Abstract: The present disclosure relates to the field of medicine. More particularly, the disclosure is in the field of treatment of diabetes, obesity and/or chronic weight management, dyslipidemia and/or NASH. The disclosure relates to compounds that agonize the amylin receptor and can lower food intake, body weight, glucose and/or triglycerides, so can be used to treat diabetes, obesity, and/or dyslipidemia. The present disclosure also includes pharmaceutical compositions containing such compounds and therapeutic uses of such compounds and compositions.

Abstract: Disclosed herein are system, method, and computer program product embodiments for generating a list of deny policy statements associated with an allow policy statement with respect to the effective access permissions for a principal in an identity and access management system. The operations can include identifying a first policy statement that specifies members of a first identity set including the principal are allowed to access a first system resource set. The operations further include identifying a second policy statement specifying that members of a second identity set are denied access to a second system resource set. Moreover, the operations include determining that the second policy statement overlaps with the first policy statement with respect to the effective access permissions for the principal, and placing the second policy statement into the list of deny policy statements associated with an allow policy statement.

Abstract: A method, system, and apparatus for a live sporting event broadcast system. Embodiments include one or more video cameras that record the live sporting event; one or more sensors that track movement of one or more players in the live sporting event; one or more sensors that track location data of one or more pieces of equipment used in the live sporting event; at least one processor configured to: determine and/or track situational data of the live sporting event and synchronizes the tracked player movement and location data of the one or more pieces of equipment with the tracked situational data, compare the synchronized tracked player movement and the tracked location data of the one or more pieces of equipment with historical data, and determine at least an expected player movement in an upcoming action in the live event; a video highlight that is displayed on a broadcast transmission stream.

Abstract: An access token broker is executed within a first iFrame, a fully trusted application is executed in a second iFrame within the first iFrame, and a partially trusted application is executed in a third iFrame within the second iFrame. The partially trusted application may identify the iFrame in which the access token broker is executing and request an access token from the access token broker. The access token broker determines whether the request for the access token is to be granted. If the request is to be granted, the access token broker requests the access token from a hosting application. The hosting application obtains the requested access token from an access token server and provides the access token to the access token broker. The access token broker receives the access token from the hosting application and provides the access token to the partially trusted application.

Abstract: A method for graphically displaying data. The method can include sensing a position of a ball on a field using one or more sensors during a live sporting event; sensing human movement and location information using one or more sensors in the live sporting event; determining positioning information of one or more players based on the sensed human movement and location information and the sensed ball position on the field; and generating graphical indica on a transmitted broadcast of the live sporting event, the graphical indica showing a generated graphic of at least one of positioning information and ball position on the field.

Abstract: A method of time of flight (ToF) mass spectrometry comprising: pushing ions into a ToF mass analyser in a plurality of pushes, wherein the time spacing between adjacent pushes is shorter than either the longest flight time, or the range of flight times, of the ions; detecting the ions so as to obtain spectral data; decoding the spectral data to determine first mass spectral data relating to ions pushed into the ToF mass analyser by a first plurality of the pushes (P1-P4), and allocating this first mass spectral data to a first time stamp (t1); and decoding the spectral data to determine second mass spectral data relating to ions pushed into the ToF mass analyser by a second plurality of the pushes (P5-P8), and allocating this second mass spectral data to a second time-stamp (t2); wherein the first and second time-stamps have a time difference therebetween that is shorter than said longest flight time, or said range of flight times (4), in the ToF mass analyser.

Abstract: Some embodiments of the invention provide a forwarding element (e.g., a switch, a router, etc.) that has one or more data plane, message-processing pipelines with key-value processing circuits. The forwarding element's data plane key-value circuits allow the forwarding element to perform key-value services that would otherwise have to be performed by data compute nodes connected by the network fabric that includes the forwarding element. In some embodiments, the key-value (KV) services of the forwarding element and other similar forwarding elements supplement the key-value services of a distributed set of key-value servers by caching a subset of the most commonly used key-value pairs in the forwarding elements that connect the set of key-value servers with their client applications.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

Abstract: The disclosure generally relates to ultra high molecular weight poly (ethylene) (“UHMWPE”) tubes with an average wall thickness of 0.2 mm or less; a tensile stress at break greater than 40 MPa; and a storage modulus of greater than 500 MPa at 23° C. The disclosure further relates to preparing and using such tubes and to constructions (e.g., catheter constructions) and components thereof including such tubes.

