Abstract: Embodiments of the disclosure include methods and compositions related to treating or reducing the severity or delaying the onset of one or more cardiac conditions in a mammal In particular embodiments, the compositions concern Park2 and its use for a cardiac medical condition. In specific cases, effective amounts of Park2 polynucleotide(s) and/or Park2 polypeptide(s) are provided to an individual in need thereof, including for heart failure, for example. The administration may be locally to the heart, for example.

Abstract: A system for analysis and transaction processing includes an interface and a processor. The interface is configured to receive a task. The processor is configured to determine a processing estimate associated with the task by determining required resources for a set of possible processing solutions to perform the task and to determine a task engine based at least in part on the processing estimate. The task engine comprises an analysis engine or a transaction engine. The analysis engine or the transaction engine is used to process the task. The processor is further to provide the task to the task engine.

Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.

Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: A system for analysis and transaction processing includes an interface and a processor. The interface is configured to receive a task. The processor is configured to determine a processing estimate associated with the task by determining required resources for a set of possible processing solutions to perform the task and to determine a task engine based at least in part on the processing estimate. The task engine comprises an analysis engine or a transaction engine. The analysis engine or the transaction engine is used to process the task. The processor is further to provide the task to the task engine.

Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: A system for executing a plurality of transactions comprises a first processor and a memory. The first processor is configured to execute a first transaction comprising: providing a plurality of indications to make a plurality of first changes to a plurality of first records of a database; and committing the first transaction by updating the status of the first transaction in a transaction table while not providing an indication to update the status of the first records from pending. The memory is coupled to the first processor and configured to store the transaction table.

Abstract: In one embodiment, a method includes managing and controlling a plurality of data-access credentials. The method further includes accessing data from a plurality, of sources in a plurality of data formats. The accessing includes using one or more data-access credentials of the plurality of data-access credentials. The one or more data-access credentials are associated with at least a portion of the plurality of data sources. The method also includes abstracting the data into a standardized format for further analysis. The abstracting includes selecting the standardized format based on a type of the data. In addition, the method includes applying a security policy to the data. The applying includes identifying at least a portion of the data for exclusion from storage based on the security policy. Additionally, the method includes filtering from storage any data identified for exclusion. Further, the method includes storing the data in the standardized format.

Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: A system for executing a plurality of transactions comprises a first processor and a memory. The first processor is configured to execute a first transaction comprising: providing a plurality of indications to make a plurality of first changes to a plurality of first records of a database; and committing the first transaction by updating the status of the first transaction in a transaction table while not providing an indication to update the status of the first records from pending. The memory is coupled to the first processor and configured to store the transaction table.

Abstract: Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Abstract: In one embodiment, a method includes managing and controlling a plurality of data-access credentials. The method further includes accessing data from a plurality of sources in a plurality of data formats. The accessing includes using one or more data-access credentials of the plurality of data-access credentials. The one or more data-access credentials are associated with at least a portion of the plurality of data sources. The method also includes abstracting the data into a standardized format for further analysis. The abstracting includes selecting the standardized format based on a type of the data. In addition, the method includes applying a security policy to the data. The applying includes identifying at least a portion of the data for exclusion from storage based on the security policy. Additionally, the method includes filtering from storage any data identified for exclusion. Further, the method includes storing the data in the standardized format.

Abstract: A weed or insect terminating device features a container having a valve port, a heating element, a valve core, and a biasing mechanism forcing the valve core into an extended position. An axial passage in the valve core extends through only a distal end of the valve core. A lateral passage intersects the axial passage and opens radially from the valve core. A proximal seal is provided between the valve core and valve port at a location between a proximal end of the valve core and the opening of the lateral passage. The proximal seal withdraws from sealed contact with the port in a retracted state of the valve core, while a distal seal remains intact. Heated water from the container can be dispensed through the valve port only via the lateral and axial passages of the valve core, and only when made accessible by retraction of the valve core.

Abstract: The present invention is directed to methods and compositions that provide therapy for at least one medical condition that directly or indirectly affects cardiac muscle cells (also known as cardiomyocytes) in a mammalian individual, including humans, dogs, cats, horse pigs, and so forth. The medical condition may be of any kind, including a cardiac condition such as heart failure, cardiomyopathy, myocardial infarction, and so forth. The medical condition may have a cardiac condition as its primary symptom or cause or it may be a secondary symptom or cause. The individual may be male or female and may be of any age.

Abstract: Devices and methods for mobility assistance are disclosed. The disclosed features may assist a person with movement by providing support for the person as the person moves. Further, features for easily storing and transporting items in various compartments of the device are disclosed. Support of the user and/or items may be provided by a lightweight composite structure that further allows for free movement of the user, such as taking full strides while walking or running. The device may further be repeatedly configured between collapsed and deployed configurations via a locking mechanism and an actuatable release. Pivotable joints allow the various sections to be stowed into a smaller, collapsed configuration that is easily carried or otherwise transported, as well as deployed into a larger, deployed configuration for assistance while moving.

Abstract: In one embodiment, a method includes providing an a priori classification engine, an a posteriori classification engine, and a heuristics engine. The a priori classification engine is operable to perform an a priori classification. The a posteriori classification engine is operable to perform an a posteriori classification. The heuristics engine is operable to perform a heuristics classification. In addition, the method includes accessing data from at least one source. The method further includes, responsive to an indication that the a priori classification should be performed, performing the a priori classification on the data. The method also includes, responsive to an indication that the a posteriori classification should be performed, performing the a posteriori classification on the data. Further, the method includes, responsive to an indication that the heuristics classification should be performed, performing the heuristics classification on the data.

Abstract: Methods and information handling systems for managing at least one of storage of data to or access to data from a plurality of cloud storage drives coupled to user devices over a network. An information handling system includes a processing device and a memory that stores one or more program modules executable by the processing device to receive a request to store data from a user device, the request may lack information pertaining to where to store the data, to determine which of the cloud drives of the plurality of cloud drives will store the data in and to save the data to the cloud drive based on the determination.

Abstract: The present invention is directed to methods and compositions that provide therapy for at least one medical condition that directly or indirectly affects cardiac muscle cells (also known as cardiomyocytes) in a mammalian individual, including humans, dogs, cats, horse pigs, and so forth. The medical condition may be of any kind, including a cardiac condition such as heart failure, cardiomyopathy, myocardial infarction, and so forth. The medical condition may have a cardiac condition as its primary symptom or cause or it may be a secondary symptom or cause. The individual may be male or female and may be of any age.

Abstract: In one embodiment, a method includes maintaining, by a computer system, a plurality of data and at least one classification for each of the plurality of data. Each data of the plurality of data is aggregated from a plurality data sources and is abstracted into one or more of a plurality of standardized formats based on a type of the data. The computer system has executing thereon a plurality of classification engines. The plurality of classification engines include an a priori classification engine, an a posteriori classification engine, and a heuristics engine. Each at least one classification is generated by one of the plurality of classification engines. In addition, the method includes receiving query input from a user. Further, the method includes querying at least a portion of the plurality of data responsive to the query input.

Abstract: In one embodiment, a method includes maintaining, by a computer system, a plurality of data and at least one classification for each of the plurality of data. Each data of the plurality of data is aggregated from a plurality data sources and is abstracted into one or more of a plurality of standardized formats based on a type of the data. The computer system has executing thereon a plurality of classification engines. The plurality of classification engines include an a priori classification engine, an a posteriori classification engine, and a heuristics engine. Each at least one classification is generated by one of the plurality of classification engines. In addition, the method includes receiving query input from a user. Further, the method includes querying at least a portion of the plurality of data responsive to the query input.