Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

Abstract: In some embodiments, a showerhead assembly includes a heated showerhead having a heater plate and a gas distribution plate coupled together; an ion filter spaced from the heated showerhead; a spacer ring in contact between the heated showerhead and the ion filter; a remote plasma region between the heated showerhead and the ion filter; an upper isolator spaced from the spacer ring and supported on the ion filter; a sealing ring fastened to the heated showerhead sealing against the upper isolator and pushing the upper isolator against the ion filter; a gap between a bottom of the gas distribution plate and a top of the ion filter, the gap being in fluid communication with the remote plasma region; a first passage extending through the heater plate; and a second passage in communication with the first passage and extending through the gas distribution plate, the second passage extending to the gap.

Abstract: A method for controlling autonomous movement by a robot module is provided, including: generating a plurality of waypoints by a global planner; generating a plurality of velocities by a local planner, said velocities being configured to navigate the robot module through said waypoints; applying the velocities to control movement of the robot module.

Abstract: A method for autonomous navigation by a robot module is provided, including: receiving selection of a region of a map for coverage by the robot module; responsive to receiving the selection, then generating a path for traversal by the robot module, the path including one or more back-and-forth raster patterns that enable coverage of the region by the robot module; generating a plurality of waypoints along the path, the waypoints defining a sequence of target destinations for the robot module; autonomously moving the robot module through the waypoints in sequence, wherein moving the robot module through the waypoints causes the robot module to substantially traverse the path.

Abstract: A method is provided for generating a two-dimensional map for autonomous navigation by a robot module, including: using sensors of the robot module to sense a local environment and generate a three-dimensional model of the local environment; determining a level of ground throughout the three-dimensional model; setting a minimum height and a maximum height throughout the three-dimensional model, the minimum height being at a first predefined amount above the level of ground, and the maximum height being at a second predefined amount above the level of ground; generating a two-dimensional map by excluding objects from the three-dimensional model that are below the minimum height or above the maximum height, and setting a height of remaining objects to a same height; using the two-dimensional map by the robot module to autonomously navigate the local environment.

Abstract: The present disclosure provides a method of reversing ticagrelor-associated bleeding in a patient by administering an antibody or fragment thereof that binds to ticagrelor.

Abstract: A method for mapping functions of a brain includes receiving an MRI data set for a subject comprising fMRI data acquired with the subject lying in MRI scanning equipment in a state of rest, generating a voxel-wise correlation map that identifies, for each of a plurality of voxels of the brain, a measure of the degree of time correlation between spontaneous brain activations at one voxel of the brain as revealed in the resting-state fMRI data and spontaneous brain activations at each of the other voxels of the plurality of bran voxels as revealed in the resting-state fMRI data. The voxel-wise correlation map is input to a trained 3D convolutional neural network based machine learning algorithm to generate a functional connectivity map identifying a location where a predefined brain function is performed within the subject's brain by identifying the voxels involved in performing that predefined brain function.

Abstract: A Captioned Telephone Service (“CTS”) system, equipped with a CTS application, offers several user interfaces. These interfaces are designed to set the primary and secondary languages of the user, as well as the caption language of a contact. This configuration ensures that the caption language of a phone call matches the caption language assigned to the contact if the call is made with that contact. Additionally, if the caption language during a phone call is found to be incorrect, the system allows for a swift change to another language. This could be either the primary or secondary language of the user, or a completely different language, as required during the call.

Abstract: The present disclosure provides bifunctional compounds represented by Formula (I) as IRAK4 degraders via ubiquitin proteasome pathway, and methods for treating diseases modulated by IRAK4:

Abstract: The present disclosure relates to the field of medicine. More particularly, the disclosure is in the field of treatment of diabetes, obesity and/or chronic weight management, dyslipidemia and/or NASH. The disclosure relates to compounds that agonize the amylin receptor and can lower food intake, body weight, glucose and/or triglycerides, so can be used to treat diabetes, obesity, and/or dyslipidemia. The present disclosure also includes pharmaceutical compositions containing such compounds and therapeutic uses of such compounds and compositions.

