Patents by Inventor John Leheup Archibald
John Leheup Archibald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4076820Abstract: The invention relates to novel benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 represents hydrogen, lower alkyl or aryl and R.sup.4 represents --SO.sub.2 R.sup.5 (where R.sup.5 is lower alkyl or aryl, --CONH.sub.2 or --CXNHR.sup.6 (where X is oxygen or sulphur and R.sup.6 is aryl or aryl.CO.--). The compounds have hypotensive activity.Type: GrantFiled: May 13, 1976Date of Patent: February 28, 1978Assignee: John Wyeth & Brother, LimitedInventors: John Leheup Archibald, John Lambert Jackson
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Patent number: 4061641Abstract: The invention provides compounds of general formula I ##STR1## and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 represents hydrogen or lower alkyl, R.sup.3 represents hydrogen, halogen, lower alkoxy, hydroxy, or lower alkyl, R.sup.4 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, thienyl, furyl, phenyl; phenyl mono- or disubstituted by halogen, lower alkyl, lower alkoxy, hydroxy or trifluoromethyl; or benzoyl, halobenzoyl, lower alkanoyl, cycloalkanoyl of 6 to 8 carbon atoms, or thienoyl, A represents an alkylene, mono- or diketo- or hydroxy-alkylene radical having from 1 to 5 carbon atoms and X is oxygen or sulphur.The compounds exhibit action on the cardiovascular system particularly hypotensive and/or anti-hypertensive activity.Type: GrantFiled: July 15, 1976Date of Patent: December 6, 1977Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Lambert Jackson
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Patent number: 4061640Abstract: Compounds of the formula ##STR1## in which W is quinolyl or lower alkyl quinolyl;A is alkylene of 1 to 6 carbon atoms;R is phenyl, halophenyl, lower alkoxy phenyl or lower alkyl phenyl;Or a pharmaceutically acceptable acid addition salt thereof, are hypotensive and bradycardial agents.Type: GrantFiled: July 29, 1976Date of Patent: December 6, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4061758Abstract: A group of heterocyclic compounds generally exhibiting central nervous system activity (such as depressant and anti-convulsant activities) and, in some cases, cardiovascular and/or anti-inflammatory activity are described. The compounds have the formula ##STR1## where A is an ethyl or propyl group which is monosubstituted by defined substituents or a di(loweralkyl) amino (loweralkoxy) carbonyl group and R is a phenyl group which may be substituted by defined substituents. Pharmaceutical compositions having hypotensive activity or central nervous system activity comprise a non-toxic carrier and an effective amount of such a compound.Type: GrantFiled: February 24, 1977Date of Patent: December 6, 1977Assignee: John Wyeth & Brother LimitedInventor: John Leheup Archibald
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Patent number: 4046767Abstract: Novel piperidine compounds and their use in treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds are piperidine compounds linked by the nitrogen atom to cycloalkyl or a substituted or unsubstituted phenyl radical through the intermediary of a lower-alkylene radical. The piperidine ring is further substituted by an acylamino residue.Type: GrantFiled: June 16, 1976Date of Patent: September 6, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4045566Abstract: This invention relates to compounds having the general formula: ##STR1## wherein W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy; A represents a lower alkylene radical an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, or a cycloalkyl radical of 5 to 7 carbon atoms; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.Type: GrantFiled: April 14, 1976Date of Patent: August 30, 1977Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Lambert Jackson
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Patent number: 4045444Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds are piperidine compounds linked by the nitrogen atom to a methylenedioxyphenyl or an ethylenedioxyphenyl radical through the intermediary of a group selected from a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical or a bivalent radical of the formula ##STR1## or --O--(lower alkylene). The piperidine rings are further substituted by a benzamido residue.Type: GrantFiled: April 20, 1976Date of Patent: August 30, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4038401Abstract: The invention provides 4-benzamido-1-[4-(indol-3-yl)-4-oxobutyl] piperidine and the pharmaceutically acceptable acid addition salts thereof. The compound and its salts exhibit hypotensive and anti-hypertensive activity.Type: GrantFiled: February 11, 1976Date of Patent: July 26, 1977Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Lambert Jackson
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Patent number: 4034098Abstract: This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.Type: GrantFiled: November 24, 1975Date of Patent: July 5, 1977Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Lambert Jackson
