Patents by Inventor John Lee SPUDICH

John Lee SPUDICH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITONS AND METHODS FOR USE OF KALIUM CHANNEL RHODOPSINS
    Publication number: 20240101637
    Abstract: Methods and compositions used to identify and characterize novel rhodopsin domains, which are kalium (potassium)-conducting channelrhodopsins. The rhodopsin domain of these kalium (potassium)-conducting channelrhodopsins have been cloned, optimized and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
    Type: Application
    Filed: September 12, 2023
    Publication date: March 28, 2024
    Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, BAYLOR COLLEGE OF MEDICINE
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV, Mingshan XUE
  • Compositions and methods for use of anion channel rhodopsins
    Patent number: 10519205
    Abstract: Methods and compositions used to identify and characterize a new class of rhodopsins derived from algae, which are highly sensitive and efficient anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 31, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • COMPOSITIONS AND METHODS FOR USE OF ANION CHANNEL RHODOPSINS
    Publication number: 20190367564
    Abstract: Methods and compositions used to identify and characterize novel rhodopsin domains, which are anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned, optimized and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
    Type: Application
    Filed: November 17, 2017
    Publication date: December 5, 2019
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV, Michael MELKONIAN
  • HIGH-EFFICIENCY, SODIUM-SPECIFIC, BLUE-SHIFTED CHANNELRHODOPSINS
    Publication number: 20180305417
    Abstract: Methods and compositions used to identify and characterize a new channelrhodopsin derived from algae which is highly efficient, sodium specific and blue-shifted. The rhodopsin domain of this channelrhodopsin can be cloned and expressed in mammalian systems and thus used in optogenetic applications and as therapeutic agents.
    Type: Application
    Filed: July 6, 2018
    Publication date: October 25, 2018
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • COMPOSITIONS AND METHODS FOR USE OF ANION CHANNEL RHODOPSINS
    Publication number: 20180118793
    Abstract: Methods and compositions used to identify and characterize a new class of rhodopsins derived from algae, which are highly sensitive and efficient anion-conducting channelrhodopsins. The rhodopsin domain of these anion-conducting channelrhodopsins have been cloned and expressed in mammalian systems and thus may be used in, among others, optogenetic applications and as therapeutic agents for electrically active cell mediated disorders.
    Type: Application
    Filed: March 18, 2016
    Publication date: May 3, 2018
    Applicant: Board of Regents of the University of Texas System
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV
  • cDNA-derived nucleic acids encoding red-shifted channelrhodopsins
    Patent number: 9676836
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: June 13, 2017
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • HIGH-EFFICIENCY, SODIUM-SPECIFIC, BLUE-SHIFTED CHANNELRHODOPSINS
    Publication number: 20170073380
    Abstract: Methods and compositions used to identify and characterize a new channelrhodopsin derived from algae which is highly efficient, sodium specific and blue-shifted. The rhodopsin domain of this channelrhodopsin can be cloned and expressed in mammalian systems and thus used in optogenetic applications and as therapeutic agents.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 16, 2017
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV
  • cDNA-DERIVED NUCLEIC ACIDS ENCODING RED-SHIFTED CHANNELRHODOPSINS
    Publication number: 20150299291
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Application
    Filed: July 1, 2015
    Publication date: October 22, 2015
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV
  • HIGH-EFFICIENCY, SODIUM -SPECIFIC, BLUE-SHIFTED CHANNELRHODOPSINS
    Publication number: 20150232528
    Abstract: Methods and compositions used to identify and characterize a new channelrhodopsin derived from algae which is highly efficient, sodium specific and blue-shifted. The rhodopsin domain of this channelrhodopsin can be cloned and expressed in mammalian systems and thus used in optogenetic applications and as therapeutic agents.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 20, 2015
    Inventors: John Lee SPUDICH, Elena G. Govorunova, Oleg A. Sineshchekov
  • cDNA-derived nucleic acids encoding red-shifted channelrhodopsins
    Patent number: 9102747
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: August 11, 2015
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • cDNA-DERIVED NUCLEIC ACIDS ENCODING RED-SHIFTED CHANNELRHODOPSINS
    Publication number: 20140135382
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Application
    Filed: October 14, 2013
    Publication date: May 15, 2014
    Applicant: Board of Regents of the University of Texas System
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV
  • cDNA-derived nucleic acids encoding red-shifted channelrhodopsins
    Patent number: 8580937
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: November 12, 2013
    Assignee: Board of Regents of the University of Texas System
    Inventors: John Lee Spudich, Elena G. Govorunova, Oleg A. Sineshchekov
  • RED-SHIFTED CHANNELRHODOPSINS
    Publication number: 20130066047
    Abstract: Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted channelrhodopsins can be cloned and expressed in mammalian systems and used in optogenetic applications and as therapeutic agents. Also provided are methods and compositions for use in red-shifting the absorbance maxima of channelrhodopsins in order to improve their utility for use in vivo.
    Type: Application
    Filed: March 14, 2012
    Publication date: March 14, 2013
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John Lee SPUDICH, Elena G. GOVORUNOVA, Oleg A. SINESHCHEKOV