Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: A machine including an adjustable cradle configured to hold, individually at different times, electronic devices having different dimensions. The machine also can include an alignment base configured to engage, individually at different times, with alignment mechanisms of overlay applicators, each respective one of the overlay applicators comprising a respective overlay configured to be applied to a respective surface of each of the electronic devices. The machine can be configured to facilitate applying, individually at different times, the respective overlays to the respective surfaces of the electronic devices. The adjustable cradle can include a fixed corner holder and an adjustable corner holder. The adjustable corner holder can be configured to hold each of the electronic devices between the adjustable corner holder and the fixed corner holder when each of the electronic devices is held within the adjustable cradle. Other embodiments are described.

Abstract: A hydraulic energy retention system includes a body with a piston separating a hydraulic fluid from a pressurized gas, a discharge port in fluid communication with the hydraulic fluid, and a stop operable to an engaged position to block movement of the piston past the stop and toward the discharge port. The hydraulic energy retention system may be implemented with a hydraulic fluid reservoir, such as a bootstrap reservoir.

Abstract: A contact includes a cantilever beam and a protection tab. The cantilever beam extends from a beam connected end to a beam free end along an insertion direction. The protection tab extends from a tab connected end to a tab free end in a direction opposite to the insertion direction. The tab free end is positioned adjacent to the beam free end.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: Systems and methods for distributed voice processing are disclosed herein. In one example, the method includes detecting sound via a microphone array of a first playback device and analyzing, via a first wake-word engine of the first playback device, the detected sound. The first playback device may transmit data associated with the detected sound to a second playback device over a local area network. A second wake-word engine of the second playback device may analyze the transmitted data associated with the detected sound. The method may further include identifying that the detected sound contains either a first wake word or a second wake word based on the analysis via the first and second wake-word engines, respectively. Based on the identification, sound data corresponding to the detected sound may be transmitted over a wide area network to a remote computing device associated with a particular voice assistant service.

Abstract: A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Abstract: The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: A method and system for quantifying a lack of parity for a subjective data set and an objective data set within an injury profile report. The method and system analyzes and inspects each subjective and objective data set and compares these data sets to a historical accuracy database to find a lack of agreement or non-parity of the data sets. The method and system quantifies the lack of parity, creates an injury profile report and proscribes any functional limitations for the injured worker. The output can be used to assign safer and more accurate functional limitations and assign safer and more accurate functional limitations to support a safer return to work event for the inured worker after injury.

Abstract: This disclosure describes methods, non-transitory computer-readable media, and systems that can (i) identify reads that align with at least some portion of alternative contiguous sequences representing structural variant haplotypes within a structural variant reference genome and (ii) generate a structural-variant-alignment tag within an alignment file for such read alignments to guide identifying candidate structural-variant locations. In addition to employing structural-variant-alignment tags, the disclosed systems identify read fragments that align or overlap with portions of alternate contiguous sequences representing an insertion (or other structural variant) and further masks such insertion-overlapping read fragments as part of an alignment file.

Abstract: A system for providing information to an occupant of a vehicle includes an automated driving system, a display configured to provide information to the occupant, and a controller in electrical communication with the automated driving system and the display. The controller is programmed to determine an automation confidence level for a location of interest using the automated driving system. The location of interest is a location in an environment surrounding the vehicle. The controller is further programmed to notify the occupant using the display based at least in part on the automation confidence level.

Abstract: A tubing assembly is provided that can comprise a plurality of tubes or lumens that can be disposed within a head of a peristaltic pump. The tubing assembly can provide a flow rate or volume capacity that is generally equal to or greater than that achieved with a comparable prior art tube while operating at higher pressures than that possible using the prior art tube. Further, in accordance with some embodiments, the tubing assembly can achieve a longer working life than a comparable prior art tube, and the load on the pump motor can be reduced such that the pump life is increased and/or a larger pump motor is not required to achieve such advantageous results.

Abstract: Packaging apparatus comprises two counter-rotatable sealing dies for pressing together two tissue webs to produce pockets for containing a substance for preparing beverages and to seal around said pockets, and two heating drums for heating the sealing dies and each being positioned inside a respective sealing die, wherein a first heating zone of each heating drum comprises a first plurality of circumferentially distributed infrared heating elements, and a second heating zone of each heating drum comprises a second plurality of circumferentially distributed infrared heating elements.

Abstract: A storage system performs garbage collection, with data compression, in storage memory. The system obtains hash results from data segments. The system determines similarity of content of data segments, based on the hash results. The system performs data compression of live data of two or more data segments that have similarity of content meeting a similarity threshold. The system writes the compressed live data of the two or more data segments into the storage memory.

Abstract: The absorbent article includes a topsheet having a body contacting surface, a backsheet joined to said topsheet, and an absorbent core disposed between the topsheet and the backsheet, wherein the absorbent core has a first absorbent core having a first area and a second area, wherein the first absorbent core and the second absorbent core are vertically arranged, wherein the second absorbent core at least partially covers the second area of the first absorbent core, and wherein the first absorbent core and the second absorbent core have different compositions.

Abstract: A method includes accessing a first dataset including aerial imagery data and infrared data, accessing a second dataset including property boundary data, and identifying property boundaries associated with a geographic area. A plurality of models is applied to the datasets to identify and compute information of interest. Based on the first dataset and constrained by the property boundaries, a building detection model can be applied to identify a building, and a vegetation detection model can be applied to identify one or more areas of vegetation. An estimated distance can be determined between each of the areas of vegetation and the building as separation data, which can be compared to a defensible space guideline to determine a defensible space adherence score. A wildfire risk map can be generated, including the defensible space adherence score associated with the geographic area.

Abstract: Techniques for determining and displaying error messages including a cause of an error generated because two types are not members of the same nest are disclosed. The system detects, at runtime, an instruction in a first type that attempts to access a private member of a second type. The system evaluates one or more nestmate criteria to determine whether the first type and the second type are within a same nest. A nest host corresponding to the nest specifies each nest member of the nest, and each nest member specifies an association with the nest. Responsive to determining that a particular nestmate criterion is not met, the system determines that the first type and the second type are not within the same nest and records or displays data identifying the particular nestmate criterion that has not been met, and throws an access error.

Abstract: In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

Abstract: A method includes receiving a first signal at a front-end module (FEM) comprising a power amplifier, the first signal indicating an increase in expected power or modulation, in response to receiving the first signal, increasing power at the power amplifier for one or more packets; and, after processing the one or more packets, reducing power at the power amplifier.