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Patent number: 4029801Abstract: Pharmaceutical compositions containing a group of heterocyclic compounds and their use in treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds used in the composition and/or methods are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted cycloalkyl, aryl or heterocyclic radical through the intermediary of a group selected from a lower-alkylene radical, a monoketo lower-alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula --NH.CO.(CH.sub.2).sub.n -- where n is 1, 2 or 3, ##STR1## or --0-(lower-alkylene)--. The piperidine ring is further substituted by an acylamino residue.Type: GrantFiled: April 2, 1975Date of Patent: June 14, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4028352Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds are piperidine compounds linked by the nitrogen atom to a halogen-substituted or unsubstituted phenyl radical through the intermediary of a ##STR1## GROUP WHEREIN N IS AN INTEGER FROM 1 TO 4, AND Ar represents phenyl or halophenyl. The piperidine rings are further substituted by a benzamido residue.Type: GrantFiled: April 20, 1976Date of Patent: June 7, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4028365Abstract: A group of benz[g]indolyl compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted benz[g]indolyl radical through the intermediary of a lower-alkylene radical. The piperidine rings are further substituted by an acylamino residue.Type: GrantFiled: November 15, 1974Date of Patent: June 7, 1977Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 4024147Abstract: A group of heterocyclic compounds generally exhibiting central nervous system activity (such as depressant and anti-convulsant activities) and, in some cases, cardiovascular and/or anti-inflammatory activity are described. The compounds have the formula ##STR1## where A is an ethyl or propyl group which is mono-substituted by defined substituents or a di(loweralkyl)amino (loweralkoxy) carbonyl group and R is a phenyl group which may be substituted by defined substituents.Type: GrantFiled: April 18, 1975Date of Patent: May 17, 1977Assignee: John Wyeth & Brother LimitedInventor: John Leheup Archibald
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Patent number: 3992544Abstract: Certain novel 4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c] pyridine derivatives and their pharmacologically acceptable salts are described. These compounds provide potent and non-toxic compositions for the treatment of hypertension. Certain of the disclosed compounds also display activity as anti-tremor agents.Type: GrantFiled: April 15, 1975Date of Patent: November 16, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, Kenneth Heatherington
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Patent number: 3992389Abstract: A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These compounds are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted phenyl radical through the intermediary of a group selected from a lower-alkylene radical, a mono-keto lower alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula ##EQU1## or --O--(lower-alkylene)-. The piperidine rings are further substituted by a benzamido, substituted benzamido or cyclohexylcarboxamido residue.Type: GrantFiled: April 2, 1975Date of Patent: November 16, 1976Assignee: John Wyeth & Brother LimitedInventors: John Frederick Cavalla, John Leheup Archibald
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Patent number: 3971787Abstract: 3-(7-Halo-4-quinolyl)-N-[di(loweralkyl)amino(lower alkyl)]-N-(lower alkyl)benzamides and 4-(7-halo-4-quinolyl)-N-[di(lower alkyl)amino(loweralkyl)]-N-(lower alkyl)benzamides and their pharmaceutically acceptable acid addition salts exhibit interesting anti-inflammatory activity. They also exhibit anti-malarial activity and anti-hypertensive activity.Type: GrantFiled: January 23, 1975Date of Patent: July 27, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Arnott Boyle, John Christopher Saunders
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Patent number: 3971789Abstract: The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1##And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula--R.sub.3 N--A--NR.sub.1 R.sub.2 (II), ##SPC2##where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-malarial activity and, in some cases, show one or more of the following activities:- anti-inflammatory activity, anti-hypertensive activity, anti-trichomonal activity, inhibition of blood platelet aggregation, anti-ulcer activity and activity against allergic asthma.Type: GrantFiled: January 23, 1975Date of Patent: July 27, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Terence Arnott Boyle, John Christopher Saunders
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Patent number: 3969528Abstract: The invention relates to bases of the formula ##SPC1##And their acid addition salts with pharmaceutically acceptable acids. In the formula R.sup.1 represents phenyl or phenyl substituted by one or more hydroxyl, lower alkyl lower alkoxy, trifluoromethyl or halogen groups. The compounds have hypoglycemic activity.Type: GrantFiled: April 8, 1975Date of Patent: July 13, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, Alan Chapman White, Robin Michael Black
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Patent number: 3962258Abstract: The invention provides indolo[2,3-a]quinolizine derivatives which are active as hypotensive and anti-histamine agents. The invention also provides a pharmaceutical composition comprising an indolo[2,3-a]quinolizine derivative together with a pharmaceutical carrier.Type: GrantFiled: May 17, 1974Date of Patent: June 8, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Lambert Jackson, Brian John Bushell
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Patent number: 3933829Abstract: The disclosure describes new 4-aminoquinoline derivatives of general formula ##SPC1##And their acid addition salts, where X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula--R.sub.3 N--A--NR.sub.1 R.sub.2 (II)--nr.sub.1 n--r.sub.3 (iii a)Or--N N NR.sub.1 R.sub.2 (III b)where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-hypertensive activity and, in some cases, show one or more of the following activities: anti-malarial activity, anti-inflammatory activity, anti-trichomonal activity and inhibition of blood platelet aggregation.Type: GrantFiled: August 22, 1974Date of Patent: January 20, 1976Assignee: John Wyeth & Brother LimitedInventors: John Leheup Archibald, John Terence Arnott Boyle, John Christopher Saunders