Patents by Inventor John Leet

John Leet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of HCV replication
    Publication number: 20060276511
    Abstract: Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
    Type: Application
    Filed: June 5, 2006
    Publication date: December 7, 2006
    Inventors: Michael Serrano-Wu, Makonen Belema, Lawrence Snyder, Nicholas Meanwell, Denis St. Laurent, Ramesh Kakarla, Van Nguyen, Yuping Qiu, Xuejie Yang, John Leet, Min Gao, Donald O'Boyle, Julie Lemm, Fukang Yang
  • Nocathiacin antibiotics prepared by biotransformation or chemical methods
    Publication number: 20020055465
    Abstract: Novel nocathiacin derivatives have been prepared by both biotransformation and chemical methods. A novel nocathiacin derivative, nocathiacin IV, was prepared by either incubation of protease from Streptomyces griseus (Sigma, Cat# P5147) with nocathiacin I in DMF or by chemical methods. Fermentation of Actinoplanes sp. ATCC 53771 in the presence of nocathiacin IV produces a new compound nocathiacin IV 6-deoxyglucoside. Both nocathiacin IV and nocathiacin IV 6-deoxyglucoside have broad spectrum antibiotic activity against Gram-positive bacteria and have in vivo efficacy in animals.
    Type: Application
    Filed: July 31, 2001
    Publication date: May 9, 2002
    Inventors: Wenying Li, John Leet, Xiaohua Huang, Kin Sing Lam, Alicia Regueiro-Ren