Patents by Inventor John Leheup Archibald

John Leheup Archibald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4076820
    Abstract: The invention relates to novel benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 represents hydrogen, lower alkyl or aryl and R.sup.4 represents --SO.sub.2 R.sup.5 (where R.sup.5 is lower alkyl or aryl, --CONH.sub.2 or --CXNHR.sup.6 (where X is oxygen or sulphur and R.sup.6 is aryl or aryl.CO.--). The compounds have hypotensive activity.
    Type: Grant
    Filed: May 13, 1976
    Date of Patent: February 28, 1978
    Assignee: John Wyeth & Brother, Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Patent number: 4061758
    Abstract: A group of heterocyclic compounds generally exhibiting central nervous system activity (such as depressant and anti-convulsant activities) and, in some cases, cardiovascular and/or anti-inflammatory activity are described. The compounds have the formula ##STR1## where A is an ethyl or propyl group which is monosubstituted by defined substituents or a di(loweralkyl) amino (loweralkoxy) carbonyl group and R is a phenyl group which may be substituted by defined substituents. Pharmaceutical compositions having hypotensive activity or central nervous system activity comprise a non-toxic carrier and an effective amount of such a compound.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: December 6, 1977
    Assignee: John Wyeth & Brother Limited
    Inventor: John Leheup Archibald
  • Patent number: 4061640
    Abstract: Compounds of the formula ##STR1## in which W is quinolyl or lower alkyl quinolyl;A is alkylene of 1 to 6 carbon atoms;R is phenyl, halophenyl, lower alkoxy phenyl or lower alkyl phenyl;Or a pharmaceutically acceptable acid addition salt thereof, are hypotensive and bradycardial agents.
    Type: Grant
    Filed: July 29, 1976
    Date of Patent: December 6, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4061641
    Abstract: The invention provides compounds of general formula I ##STR1## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents hydrogen or lower alkyl, R.sup.3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R.sup.4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur.The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.
    Type: Grant
    Filed: July 15, 1976
    Date of Patent: December 6, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Patent number: 4046767
    Abstract: Novel piperidine compounds and their use in treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds are piperidine compounds linked by the nitrogen atom to cycloalkyl or a substituted or unsubstituted phenyl radical through the intermediary of a lower-alkylene radical. The piperidine ring is further substituted by an acylamino residue.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: September 6, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4045444
    Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds are piperidine compounds linked by the nitrogen atom to a methylenedioxyphenyl or an ethylenedioxyphenyl radical through the intermediary of a group selected from a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical or a bivalent radical of the formula ##STR1## or --O--(lower alkylene). The piperidine rings are further substituted by a benzamido residue.
    Type: Grant
    Filed: April 20, 1976
    Date of Patent: August 30, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4045566
    Abstract: This invention relates to compounds having the general formula: ##STR1## wherein W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy; A represents a lower alkylene radical an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, or a cycloalkyl radical of 5 to 7 carbon atoms; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: August 30, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Patent number: 4038401
    Abstract: The invention provides 4-benzamido-1-[4-(indol-3-yl)-4-oxobutyl] piperidine and the pharmaceutically acceptable acid addition salts thereof. The compound and its salts exhibit hypotensive and anti-hypertensive activity.
    Type: Grant
    Filed: February 11, 1976
    Date of Patent: July 26, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Patent number: 4034098
    Abstract: This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.
    Type: Grant
    Filed: November 24, 1975
    Date of Patent: July 5, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Patent number: 4029801
    Abstract: Pharmaceutical compositions containing a group of heterocyclic compounds and their use in treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds used in the composition and/or methods are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted cycloalkyl, aryl or heterocyclic radical through the intermediary of a group selected from a lower-alkylene radical, a monoketo lower-alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula --NH.CO.(CH.sub.2).sub.n -- where n is 1, 2 or 3, ##STR1## or --0-(lower-alkylene)--. The piperidine ring is further substituted by an acylamino residue.
    Type: Grant
    Filed: April 2, 1975
    Date of Patent: June 14, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4028352
    Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds are piperidine compounds linked by the nitrogen atom to a halogen-substituted or unsubstituted phenyl radical through the intermediary of a ##STR1## GROUP WHEREIN N IS AN INTEGER FROM 1 TO 4, AND Ar represents phenyl or halophenyl. The piperidine rings are further substituted by a benzamido residue.