Abstract: A method, system and apparatus for sensing data and updating statistical data. The method, system and apparatus can include one or more sensors physically located at a live sporting event that collect sensed data; a live database that receives sensor data continuously during activity in the live sporting event; a base module that continuously polls the live database, stores sensed data from any completed action in the live event in a sensed data database, and transmits the sensed data to a historical action database; a situational database that houses situational data about sensed data; and a processor that associates the situational data is with the sensed data to determine dynamic statistical data.

Abstract: A method, system, and apparatus for tracking actions in a live event. Embodiments can include one or more cameras located at the live event, the one or more cameras each focused on at least one of a player participating in the live event or equipment used in the live event, and one or more cameras collect sensed movement data regarding the at least one player or the equipment; and a processor that receives transmitted sensed movement data, compares the sensed movement data to historical movement data in a database, and determines a predicted movement of the at least one player or equipment in the live event. Further, the historical movement data in the database is updated in substantially real time after the collection of the sensed movement data by the one or more cameras.

Abstract: Methods, systems, and devices for PFAS destruction including providing water containing PFAS to a reactor vessel, irradiating the water with UV light under conditions to destroy at least a portion of the PFAS, passing the treated water through a selective membrane to form permeate and membrane reject comprising PFAS, providing the membrane reject back to the reactor vessel, providing additional water containing PFAS to the reactor vessel within the reactor vessel or before being provided to the reactor vessel, and irradiating the membrane reject and the additional water containing PFAS within the reactor vessel with UV light. The steps may be repeated a plurality of times such that PFAS that is not destroyed is recycled through the reactor vessel. Sensitizers may be added and may also be recycled in the membrane reject with the PFAS.

Abstract: Embodiments are directed to a series of novel small molecule activators of NRF2 dependent gene expression that are evaluated in an effort to develop therapeutic methods against diseases with deregulated KEAP1-NRF2 signaling.

Abstract: A method for cooling a product with a refrigeration system is provided. The method includes providing a product within a storage chamber defined by an opening wall surface, a floor surface, a rear wall surface and a ceiling wall surface. The ceiling wall is cooled with cooled air in contact with an opposing surface of an internal baffle. The ceiling wall surface is maintained at a temperature to provide convective heat absorption from the ceiling wall surface in the storage chamber. An enveloping airflow of the cooled air is induced downward along the opening wall surface by discharging the cooled air from the discharge chamber into a discharge area within the storage chamber adjacent the opening wall.

Abstract: The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Abstract: The absorbent article includes a topsheet having a body contacting surface, a backsheet joined to said topsheet, and an absorbent core disposed between the topsheet and the backsheet, wherein the absorbent core has a first absorbent core having a first area and a second area, wherein the first absorbent core and the second absorbent core are vertically arranged, wherein the second absorbent core at least partially covers the second area of the first absorbent core, and wherein the first absorbent core and the second absorbent core have different compositions.

Abstract: A system and method for animating an avatar in a virtual world comprising an image processor arranged to process a stream of images capturing an active user to obtain an activity data set arranged to track the activity of the user; an avatar spatial processor arranged to process the activity data set to determine a plurality of motion tracking points arranged to track the user's activity over a three-dimensional space; a facial expression detection engine arranged to process the activity data set to detect one or more facial expressions of the user; and, an avatar animation engine arranged to animate the avatar in the virtual world with the plurality of motion tracking points and the detected one or more facial expressions so as to mirror the actions and facial expressions of the active user.

Abstract: In some implementations, a controller for a hybrid powertrain system may cause disengagement of an engine from an electric machine via a clutch based on a state of charge (SOC) of one or more batteries connected to the electric machine at least meeting an SOC threshold. Disengagement of the engine may cause the hybrid powertrain system to operate in an electric-only mode for powering a load. The controller may detect a power event that includes at least one of a level of demand of the load exceeding a demand threshold, or the SOC of the one or more batteries being below the SOC threshold. The controller may cause, based on detection of the power event, engagement of the engine with the electric machine via the clutch. Engagement of the engine may enable the hybrid powertrain system to operate in a hybrid mode for powering the load.

Abstract: A bracket for suspending multiple line segments at an elevated location is disclosed. The bracket has a back portion to engage against a supporting surface at the elevated location. The back portion has a left segment and a right segment. The bracket has at least one of a left arm extending from the left segment or a right arm extending from the right segment. The bracket has at least one of a first left seat extending from the left arm, a second left seat extending from the left arm, a first right seat extending from the right arm, or a second right seat extending from the right arm. At least one of the multiple line segments are supported by at least one of the first left seat, the second left seat, the first right seat, or the second right seat.