Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A laser system for creating patterns on clothing includes a laser source; a phased array acousto-optic deflector (AOD) configured to control the direction and intensity of the laser beam; a computer comprising software for reading input files containing pattern designs and controlling the AOD to direct the laser beam according to the pattern designs; a fabric preparation station for washing and preparing fabric before laser treatment; a post-laser wash station for removing debris from the fabric after laser treatment; and a clothing finishing station for applying finishing touches to the fabric. The AOD includes an optical element having a surface with one or more steps formed thereon; a conductive layer formed on the surface with the steps; one or more crystals secured to each step; and electrodes positioned on each surface of each crystal.

Abstract: A tunable filter for microscope includes an optical element having a surface with one or more steps formed thereon; a conductive layer formed on the surface with the steps; one or more crystals secured to each step; and electrodes positioned on each surface of each crystal.

Abstract: An acousto-optic deflector includes an optical element having a surface with one or more steps formed thereon; a conductive layer formed on the surface with the steps; one or more crystals secured to each step; and electrodes positioned on each surface of each crystal.

Abstract: Equipment for forming a tubular rod of fibrous material comprises: a gathering station constructed to receive a continuous supply of fibres and to gather the fibres into a bundle as the fibres advance through the equipment; a divider arranged in the path of the fibres through the equipment and constructed to from a cleft along the length of the bundle as it advances through the equipment; a mandrel positioned in the path of the bundle of fibres in alignment with the divider and constructed to form the cleft into a passage through the bundle of fibres as the bundle of fibres advances over the mandrel; and a die constructed and arranged to cooperate with the mandrel to form the fibres in a tubular configuration around the mandrel.

Abstract: Far field devices typically rely on audio only for enabling user interaction and involve only audio processing. Adding a vision-based modality can greatly improve the user interface of far field devices to make them more natural to the user. For instance, users can look at the device to interact with it rather than having to repeatedly utter a wakeword. Vision can also be used to assist audio processing, such as to improve the beamformer. For instance, vision can be used for direction of arrival estimation. Combining vision and audio can greatly enhance the user interface and performance of far field devices.

Abstract: A system is disclosed. The system includes a first circuit that includes a first receiver configured to receive a wireless power input, a first conductor, and operably coupled to the first receiver, and a switch network operably coupled to the first conductor configured to rectify the wireless power input and generate a rectified voltage. The first circuit further includes a first field effect transistor operably coupled to the first conductor and configured to receive a portion of the wireless power input from the first conductor and output an output voltage back to the first conductor based upon a gate input.

Abstract: The technology described herein is directed to methods of determining oligonucleotide sequences, e.g. by enriching target sequences prior to sequencing the sequences.

Abstract: Described herein are various embodiments of methods for binding together textured substrates using mycelium-producing fungi. The method can generally include providing a textured substrate, such as a textured protein substrate, that may or may not be subjected to various pre-processing steps used to help promote mycelium growth inside, outside or inside and outside of the textured substrate, inoculating the textured substrate with mycelium-producing fungi, and growing mycelium inside, outside, or inside and outside of the textured substrate to bind the textured substrate. The bound textured substrate can be used as a high protein food, such as meat substitutes, meat analogues, or seafood analogues. In some embodiments, the mycelium-producing fungi is used to bind together multiple textured substrates to form larger composite food products.

Abstract: Systems and methods are disclosed to perform isotope identification by applying an acoustic wave to an acousto-optic device to induce a frequency shift in the optical beam; adjusting the frequency of the acoustic wave to match the energy level transition of an isotope; exciting the isotope to a higher energy level through absorption of the frequency-shifted optical beam; and detecting the resulting energy level transition of the isotope.

Abstract: A wireless power transfer device may include a circuit couplable with a coil to transmit or receive a first signal providing wireless power through the coil. The first signal may be modulated with second signals. A packet within any of the second signals may include first bits associated with a preamble and second bits associated with data. The device may further include a controller to measure temporal variations of at least one of the first signal, a rectified version of the first signal, or the one or more second signals. The controller may further determine thresholds for distinguishing between bits in the packet based on the temporal variations. The device may further demodulate the signals using the one or more thresholds to identify the preamble of the packet and extract the second bits associated with data from the packet when the preamble of the packet is identified.

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: A content generation platform is generally described herein. More specifically, interactive image generation and techniques and features thereof are disclosed herein. One or more sets of images of a scene are captured in an imaging studio. The captured one or more sets of images of the scene are processed using one or more machine learning based networks to generate an interactive image of the scene comprising a plurality of interactive features. One or more of the plurality of interactive features of the generated interactive image may be modified or edited according to user preferences.

Abstract: A content generation platform is generally described herein. More specifically, interactive image generation and techniques and features thereof are disclosed herein. One or more sets of images of a scene are captured in an imaging studio. The captured one or more sets of images of the scene are processed using one or more machine learning based networks to generate an interactive image of the scene comprising a plurality of interactive features. One or more of the plurality of interactive features of the generated interactive image may be modified or edited according to user preferences.

Abstract: A content generation platform is generally described herein. More specifically, interactive image generation and techniques and features thereof are disclosed herein. One or more sets of images of a scene are captured in an imaging studio. The captured one or more sets of images of the scene are processed using one or more machine learning based networks to generate an interactive image of the scene comprising a plurality of interactive features. One or more of the plurality of interactive features of the generated interactive image may be modified or edited according to user preferences.

Abstract: A content generation platform is generally described herein. More specifically, interactive image generation and techniques and features thereof are disclosed herein. One or more sets of images of a scene are captured in an imaging studio. The captured one or more sets of images of the scene are processed using one or more machine learning based networks to generate an interactive image of the scene comprising a plurality of interactive features. One or more of the plurality of interactive features of the generated interactive image may be modified or edited according to user preferences.

Abstract: Systems and methods of adaptive workflow definition of crowd sourced tasks and quality control mechanisms for multiple business applications are disclosed. In one aspect, embodiments of the present disclosure include a method, which may be implemented on a system, for generating and distributing tasks to workers to optimize product categorization in an online marketplace, generating and distributing tasks to workers for search engine optimization of a website, and/or generating and distributing tasks to workers for business data verification and enhancement. Results can be aggregated from multiple workers to enhance or improve site information, site organization, or other business information to improve site placement in search results and/or to enhance/improve user experience.

Abstract: A lubricated rotational connection system provided with a free-wheel having a driving part and a driven part as well as at least one rotational link member arranged in a linking space, the linking space being located radially between a driving linking section and a driven linking section. A lubrication device comprises a fluid circulation device constrained to rotate with a driven pumping section of the driven part. The fluid circulation device is set in rotation with respect to a driving pumping section when the driving speed of rotation of the driving pumping section is lower than the driven speed of rotation of the driven pumping section about the axis of rotation in order to generate a forced circulation of the lubricating fluid within the linking space.

Abstract: A magnetic device for capturing metal wear particles in suspension in a lubrication fluid, the magnetic device being for inserting in a straight-line insertion direction of the magnetic device into a wall of a casing via a through orifice serving to put an inside volume of the casing containing the lubrication fluid into communication with an outside volume outside the casing, the magnetic device presenting a longitudinal axis X, the longitudinal axis X being for putting into coincidence with the direction for inserting the magnetic device into the casing, the magnetic device comprising a permanent magnet suitable for attracting the metal particles and a presence-detector member for detecting the metal particles attracted by the permanent magnet.