Abstract: Described is a method for vacuum degassing of a liquid such as a solvent for a liquid chromatography system. The method includes modulating application of a vacuum to a fluid channel of a degasser so that each volume of a liquid drawn from the degasser experiences a residence time that is equal to the residence times of the other volumes. The residence time is determined as a time that the volume resides in the fluid channel under application of the vacuum and to a magnitude of the applied vacuum. The method is advantageous for use with liquid chromatography systems where differences in the diffusion rates of solvents into the degasser vacuum can otherwise introduce error into the composition gradient of a mobile phase.

Abstract: A fluidic coupler assembly (10) for use in a light-guided flow cell comprises a coupler body (12) having a sealing face (10a), a tubular insert such as an optical fiber (16) passing through a through bore (14) of the coupler body and through a ferrule (18) located adjacent the sealing face of the coupler body. A backing plug (20) holds the ferrule in position within the coupler body.

Abstract: Described is a method for vacuum degassing of a liquid such as a solvent for a liquid chromatography system. The method includes modulating application of a vacuum to a fluid channel of a degasser so that each volume of a liquid drawn from the degasser experiences a residence time that is equal to the residence times of the other volumes. The residence time is determined as a time that the volume resides in the fluid channel under application of the vacuum and to a magnitude of the applied vacuum. The method is advantageous for use with liquid chromatography systems where differences in the diffusion rates of solvents into the degasser vacuum can otherwise introduce error into the composition gradient of a mobile phase.

Abstract: The present invention relates to a device having an optical fiber coupled to a high pressure containment vessel and a method for making the same. The high pressure containment vessel can be an optical fiber based flow cell for a chromatography system.

Abstract: A fluidic coupler assembly (10) for use in a light-guided flow cell comprises a coupler body (12) having a sealing face (10a), a tubular insert such as an optical fibre (16) passing through a through bore (14) of the coupler body and through a ferrule (18) located adjacent the sealing face of the coupler body. A backing plug (20) holds the ferrule in position within the coupler body.

Abstract: The present invention relates to a device having an optical fiber coupled to a high pressure containment vessel and a method for making the same. The high pressure containment vessel can be an optical fiber based flow cell for a chromatography system.

Abstract: The present invention relates to apparatus and devices (11) for placing light with samples for analysis and method of making and using such apparatus and device.

Abstract: The present invention relates to apparatus and devices (11) for placing light with samples for analysis and method of making and using such apparatus and device.

Abstract: A peristaltic pump has a rotor supported on a frame that is removable in a radial direction with respect to the axis of rotation of the rotor. The rotor is retained in place on the frame by gravity and the forces applied by the opposing pump components.