Abstract: Provided are methods for isolating T-cells with T cell receptors (TCRs) optimized for reactivity to specific peptides and decreased cross-reactivity to non-target peptides. Advantageously, TCRs of the invention can be optimized to target cancer antigens and peptides while having reducing reactivity to healthy cells. Methods of the invention utilize a novel combination of culturing conditions that increase T-cell activation and allow for validation of TCR activity. Culturing conditions of the invention further reduce culturing times generally needed to achieve expanded reactive T-cells. Because of the robust nature of the activation and validation conditions of the present invention, variants of identified TCRs can also be optimized and validated for their response to peptides, including cancer peptides.

Abstract: A method is provided comprising receiving, at a first node, transactional data associated with a consumer (wherein the first node comprises a processor and a tangible, non-transitory memory), receiving, at the first node, a credit approval request associated with the consumer, wherein the credit approval request is associated with a proposed transaction, determining, by the first node, whether the transactional data conforms with the proposed transaction, and at least one of approving and denying the credit approval request in response to the determination.

Abstract: Systems and methods for differentiated application of an Adaptive Coding and Modulation (ACM) to enhance link performance in satellite communication systems are disclosed. A system may include a processor and a memory storing instructions, which when executed by the processor, cause the processor to dynamically compute bandwidth capacity of a terminal from a plurality of terminals. Based on the computed bandwidth capacity of the terminal, the processor may automatically determine a ModCod to be applied for transmission to or from the terminal to optimize bit error rate (BER) performance. The to processor may determine the ModCod using an ACM technique. For the plurality of terminals, the processor may dynamically determine aggregate bandwidth availability and congestion within the ACM technique to optimize sharing of available bandwidth.

Abstract: A method for cleaning contacts on a substrate incorporates ion control to selectively remove oxides. The method includes exposing the substrate to ions of an inert gas, supplying a first RF frequency of a first bias power supply to a substrate support, supplying a second RF frequency of a second bias power supply to a substrate support, and adjusting a first power level of the first RF frequency and a second power level of the second RF frequency to selectively remove oxide from at least one contact on the substrate while inhibiting sputtering of polymer material wherein the oxide removal is selective over removal of polymer material surrounding the at least one contact.

Abstract: Methods and apparatus for processing a substrate area provided herein. For example, methods for enhancing surface hydrophilicity on a substrate comprise a) supplying, using a remote plasma source, water vapor plasma to a processing volume of a plasma processing chamber to treat a bonding surface of the substrate, b) supplying at least one of microwave power or RF power at a frequency from about 1 kHz to 10 GHz and a power from about 1 kW to 10 kW to the plasma processing chamber to maintain the water vapor plasma within the processing volume during operation, and c) continuing a) and b) until the bonding surface of the substrate has a hydrophilic contact angle of less than 10°.

Abstract: A system is described for associating a media file with an identifier. An identifier may be encoded as a physical and/or virtual label which may be affixed to a physical object and/or incorporated into an electronic document. When a request is received which comprises the identifier, a response in the form of a media file may be delivered. Access privileges associated with a request may be determined based on criteria such as elements of the label, membership in a group of labels, a target object type, geographic data and/or sensor data included in a request.

Abstract: A payment system for a transaction between a user and a merchant includes establishing user account and merchant accounts with an mCreds processing agent, loading consumer credit into a consumer account of a user computing device associated with a permanent identifier, identifying a desired transaction by the user on a computer server; accessing a merchant account, authenticating the user by comparing a provided user credential provided by the user with the user credential present in the database, authenticating the user computing device by comparing a provided user device identifier with the permanent user device identifier present in the database, and processing a debit to the user mCreds account and a credit to the merchant mobile credit account.

Abstract: An interface generator 6 generates a user interface for a mobile communication device 2 by providing, at step S2, a menu of functional components to a website owner 5 and receiving an indication of which of the functional components are selected for inclusion in the user interface from the website owner, at step S3. When the interface generator 6 receives a request for the user interface from the mobile communication device 2, at step S7, it delivers the user interface to the mobile communication device, at step S8, for display by the mobile communication device 2. The generated user interface includes the selected functional components and selection of a functional component included in the displayed user interface by a user of the mobile communication device 2 causes the mobile communication device 2 to carry out a task.

