Patents by Inventor John Lifter

John Lifter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and use of sialylated glycoforms of soluble complement receptor 1 (CR1)
    Patent number: 6057131
    Abstract: Provided are methods of making preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms and therapeutic methods using them. The preparations are suitable for treatment of allograft or xenograft rejection, diseases involving inflammation or inappropriate complement activation, and thrombotic or shock state conditions. Preferred methods employ sCR1 glycoforms that are sialylated, have a pI of .ltoreq.5.1, or have a sialic acid: mannose molar ratio of .gtoreq.0.25.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Henry C. Marsh, Jr., Richard A. G. Smith, Chang-Jing Grace Yeh, John Lifter, Anne Mary Freeman, Michael L. Gosselin
  • Therapeutic methods employing sialylated glycoforms of soluble complement receptor 1 (SCR 1)
    Patent number: 5858969
    Abstract: Provided are therapeutic methods employing preparations of recombinant soluble Complement Receptor type 1 (sCR1) defined with respect to the distribution of sCR1 glycoforms. The methods are suitable for treatment of disease involving inflammation, inappropriate complement activation, and in thrombotic or shock state conditions. Preferred methods employ sCR1 glycoforms that are sialylated, have a pI of .ltoreq.5.1, or have a sialic acid:mannose molar ratio of .gtoreq.0.25.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 12, 1999
    Assignee: T Cell Sciences, Inc.
    Inventors: Henry C. Marsh, Jr., Richard A.G. Smith, Chang-Jing Grace Yeh, John Lifter, Anne Mary Freeman, Michael L. Gosselin
  • Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo
    Patent number: 5456909
    Abstract: The present invention relates to novel glycoforms and preparations of the soluble complement receptor type 1 (sCR1), and their uses in the therapy of complement mediated diseases and disorders involving inflammation and inappropriate complement activation and in thrombotic or shock state conditions. The invention provides novel glycoforms and methods for producing, detecting, enriching and purifying such glycoforms. The invention further provides methods of specifically producing a glycoform by recombinant or chemical means. Preferred embodiments of the invention include sialylated glycoforms and glycoforms with a pI.ltoreq.5.1 determined by chromatofocusing or with a sialic acid to mannose molar ratio of >0.25. The glycoforms may be formulated alone in therapeutic compositions or in combination with thrombolytic agents.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: October 10, 1995
    Assignees: T Cell Sciences, Inc., SmithKline Beecham p.l.c.
    Inventors: Henry C. Marsh, Jr., Richard A. G. Smith, Chang-Jing G. Yeh, John Lifter, Anne M. Freeman, Michael L. Gosselin
  • Protein purification
    Patent number: 5252216
    Abstract: This invention relates to the application of combination chromatography to the purification of complement receptor proteins.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: October 12, 1993
    Assignee: SmithKline Beecham Corporation
    Inventors: Gail Folena-Wasserman, John H. O'Grady, Thomas M. Smith, John Lifter