Patents by Inventor John Leonard Jakubczak

John Leonard Jakubczak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7109029
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: September 19, 2006
    Assignee: Cell Genesys, Inc.
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20030104625
    Abstract: The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Cheng Cheng, Lori Clarke, Sheila Connelly, David Leonard Ennist, Suzanne Forry-Schaudies, Mario Gorziglia, Paul L. Hallenbeck, Carl M. Hay, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps, Seshidhar Reddy Police, Patricia Clare Ryan, David A. Stewart, Yuefeng Xie
  • Publication number: 20030104624
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20020137213
    Abstract: This invention relates to mutated adenoviral fiber proteins and adenovirus particles containing such proteins. It further relates to polynucleotides encoding the proteins and vectors containing polynucleotides. It also relates to methods for making and using the adenoviral particles. With the mutated fiber proteins, the adenovirus particles no longer bind to their natural cellular receptor. They can then be “retargeted” to a specific cell type through the addition of a ligand to the virus capsid, which causes the virus to bind to and infect such cell. Specific fiber mutations are listed, which ablate binding to the natural receptor. Adenovirus particles with certain fiber mutations were found to enhance gene transfer to and expression in liver as compared to viral particles with wild-type fiber.
    Type: Application
    Filed: May 30, 2001
    Publication date: September 26, 2002
    Inventors: Paul L. Hallenbeck, Neeraja Idamakanti, John Leonard Jakubczak, Michael Kaleko, Michele Lynette Rollence, Theodore Smith, Susan C. Stevenson, David A. Stewart