Abstract: Dynamic in-route reconfiguration in a satellite network includes receiving at least one of transmit power capability and demand requirements from one or more active satellite terminals of the satellite network, determining a resulting in-route configuration during operation of the satellite network based on the received at least one of transmit power capability and demand requirements, comparing the determined resulting in-route configuration to a current in-route configuration. When the determined resulting in-route configuration is different from the current in-route configuration, establishing the determined resulting in-route configuration as the current in-route configuration and storing the established current in-route configuration in a dynamic in-route reconfiguration manager, and transmitting the established current in-route configuration to the one or more active satellite terminals.

Abstract: Impermeable porous particles include a porous polymer core, and a polymeric shell having a shell thickness of at least 5 nm. The impermeable porous particles have a median diameter of between 3 ?m and 200 ?m, and any pores in the polymeric shell have a diameter of less than 2 nm.

Abstract: A method for preparing core/shell particles includes forming a suspension of ethylenically unsaturated monomer droplets containing one or more monomers and a porogen in an aqueous medium containing a first stabilizer and a polymerization initiator, wherein at least one of the monomers is a cross-linking monomer, and wherein the first stabilizer is an inorganic colloid. The method further includes polymerizing the one or more monomers to form core/shell particles having a core of a porous polymer and a polymeric shell having a shell thickness of at least 5 nm, wherein any pores in the polymeric shell have a diameter of less than 2 nm.

Abstract: A vehicle system includes a steering wheel configured to output an output based on an input from a user, and a controller configured to: determine a target orientation of front wheels of a vehicle based on vehicle environment information, determine whether an orientation of the front wheels of the vehicle based on the output from the steering wheel deviates from the target orientation, disengage the steering wheel from the front wheels in response to determination that the orientation of the front wheels deviates from the target orientation, adjust the orientation of the front wheels to the target orientation and provide a feedback in response to adjusting the orientation of the front wheels to the target orientation.

Abstract: A system includes a camera configured to capture image data of an environment, a monitoring system configured to generate a gaze sequences of a subject, and a computing device communicatively coupled to the camera and the monitoring system. The computing device is configured to receive the image data from the camera and the gaze sequences from the monitoring system, implement a machine learning model comprising a convolutional encoder-decoder neural network configured to process the image data and a side-channel configured to inject the gaze sequences into a decoder stage of the convolutional encoder-decoder neural network, generate, with the machine learning model, a gaze probability density heat map, and generate, with the machine learning model, an attended awareness heat map.

Abstract: A method of switching from a first gateway within a plurality of first gateways to a second gateway in a network includes precaching configuration information on the second gateway, that is within the first gateways, prior to switch-over to the second gateway. The first gateway from which the second gateway is being switched is identified. The second gateway is configured in accordance with the configuration of the first gateway based on the precached configuration information prior to the switch-over to the second gateway. Data traffic from data applications using the network is replicated and sent to the first gateway and the second gateway. Bandwidths allocated to terminals in the network are frozen in association with the switch-over to the second gateway. The bandwidths allocated to the terminals in the network are unfrozen based at least in part on an indication of completion of the switch-over to the second gateway.

Abstract: A computer-implemented method for providing agent assisted transcriptions of user utterances. A user utterance is received in response to a prompt provided to the user at a remote client device. An automatic transcription is generated from the utterance using a language model based upon an application or context, and presented to a human agent. The agent reviews the transcription and may replace at least a portion of the transcription with a corrected transcription. As the agent inputs the corrected transcription, accelerants are presented to the user comprising suggested texted to be inputted. The accelerants may be determined based upon an agent input, an application or context of the transcription, the portion of the transcription being replaced, or any combination thereof. In some cases, the user provides textual input, to which the agent transcribes an intent associated with the input with the aid of one or more accelerants.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: A method of determining that a subject electronic device 1021 . . . N is counterfeit. The method involves delivering the web page component to a subject device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determined that the subject device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A method of preventing a subject communication device 1021 . . . N from accessing a resource when it is determined to be counterfeit. The method involves delivering the web page component to a subject communication device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject communication device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determines that the subject communication device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: Finding care plan(s) matching desired aspects includes receiving a selection of a model care plan from a user; generating a feature hash vector representing the model care plan, resulting in a model feature hash vector; comparing feature hash vectors of existing care plans to the model feature hash vector to find care plan(s) best matching the desired aspect(s) of a user, resulting in best match(es); and providing one or more care plan recommendation(s) to the user based on the best match(es).