lifting frame. The base may include first and second tiers that are in two different horizontal planes for mounting of the alternator on one tier and the engine on the second tier, with a drive shaft of the alternator being aligned with a drive shaft of the engine. The base may include ribs extending from an under side of a support surface of the base in order to distribute loads and withstand stresses that result from the weight of the generator assembly.

Abstract: Compounds of Formula (I) are disclosed. The variables R1-R11 are described herein. Certain compounds of Formula (I) are partial agonists of the mu, delta, and kappa opioid receptors, and are useful for treating pain and opioid addiction, with fewer side effects than conventional opioids. Methods for preparing the disclosed compounds, pharmaceutical compositions containing compounds of Formula (I), and methods of treating pain and opioid addiction in patients are also disclosed.