    Type: Grant
    Filed: April 20, 1976
    Date of Patent: June 7, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4028365
    Abstract: A group of benz[g]indolyl compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted benz[g]indolyl radical through the intermediary of a lower-alkylene radical. The piperidine rings are further substituted by an acylamino residue.
    Type: Grant
    Filed: November 15, 1974
    Date of Patent: June 7, 1977
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 4024147
    Abstract: A group of heterocyclic compounds generally exhibiting central nervous system activity (such as depressant and anti-convulsant activities) and, in some cases, cardiovascular and/or anti-inflammatory activity are described. The compounds have the formula ##STR1## where A is an ethyl or propyl group which is mono-substituted by defined substituents or a di(loweralkyl)amino (loweralkoxy) carbonyl group and R is a phenyl group which may be substituted by defined substituents.
    Type: Grant
    Filed: April 18, 1975
    Date of Patent: May 17, 1977
    Assignee: John Wyeth & Brother Limited
    Inventor: John Leheup Archibald
  • Patent number: 3992389
    Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted phenyl radical through the intermediary of a group selected from a lower-alkylene radical, a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula ##EQU1## or --O--(lower-alkylene)-. The piperidine rings are further substituted by a benzamido, substituted benzamido or cyclohexylcarboxamido residue.
    Type: Grant
    Filed: April 2, 1975
    Date of Patent: November 16, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Frederick Cavalla, John Leheup Archibald
  • Patent number: 3992544
    Abstract: Certain novel 4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c] pyridine derivatives and their pharmacologically acceptable salts are described. These compounds provide potent and non-toxic compositions for the treatment of hypertension. Certain of the disclosed compounds also display activity as anti-tremor agents.
    Type: Grant
    Filed: April 15, 1975
    Date of Patent: November 16, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, Kenneth Heatherington
  • Patent number: 3971787
    Abstract: 3-(7-Halo-4-quinolyl)-N-[di(loweralkyl)amino(lower alkyl)]-N-(lower alkyl)benzamides and 4-(7-halo-4-quinolyl)-N-[di(lower alkyl)amino(loweralkyl)]-N-(lower alkyl)benzamides and their pharmaceutically acceptable acid addition salts exhibit interesting anti-inflammatory activity. They also exhibit anti-malarial activity and anti-hypertensive activity.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: July 27, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Arnott Boyle, John Christopher Saunders
  • Patent number: 3971789
    Abstract: The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1##And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula--R.sub.3 N--A--NR.sub.1 R.sub.2 (II), ##SPC2##where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-malarial activity and, in some cases, show one or more of the following activities:- anti-inflammatory activity, anti-hypertensive activity, anti-trichomonal activity, inhibition of blood platelet aggregation, anti-ulcer activity and activity against allergic asthma.
    Type: Grant
    Filed: January 23, 1975
    Date of Patent: July 27, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Terence Arnott Boyle, John Christopher Saunders
  • Patent number: 3969528
    Abstract: The invention relates to bases of the formula ##SPC1##And their acid addition salts with pharmaceutically acceptable acids. In the formula R.sup.1 represents phenyl or phenyl substituted by one or more hydroxyl, lower alkyl lower alkoxy, trifluoromethyl or halogen groups. The compounds have hypoglycemic activity.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: July 13, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, Alan Chapman White, Robin Michael Black
  • Patent number: 3962258
    Abstract: The invention provides indolo[2,3-a]quinolizine derivatives which are active as hypotensive and anti-histamine agents. The invention also provides a pharmaceutical composition comprising an indolo[2,3-a]quinolizine derivative together with a pharmaceutical carrier.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: June 8, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Lambert Jackson, Brian John Bushell
  • Patent number: 3933829
    Abstract: The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1##And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula--R.sub.3 N--A--NR.sub.1 R.sub.2 (II)--nr.sub.1 n--r.sub.3 (iii a)Or--N N NR.sub.1 R.sub.2 (III b)where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-hypertensive activity and, in some cases, show one or more of the following activities: anti-malarial activity, anti-inflammatory activity, anti-trichomonal activity and inhibition of blood platelet aggregation.
    Type: Grant
    Filed: August 22, 1974
    Date of Patent: January 20, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: John Leheup Archibald, John Terence Arnott Boyle, John Christopher Saunders