Abstract: Systems and methods are disclosed herein for performing a milling operation within a wellbore in an oil-and-gas setting. An example system can include a milling tool, which can include a cutting head, a linear actuator configured to advance the cutting head, and a linear displacement measurement sensor associated with the linear actuator. The sensor can be configured to measure linear displacement of the linear actuator. The system can also include a cable to lower the milling tool, a control unit that receives data from the sensor, and a display device that displays a visualization of the data from the sensor. The control unit can analyze the data to determine a location of a milling target, a status of the milling operation, and undesirable milling conditions down hole. The control unit can perform a remedial action, such as by turning on a pump to remove debris from the wellbore.

Abstract: Present invention teaches a foldable truck rack that can be collapsed down when not in use, saving gas consumption and adding flexibility of space utilization of the bed portion of a pickup truck. One configuration allows the top horizontal bar to be lowered down with two upright bars sliding towards each other, until the top horizontal bar completely folded on top of the two upright bars, reducing the physical volume of the truck rack. A second configuration is made up of two half-bars to form a straight top horizontal bar, secured by a bracket with two lug nuts. When the two half-bars are folded down in a lateral axial direction to the corresponding upright bars, they are then pivoted down in a longitudinal direction towards base pieces, resulting in wide open space of a truck bed for more versatile use.

Abstract: Embodiments described herein relate to an apparatus that includes a thermal block with a gas inlet, and a gas line fluidly coupled to the gas inlet of the thermal block. In an embodiment, a base is coupled to the thermal block, where the base includes an embedded channel coupled to a fluid inlet. In an embodiment, an air gap is provided between at least a portion of the thermal block and a portion of the base.

Abstract: A modular robot is provided. The modular robot includes a sweeper module having a container for collecting debris from a surface of a location. The sweeper module is coupled to one or more brushes for contacting the surface and moving said debris into said container. Included is a robot module having wheels and configured to couple to the sweeper module. The robot module is enabled for autonomous movement and corresponding movement of the sweeper module over the surface. A controller is integrated with the robot module and interfacing with the sweeper module. The controller is configured to execute instructions for assigning of at least two zones at the location and assigning a work function to be performed using the sweeper module at each of the at least two zones. The controller is further configured for programming the robot module to activate the sweeper module in each of the two zones. The assigned work function is set for performance at each of the at least two zones.

Abstract: A method for mapping brain function of a subject includes receiving a dataset of resting state fMRI (RS-fMRI) three dimensional (3D) image frames of the subject's brain, and inputting the 3D image frames to a deep learning artificial neural network. For each voxel of each 3D image frame and for each resting state network of a plurality of resting state networks, the deep learning artificial neural network calculates a probability that the voxel belongs to the resting state network. The deep learning artificial neural network is trained beforehand using a plurality of 3D image frames including previously defined resting state networks obtained from a plurality of calibration subjects. The method includes generating one or more functional map of the plurality of resting state networks of the subject's brain using the probabilities calculated by the artificial neural network.

Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.

Abstract: The present invention relates to an insoluble support comprising distal binding sites, the support comprising a homogeneous polymeric matrix and constructs, the constructs covalently bound to the polymeric matrix, wherein the constructs comprise at least one branching agent selected from aminoalkanoic acids comprising at least 2 amino groups and from 3 up to 10 carbon atoms, cleavable linkers and at least one spacer coupled to at least one branching agent via an amide bond, the cleavable linkers providing the distal binding sites.

Abstract: A method may include receiving an indication of an electromechanical tool system including two or more tool components, where each tool component is configured to perform a respective service, retrieving electronic information for the two or more tool components based on the indication, retrieving firmware information for the two or more tool components based on the indication, generating a service definition file based on the electronic information and the firmware information, where the service definition file indicates a plurality of services capable of being performed by the two or more tool components, and outputting the service definition file to control operation of the electromechanical tool system.

Abstract: A Captioned Telephone Service (“CTS”) system, equipped with a CTS application, offers several user interfaces. These interfaces are designed to set the primary and secondary languages of the user, as well as the caption language of a contact. This configuration ensures that the caption language of a phone call matches the caption language assigned to the contact if the call is made with that contact. Additionally, if the caption language during a phone call is found to be incorrect, the system allows for a swift change to another language. This could be either the primary or secondary language of the user, or a completely different language, as required during the call.

Abstract: An automated annotation system to automatically designate annotations to records within a report, which may perform operations that include: designating an annotation to a location, the annotation comprising a text string; identifying a record of the location within a report; selecting the annotation based on the record of the location within the report; and applying the text string of the annotation to the record within the report, according to certain example embodiments.